Target Description
| Type | Detail |
|---|---|
| Target ID | T10CQU |
| Protein Name | NEDD8-activating enzyme E1 regulatory subunit |
| Uniprot ID |
Q13564 |
| Protein Name Alias | Amyloid beta precursor protein-binding protein 1, 59 kDa; APP-BP1; Amyloid protein-binding protein 1; Proto-oncogene protein 1 |
| Gene ID |
8883 |
| Gene Symbol | NAE1 |
| Gene Alias | APPBP1 |
| TTD | T01447: Clinical Trial target |
| Pfam | PF00899 |
| GO |
0005737:cytoplasm
0045116:protein neddylation 0007165:signal transduction 0046982:protein heterodimerization activity 0042981:regulation of apoptotic process 0043687:post-translational protein modification 0043523:regulation of neuron apoptotic process 0032446:protein modification by small protein conjugation 0005829:cytosol 0032991:protein-containing complex 0033314:mitotic DNA replication checkpoint 0031625:ubiquitin protein ligase binding 0051402:neuron apoptotic process 0019781:NEDD8 activating enzyme activity 0005886:plasma membrane |
| PDB | 3GZN ; 1R4M ; 3DBR ; 1YOV ; 1TT5 ; 3DBL ; 1R4N ; 2NVU ; 3DBH |
| Drugbank | DB00171 |
| KEGG | hsa:8883 |
