Target Description

Type Detail
Target ID T84D97
Protein Name Growth/differentiation factor 2
Uniprot ID Q9UK05
Protein Name Alias GDF-2;  Bone morphogenetic protein 9;  BMP-9
Gene ID 2658
Gene Symbol GDF2
Gene Alias BMP9
TTD T27611: Clinical Trial target
Pfam PF00688 ; PF00019
GO
0030509:BMP signaling pathway

0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0043537:negative regulation of blood vessel endothelial cell migration

0030513:positive regulation of BMP signaling pathway

0061036:positive regulation of cartilage development

0016525:negative regulation of angiogenesis

0008156:negative regulation of DNA replication

0001938:positive regulation of endothelial cell proliferation

0001503:ossification

0051216:cartilage development

0060389:pathway-restricted SMAD protein phosphorylation

0005615:extracellular space

0001937:negative regulation of endothelial cell proliferation

0008083:growth factor activity

0005125:cytokine activity

0001570:vasculogenesis

0032924:activin receptor signaling pathway

0048514:blood vessel morphogenesis

0071773:cellular response to BMP stimulus

0030308:negative regulation of cell growth

0001569:branching involved in blood vessel morphogenesis

0001649:osteoblast differentiation

2000279:negative regulation of DNA biosynthetic process

0060395:SMAD protein signal transduction

0006879:cellular iron ion homeostasis

0032757:positive regulation of interleukin-8 production

0045893:positive regulation of transcription, DNA-templated

0005576:extracellular region

0045766:positive regulation of angiogenesis

0010596:negative regulation of endothelial cell migration

0070062:extracellular exosome

0001525:angiogenesis

0045603:positive regulation of endothelial cell differentiation

0045944:positive regulation of transcription by RNA polymerase II

PDB 4YCI ; 5I05 ; 4MPL ; 5HZW ; 1ZKZ ; 4FAO ; 4YCG
Drugbank NA
KEGG hsa:2658

Related Compounds  (Total: 1)

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C0456
Name: Tretinoin


Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens