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Target Description
Type
Detail
Target ID
T84D97
Protein Name
Growth/differentiation factor 2
Uniprot ID
Q9UK05
Protein Name Alias
GDF-2; Bone morphogenetic protein 9; BMP-9
Gene ID
2658
Gene Symbol
GDF2
Gene Alias
BMP9
TTD
T27611: Clinical Trial target
Pfam
PF00688
;
PF00019
GO
0030509:BMP signaling pathway
0010862:positive regulation of pathway-restricted SMAD protein phosphorylation
0043537:negative regulation of blood vessel endothelial cell migration
0030513:positive regulation of BMP signaling pathway
0061036:positive regulation of cartilage development
0016525:negative regulation of angiogenesis
0008156:negative regulation of DNA replication
0001938:positive regulation of endothelial cell proliferation
0001503:ossification
0051216:cartilage development
0060389:pathway-restricted SMAD protein phosphorylation
0005615:extracellular space
0001937:negative regulation of endothelial cell proliferation
0008083:growth factor activity
0005125:cytokine activity
0001570:vasculogenesis
0032924:activin receptor signaling pathway
0048514:blood vessel morphogenesis
0071773:cellular response to BMP stimulus
0030308:negative regulation of cell growth
0001569:branching involved in blood vessel morphogenesis
0001649:osteoblast differentiation
2000279:negative regulation of DNA biosynthetic process
0060395:SMAD protein signal transduction
0006879:cellular iron ion homeostasis
0032757:positive regulation of interleukin-8 production
0045893:positive regulation of transcription, DNA-templated
0005576:extracellular region
0045766:positive regulation of angiogenesis
0010596:negative regulation of endothelial cell migration
0070062:extracellular exosome
0001525:angiogenesis
0045603:positive regulation of endothelial cell differentiation
0045944:positive regulation of transcription by RNA polymerase II
PDB
4YCI
;
5I05
;
4MPL
;
5HZW
;
1ZKZ
;
4FAO
;
4YCG
Drugbank
NA
KEGG
hsa:2658
Related Compounds (Total: 1)
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C0456
Name: Tretinoin
Related Herbs (Total: 2)
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Herb id
Chinese Pin Yin
Chinese Character
English Name
Latin Name
H0360
Ren Zhong Bai
人中白
Human urine sediment
Homo sapiens
H0847
Zi He Che
紫河车
Human placenta
Homo sapiens