HIT-result

Type	Detail
Target ID	T51U51
Protein Name	Neurogenic locus notch homolog protein 2
Uniprot ID	Q04721
Protein Name Alias	Notch 2; hN2
Gene ID	4853
Gene Symbol	NOTCH2
Gene Alias	NA
TTD	T88656: Clinical Trial target
Pfam	PF12661 ; PF00066 ; PF07684 ; PF07645 ; PF00008 ; PF06816 ; PF12796 ; PF11936
GO	0005634:nucleus 0043235:receptor complex 0007275:multicellular organism development 0035264:multicellular organism growth 0038023:signaling receptor activity 0030513:positive regulation of BMP signaling pathway 0072015:glomerular visceral epithelial cell development 0003184:pulmonary valve morphogenesis 0007050:cell cycle arrest 0045967:negative regulation of growth rate 0005789:endoplasmic reticulum membrane 0030326:embryonic limb morphogenesis 0046849:bone remodeling 0007399:nervous system development 0001709:cell fate determination 0001947:heart looping 0006915:apoptotic process 0043011:myeloid dendritic cell differentiation 0010838:positive regulation of keratinocyte proliferation 1990705:cholangiocyte proliferation 0061314:Notch signaling involved in heart development 0000139:Golgi membrane 0019827:stem cell population maintenance 2001204:regulation of osteoclast development 0005509:calcium ion binding 0072574:hepatocyte proliferation 0072104:glomerular capillary formation 0035622:intrahepatic bile duct development 0005887:integral component of plasma membrane 0051059:NF-kappaB binding 0046579:positive regulation of Ras protein signal transduction 0005886:plasma membrane 0002011:morphogenesis of an epithelial sheet 0019899:enzyme binding 0001701:in utero embryonic development 0060413:atrial septum morphogenesis 0045672:positive regulation of osteoclast differentiation 0002315:marginal zone B cell differentiation 0010629:negative regulation of gene expression 0002437:inflammatory response to antigenic stimulus 0070374:positive regulation of ERK1 and ERK2 cascade 0016020:membrane 0006959:humoral immune response 0030097:hemopoiesis 0070986:left/right axis specification 0009986:cell surface 2000249:regulation of actin cytoskeleton reorganization 0061073:ciliary body morphogenesis 0043065:positive regulation of apoptotic process 0005576:extracellular region 0007219:Notch signaling pathway 0000122:negative regulation of transcription by RNA polymerase II 0005929:cilium 0060674:placenta blood vessel development 0072014:proximal tubule development 0006367:transcription initiation from RNA polymerase II promoter 0005654:nucleoplasm 0042060:wound healing 0042742:defense response to bacterium 0007411:axon guidance 0043066:negative regulation of apoptotic process 0009887:animal organ morphogenesis
PDB	5MWB ; 2OO4
Drugbank	NA
KEGG	hsa:4853

Go to browser

Name: Tretinoin

Go to browser

Name: Ap

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens