HIT-result

Target Description

Type	Detail
Target ID	T06JXV
Protein Name	CD44 antigen
Uniprot ID	P16070
Protein Name Alias	CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD antigen CD44
Gene ID	960
Gene Symbol	CD44
Gene Alias	LHR; MDU2; MDU3; MIC4
TTD	T78319: Clinical Trial target
Pfam	PF00193
GO	0070062:extracellular exosome 0005902:microvillus 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0030667:secretory granule membrane 0009986:cell surface 0070487:monocyte aggregation 1900625:positive regulation of monocyte aggregation 0043066:negative regulation of apoptotic process 2000392:regulation of lamellipodium morphogenesis 0016477:cell migration 0033138:positive regulation of peptidyl-serine phosphorylation 0050900:leukocyte migration 0051216:cartilage development 0044344:cellular response to fibroblast growth factor stimulus 0005925:focal adhesion 0005829:cytosol 0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0060333:interferon-gamma-mediated signaling pathway 0031258:lamellipodium membrane 0035692:macrophage migration inhibitory factor receptor complex 0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator 0042110:T cell activation 0005794:Golgi apparatus 0005886:plasma membrane 0005540:hyaluronic acid binding 0007160:cell-matrix adhesion 0005887:integral component of plasma membrane 0022617:extracellular matrix disassembly 0034116:positive regulation of heterotypic cell-cell adhesion 0042995:cell projection 0043312:neutrophil degranulation 0005518:collagen binding 0098609:cell-cell adhesion 0016323:basolateral plasma membrane 0004888:transmembrane signaling receptor activity 0070374:positive regulation of ERK1 and ERK2 cascade 0044319:wound healing, spreading of cells 0030198:extracellular matrix organization 0006954:inflammatory response 1902166:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 0007155:cell adhesion 0030214:hyaluronan catabolic process 0016324:apical plasma membrane
PDB	4PZ4 ; 2I83 ; 1POZ ; 4PZ3 ; 1UUH ; 6TXS
Drugbank	DB08818 ; DB06550
KEGG	hsa:960

Type

Detail

Target ID

T06JXV

Protein Name

CD44 antigen

Uniprot ID

P16070

Protein Name Alias

CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD antigen CD44

Gene ID

960

Gene Symbol

CD44

Gene Alias

LHR; MDU2; MDU3; MIC4

TTD

T78319: Clinical Trial target

Pfam

PF00193

0070062:extracellular exosome

0005902:microvillus

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0030667:secretory granule membrane

0009986:cell surface

0070487:monocyte aggregation

1900625:positive regulation of monocyte aggregation

0043066:negative regulation of apoptotic process

2000392:regulation of lamellipodium morphogenesis

0016477:cell migration

0033138:positive regulation of peptidyl-serine phosphorylation

0050900:leukocyte migration

0051216:cartilage development

0044344:cellular response to fibroblast growth factor stimulus

0005925:focal adhesion

0005829:cytosol

0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0060333:interferon-gamma-mediated signaling pathway

0031258:lamellipodium membrane

0035692:macrophage migration inhibitory factor receptor complex

0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator

0042110:T cell activation

0005794:Golgi apparatus

0005886:plasma membrane

0005540:hyaluronic acid binding

0007160:cell-matrix adhesion

0005887:integral component of plasma membrane

0022617:extracellular matrix disassembly

0034116:positive regulation of heterotypic cell-cell adhesion

0042995:cell projection

0043312:neutrophil degranulation

0005518:collagen binding

0098609:cell-cell adhesion

0016323:basolateral plasma membrane

0004888:transmembrane signaling receptor activity

0070374:positive regulation of ERK1 and ERK2 cascade

0044319:wound healing, spreading of cells

0030198:extracellular matrix organization

0006954:inflammatory response

1902166:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0007155:cell adhesion

0030214:hyaluronan catabolic process

0016324:apical plasma membrane

PDB

4PZ4 ; 2I83 ; 1POZ ; 4PZ3 ; 1UUH ; 6TXS

Drugbank

DB08818 ; DB06550

KEGG

hsa:960

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0987	Bai Bu Jin Gao	百部浸膏	Tuber stemona	Stemona tuberosa
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0982	Bai Bu Gan Gao	百部干膏	Tuber stemona	Stemona tuberosa
H0991	Bai Bu Liu Jin Gao	百部流浸膏	Tuber stemona	Stemona tuberosa
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0077	Jiu	酒	Ethanol	Vinum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0977	Bai Bu	百部	Tuber stemona	Stemona tuberosa
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0738	Yi Xing Nan Wu Wei Zi	异型南五味子	Curious kadsura	Kadsura heteroclita
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0353	Que Mei Teng Gen	雀梅藤根	Hedge sageretia	Sageretia thea

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 23)