HIT-result

Target Description

Type	Detail
Target ID	T46E53
Protein Name	Retinoic acid receptor alpha
Uniprot ID	P10276
Protein Name Alias	RAR-alpha; Nuclear receptor subfamily 1 group B member 1
Gene ID	5914
Gene Symbol	RARA
Gene Alias	NR1B1
TTD	T94085: Clinical Trial target
Pfam	PF00104 ; PF00105
GO	0051099:positive regulation of binding 0006367:transcription initiation from RNA polymerase II promoter 0005634:nucleus 0009755:hormone-mediated signaling pathway 0005829:cytosol 0032754:positive regulation of interleukin-5 production 0003700:DNA-binding transcription factor activity 0032991:protein-containing complex 0008270:zinc ion binding 0045892:negative regulation of transcription, DNA-templated 0032753:positive regulation of interleukin-4 production 1990837:sequence-specific double-stranded DNA binding 0032720:negative regulation of tumor necrosis factor production 0001972:retinoic acid binding 0071391:cellular response to estrogen stimulus 0005654:nucleoplasm 0030154:cell differentiation 0019899:enzyme binding 0004879:nuclear receptor activity 0045893:positive regulation of transcription, DNA-templated 0045944:positive regulation of transcription by RNA polymerase II 0032526:response to retinoic acid 0003682:chromatin binding 0051018:protein kinase A binding 0009986:cell surface 0006468:protein phosphorylation 0007165:signal transduction 0030851:granulocyte differentiation 0015629:actin cytoskeleton 0000122:negative regulation of transcription by RNA polymerase II 0032736:positive regulation of interleukin-13 production 0043422:protein kinase B binding 0045787:positive regulation of cell cycle 0005730:nucleolus 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0008134:transcription factor binding 0043277:apoptotic cell clearance 0045630:positive regulation of T-helper 2 cell differentiation 0044323:retinoic acid-responsive element binding 0005102:signaling receptor binding 0030853:negative regulation of granulocyte differentiation 0048384:retinoic acid receptor signaling pathway 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0019904:protein domain specific binding 0000785:chromatin 0008284:positive regulation of cell population proliferation 0032689:negative regulation of interferon-gamma production 0005737:cytoplasm 0051393:alpha-actinin binding 0031490:chromatin DNA binding
PDB	5K13 ; 3KMR ; 1DKF ; 1DSZ ; 6XWG ; 4DQM ; 3KMZ ; 3A9E
Drugbank	DB00926 ; DB00210 ; DB00523 ; DB05785 ; DB12808 ; DB00799 ; DB00755 ; DB00459 ; DB04942 ; DB00982
KEGG	hsa:5914

Type

Detail

Target ID

T46E53

Protein Name

Retinoic acid receptor alpha

Uniprot ID

P10276

Protein Name Alias

RAR-alpha; Nuclear receptor subfamily 1 group B member 1

Gene ID

5914

Gene Symbol

RARA

Gene Alias

NR1B1

TTD

T94085: Clinical Trial target

Pfam

PF00104 ; PF00105

0051099:positive regulation of binding

0006367:transcription initiation from RNA polymerase II promoter

0005634:nucleus

0009755:hormone-mediated signaling pathway

0005829:cytosol

0032754:positive regulation of interleukin-5 production

0003700:DNA-binding transcription factor activity

0032991:protein-containing complex

0008270:zinc ion binding

0045892:negative regulation of transcription, DNA-templated

0032753:positive regulation of interleukin-4 production

1990837:sequence-specific double-stranded DNA binding

0032720:negative regulation of tumor necrosis factor production

0001972:retinoic acid binding

0071391:cellular response to estrogen stimulus

0005654:nucleoplasm

0030154:cell differentiation

0019899:enzyme binding

0004879:nuclear receptor activity

0045893:positive regulation of transcription, DNA-templated

0045944:positive regulation of transcription by RNA polymerase II

0032526:response to retinoic acid

0003682:chromatin binding

0051018:protein kinase A binding

0009986:cell surface

0006468:protein phosphorylation

0007165:signal transduction

0030851:granulocyte differentiation

0015629:actin cytoskeleton

0000122:negative regulation of transcription by RNA polymerase II

0032736:positive regulation of interleukin-13 production

0043422:protein kinase B binding

0045787:positive regulation of cell cycle

0005730:nucleolus

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0008134:transcription factor binding

0043277:apoptotic cell clearance

0045630:positive regulation of T-helper 2 cell differentiation

0044323:retinoic acid-responsive element binding

0005102:signaling receptor binding

0030853:negative regulation of granulocyte differentiation

0048384:retinoic acid receptor signaling pathway

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0019904:protein domain specific binding

0000785:chromatin

0008284:positive regulation of cell population proliferation

0032689:negative regulation of interferon-gamma production

0005737:cytoplasm

0051393:alpha-actinin binding

0031490:chromatin DNA binding

PDB

5K13 ; 3KMR ; 1DKF ; 1DSZ ; 6XWG ; 4DQM ; 3KMZ ; 3A9E

Drugbank

DB00926 ; DB00210 ; DB00523 ; DB05785 ; DB12808 ; DB00799 ; DB00755 ; DB00459 ; DB04942 ; DB00982

KEGG

hsa:5914

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Name: Tretinoin

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Name: Β-Cryptoxanthin

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Name: Abietic Acid

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Name: Alitretinoin

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Name: lutein

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H1049	Feng Xiang Zhi Chou Gao	枫香脂稠膏	NA	Liquidambar formosana
H0506	Song Xiang	松香	Colophony	Pinus massoniana
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0207	Ma Wei Song Shu Gen	马尾松树根	NA	Pinus massoniana
H0206	Ma Wei Song Gen	马尾松根	NA	Pinus massoniana
H0012	Ji Mu Ye Jin Gao	继木叶浸膏	NA	Loropetalum chinense
H1047	Feng Xiang Ye	枫香叶	NA	Liquidambar formosana
H0507	Song Zhi	松脂	Rosin	Pinus massoniana
H0177	Lu Lu Tong	路路通	Beautiful sweetgum	Liquidambar formosana

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 14)