HIT-result

Target Description

Type	Detail
Target ID	T80D9C
Protein Name	Retinoic acid receptor gamma
Uniprot ID	P13631
Protein Name Alias	RAR-gamma; Nuclear receptor subfamily 1 group B member 3
Gene ID	5916
Gene Symbol	RARG
Gene Alias	NR1B3
TTD	T82146: Successful target
Pfam	PF00105 ; PF00104
GO	0003677:DNA binding 0005634:nucleus 0035264:multicellular organism growth 0032331:negative regulation of chondrocyte differentiation 0070384:Harderian gland development 0045637:regulation of myeloid cell differentiation 0003682:chromatin binding 0060534:trachea cartilage development 0008284:positive regulation of cell population proliferation 0008285:negative regulation of cell population proliferation 0032526:response to retinoic acid 0031076:embryonic camera-type eye development 0005737:cytoplasm 0002068:glandular epithelial cell development 0009755:hormone-mediated signaling pathway 0001843:neural tube closure 0030154:cell differentiation 0060070:canonical Wnt signaling pathway 0000785:chromatin 0016021:integral component of membrane 0035116:embryonic hindlimb morphogenesis 0009952:anterior/posterior pattern specification 0031641:regulation of myelination 0005667:transcription regulator complex 0048384:retinoic acid receptor signaling pathway 0060324:face development 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0043065:positive regulation of apoptotic process 0071300:cellular response to retinoic acid 0000122:negative regulation of transcription by RNA polymerase II 0008270:zinc ion binding 0003700:DNA-binding transcription factor activity 0003430:growth plate cartilage chondrocyte growth 0006367:transcription initiation from RNA polymerase II promoter 0046965:retinoid X receptor binding 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0005654:nucleoplasm 1990837:sequence-specific double-stranded DNA binding 0008361:regulation of cell size 0060740:prostate gland epithelium morphogenesis 1990830:cellular response to leukemia inhibitory factor 0045944:positive regulation of transcription by RNA polymerase II 0004879:nuclear receptor activity 0043068:positive regulation of programmed cell death 0048048:embryonic eye morphogenesis
PDB	3LBD ; 5M24 ; 1FCZ ; 2LBD ; 1EXA ; 1EXX ; 1FCX ; 1FD0 ; 1FCY ; 4LBD ; 6FX0
Drugbank	DB07031 ; DB03279 ; DB07294 ; DB02741 ; DB00982 ; DB00210 ; DB02258 ; DB00755 ; DB00799 ; DB00459 ; DB05467 ; DB02466 ; DB00523 ; DB05785 ; DB12808 ; DB03466 ; DB00926
KEGG	hsa:5916

Type

Detail

Target ID

T80D9C

Protein Name

Retinoic acid receptor gamma

Uniprot ID

P13631

Protein Name Alias

RAR-gamma; Nuclear receptor subfamily 1 group B member 3

Gene ID

5916

Gene Symbol

RARG

Gene Alias

NR1B3

TTD

T82146: Successful target

Pfam

PF00105 ; PF00104

0003677:DNA binding

0005634:nucleus

0035264:multicellular organism growth

0032331:negative regulation of chondrocyte differentiation

0070384:Harderian gland development

0045637:regulation of myeloid cell differentiation

0003682:chromatin binding

0060534:trachea cartilage development

0008284:positive regulation of cell population proliferation

0008285:negative regulation of cell population proliferation

0032526:response to retinoic acid

0031076:embryonic camera-type eye development

0005737:cytoplasm

0002068:glandular epithelial cell development

0009755:hormone-mediated signaling pathway

0001843:neural tube closure

0030154:cell differentiation

0060070:canonical Wnt signaling pathway

0000785:chromatin

0016021:integral component of membrane

0035116:embryonic hindlimb morphogenesis

0009952:anterior/posterior pattern specification

0031641:regulation of myelination

0005667:transcription regulator complex

0048384:retinoic acid receptor signaling pathway

0060324:face development

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0043065:positive regulation of apoptotic process

0071300:cellular response to retinoic acid

0000122:negative regulation of transcription by RNA polymerase II

0008270:zinc ion binding

0003700:DNA-binding transcription factor activity

0003430:growth plate cartilage chondrocyte growth

0006367:transcription initiation from RNA polymerase II promoter

0046965:retinoid X receptor binding

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0005654:nucleoplasm

1990837:sequence-specific double-stranded DNA binding

0008361:regulation of cell size

0060740:prostate gland epithelium morphogenesis

1990830:cellular response to leukemia inhibitory factor

0045944:positive regulation of transcription by RNA polymerase II

0004879:nuclear receptor activity

0043068:positive regulation of programmed cell death

0048048:embryonic eye morphogenesis

PDB

3LBD ; 5M24 ; 1FCZ ; 2LBD ; 1EXA ; 1EXX ; 1FCX ; 1FD0 ; 1FCY ; 4LBD ; 6FX0

Drugbank

DB07031 ; DB03279 ; DB07294 ; DB02741 ; DB00982 ; DB00210 ; DB02258 ; DB00755 ; DB00799 ; DB00459 ; DB05467 ; DB02466 ; DB00523 ; DB05785 ; DB12808 ; DB03466 ; DB00926

KEGG

hsa:5916

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0625	Ce Bai Tan	侧柏炭	Oriental arbor-vitae	Platycladus orientalis
H0247	Mi Meng Hua	密蒙花	Pale butterflybush	Buddleja officinalis
H1138	Bai Jiang Cao	败酱草	All - grass of dahurian patrinia	Thlaspi arvense
H0425	Shan Zhi Ma	山芝麻	Narrowleaf screwtree	Helicteres angustifolia
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0663	Xiao Ji	小蓟	Setose thistle	Cirsium setosum
H0729	Ye Ju Hua	野菊花	Indian wild chrysanthemum flower	Chrysanthemum indicum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0438	Shen Jin Cao	伸筋草	Common japanese clubmoss	Lycopodium japonicum
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0290	Niu Er Feng	牛耳枫	calyx-shaped daphniphyllum fruit	Daphniphyllum calycinum
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0426	Shan Zhi Ma Gan Jin Gao	山芝麻干浸膏	Narrowleaf screwtree	Helicteres angustifolia
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0073	Jing Jie Sui	荆芥穗	NA	Schizonepetae spica
H0002	Hui Xiang	茴香	Fennel fruit	Foeniculum vulgare

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 31)