HIT-result

Type	Detail
Target ID	T20OEM
Protein Name	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Uniprot ID	Q13526
Protein Name Alias	EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1
Gene ID	5300
Gene Symbol	PIN1
Gene Alias	NA
TTD	T16308: Clinical Trial target
Pfam	PF00639 ; PF00397
GO	0005634:nucleus 0035307:positive regulation of protein dephosphorylation 0016859:cis-trans isomerase activity 0043547:positive regulation of GTPase activity 0030182:neuron differentiation 0043524:negative regulation of neuron apoptotic process 0005829:cytosol 0051443:positive regulation of ubiquitin-protein transferase activity 0007088:regulation of mitotic nuclear division 0098978:glutamatergic synapse 0031434:mitogen-activated protein kinase kinase binding 0090263:positive regulation of canonical Wnt signaling pathway 0000413:protein peptidyl-prolyl isomerization 0010468:regulation of gene expression 0036064:ciliary basal body 0061051:positive regulation of cell growth involved in cardiac muscle cell development 0043525:positive regulation of neuron apoptotic process 0001666:response to hypoxia 1902430:negative regulation of amyloid-beta formation 0007049:cell cycle 0005737:cytoplasm 2000146:negative regulation of cell motility 0043005:neuron projection 1901796:regulation of signal transduction by p53 class mediator 1900180:regulation of protein localization to nucleus 0001934:positive regulation of protein phosphorylation 0032480:negative regulation of type I interferon production 0032465:regulation of cytokinesis 0050808:synapse organization 0030496:midbody 0032092:positive regulation of protein binding 0060393:regulation of pathway-restricted SMAD protein phosphorylation 0048156:tau protein binding 0050821:protein stabilization 0099524:postsynaptic cytosol 0042177:negative regulation of protein catabolic process 0030512:negative regulation of transforming growth factor beta receptor signaling pathway 0001932:regulation of protein phosphorylation 0003774:motor activity 0005739:mitochondrion 0003755:peptidyl-prolyl cis-trans isomerase activity 0032794:GTPase activating protein binding 0032091:negative regulation of protein binding 0050815:phosphoserine residue binding 0005654:nucleoplasm 0031647:regulation of protein stability 0016607:nuclear speck 0050816:phosphothreonine residue binding 0045944:positive regulation of transcription by RNA polymerase II 0070373:negative regulation of ERK1 and ERK2 cascade 0008013:beta-catenin binding 0051219:phosphoprotein binding
PDB	2XP4 ; 5B3Z ; 2XP9 ; 1NMV ; 2Q5A ; 2KBU ; 2KCF ; 1I6C ; 1NMW ; 3KAC ; 4GWV ; 4U85 ; 6VAJ ; 2ITK ; 2M8J ; 2XP7 ; 2ZR5 ; 6O33 ; 2M9E ; 3TDB ; 2ZQU ; 1I8H ; 4U86 ; 2F21 ; 2ZR4 ; 4QIB ; 5B3X ; 4TYO ; 5B3Y ; 2ZQV ; 2M9J ; 6SVE ; 2XP3 ; 6DUN ; 3IKD ; 3IKG ; 6SVH ; 3JYJ ; 2RUC ; 2ZQT ; 3WH0 ; 2XP5 ; 5VTI ; 3KAD ; 2RUQ ; 4GWT ; 3TC5 ; 4U84 ; 6O34 ; 2RUD ; 2M8I ; 2M9I ; 2XPA ; 5B3W ; 2ZR6 ; 1I8G ; 3KCE ; 3KAF ; 6SVC ; 3KAI ; 5UY9 ; 5BMY ; 2ZQS ; 4TNS ; 1ZCN ; 3ODK ; 3OOB ; 2XPB ; 3IK8 ; 1PIN ; 3I6C ; 2XP8 ; 5VTK ; 2N1O ; 2RUR ; 2M9F ; 1F8A ; 3KAG ; 5VTJ ; 3NTP ; 3KAH ; 3TCZ ; 5GPH ; 2LB3 ; 2XP6 ; 3KAB
Drugbank	DB06867 ; DB01766
KEGG	hsa:5300

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1221	Hua Xiang Shu Guo Xu	化香树果序	NA	Platycarya strobilacea
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1220	Hua Xiang Shu Guo	化香树果	NA	Platycarya strobilacea
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0562	Tou Gu Cao	透骨草	Tuberculate speranskia	Speranskia tuberculata
H0002	Hui Xiang	茴香	Fennel fruit	Foeniculum vulgare