HIT-result

Type	Detail
Target ID	T80LLJ
Protein Name	Prohibitin
Uniprot ID	P35232
Protein Name Alias	NA
Gene ID	5245
Gene Symbol	PHB
Gene Alias	PHB1
TTD	T02446: Research target
Pfam	PF01145
GO	0098982:GABA-ergic synapse 0002639:positive regulation of immunoglobulin production 0005634:nucleus 0070062:extracellular exosome 0042981:regulation of apoptotic process 0007202:activation of phospholipase C activity 0044830:modulation by host of viral RNA genome replication 0043434:response to peptide hormone 0045745:positive regulation of G protein-coupled receptor signaling pathway 0071897:DNA biosynthetic process 0035632:mitochondrial prohibitin complex 1901224:positive regulation of NIK/NF-kappaB signaling 0006355:regulation of transcription, DNA-templated 0030061:mitochondrial crista 0006851:mitochondrial calcium ion transmembrane transport 0140374:antiviral innate immune response 0098978:glutamatergic synapse 0023035:CD40 signaling pathway 0001552:ovarian follicle atresia 0098891:extrinsic component of presynaptic active zone membrane 0039529:RIG-I signaling pathway 0051897:positive regulation of protein kinase B signaling 0071354:cellular response to interleukin-6 0008285:negative regulation of cell population proliferation 0045892:negative regulation of transcription, DNA-templated 0014069:postsynaptic density 0010942:positive regulation of cell death 1990051:activation of protein kinase C activity 0005737:cytoplasm 0001851:complement component C3b binding 2000323:negative regulation of glucocorticoid receptor signaling pathway 0005887:integral component of plasma membrane 0060766:negative regulation of androgen receptor signaling pathway 0003714:transcription corepressor activity 0010628:positive regulation of gene expression 0001850:complement component C3a binding 0005886:plasma membrane 0019899:enzyme binding 0032740:positive regulation of interleukin-17 production 0048661:positive regulation of smooth muscle cell proliferation 0030308:negative regulation of cell growth 0042493:response to drug 0050821:protein stabilization 0042177:negative regulation of protein catabolic process 0001649:osteoblast differentiation 0045917:positive regulation of complement activation 0016020:membrane 0070373:negative regulation of ERK1 and ERK2 cascade 0070374:positive regulation of ERK1 and ERK2 cascade 0046718:viral entry into host cell 0009986:cell surface 0031100:animal organ regeneration 0016575:histone deacetylation 0045893:positive regulation of transcription, DNA-templated 0001541:ovarian follicle development 0035902:response to immobilization stress 0005769:early endosome 0000122:negative regulation of transcription by RNA polymerase II 0072538:T-helper 17 type immune response 0005739:mitochondrion 0045471:response to ethanol 0007165:signal transduction 0008022:protein C-terminus binding 0005743:mitochondrial inner membrane 0046982:protein heterodimerization activity 0005654:nucleoplasm 0010944:negative regulation of transcription by competitive promoter binding 0050847:progesterone receptor signaling pathway 0031871:proteinase activated receptor binding 0007005:mitochondrion organization 0042826:histone deacetylase binding 0031315:extrinsic component of mitochondrial outer membrane 0043066:negative regulation of apoptotic process 0042113:B cell activation
PDB	1LU7
Drugbank	DB15496 ; DB15495
KEGG	hsa:5245

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Name: Rocaglamide

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Name: Tretinoin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0245	Mi Lan Hua	米兰花	NA	Aglaia odorata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens