Compound Description
| ID: C0845 | Common name: Acacetin |
| IUPAC: 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one | CAS: CAS:480-44-4 |
| Chembl ID: CHEMBL243664 | Pubchem ID: CID:5280442 |
| Formula: C16H12O5 | TCM-ID: TCMC606 |
| Smiles: COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O | |
| Alias:
Acacetin;
Flavone, 5,7-dihydroxy-4'-methoxy-; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; 4'-Methylapigenin; 4'-O-Methyl-5,7,4'-trihydroxyflavone; 4'-O-Methylapigenin; 5,7-Dihydroxy-4'-methoxyflavone; Apigenin 4'-methyl ether; Buddleoflavonol; LY 064233; Linarigenin; NSC 76061 |
Structure:
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Related Targets (Total: 21)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
A | 3 Reference(s) |
| T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
A | 1 Reference(s) |
| T62USB | Tumor necrosis factor receptor superfamily member 10A | TNFRSF10A |
O00220 |
A | 1 Reference(s) |
| T80D9C | Retinoic acid receptor gamma | RARG |
P13631 |
A | 1 Reference(s) |
| T88LSZ | Aromatase | CYP19A1 |
P11511 |
B | 1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
B | 1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
B | 2 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
B | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
C | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
C | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
C | 1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
C | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
C | 1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
C | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 29)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0004 | Huo Xiang | 藿香 | Patchouli | Pogostemon cablin |
| H0425 | Shan Zhi Ma | 山芝麻 | Narrowleaf screwtree | Helicteres angustifolia |
| H0247 | Mi Meng Hua | 密蒙花 | Pale butterflybush | Buddleja officinalis |
| H1161 | Hang Ju | 杭菊 | Chrysanthemum flower | Chrysanthemum morifolium |
| H0002 | Hui Xiang | 茴香 | Fennel fruit | Foeniculum vulgare |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H0625 | Ce Bai Tan | 侧柏炭 | Oriental arbor-vitae | Platycladus orientalis |
| H0572 | Tu Huo Xiang | 土藿香 | Patchouli | Pogostemon cablin |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H0426 | Shan Zhi Ma Gan Jin Gao | 山芝麻干浸膏 | Narrowleaf screwtree | Helicteres angustifolia |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1183 | Hong Dou | 红豆 | Hosie ormosia | Ormosia hosiei |
| H1010 | Du Huo Xiang | 杜藿香 | Patchouli | Pogostemon cablin |
| H0729 | Ye Ju Hua | 野菊花 | Indian wild chrysanthemum flower | Chrysanthemum indicum |
| H0073 | Jing Jie Sui | 荆芥穗 | NA | Schizonepetae spica |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H0370 | Ru Xiang | 乳香 | Olibanum | Boswellia carterii |
| H0290 | Niu Er Feng | 牛耳枫 | calyx-shaped daphniphyllum fruit | Daphniphyllum calycinum |
| H0092 | Ju Hua | 菊花 | Florists chrysanthemum flower | Chrysanthemum morifolium |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H1138 | Bai Jiang Cao | 败酱草 | All - grass of dahurian patrinia | Thlaspi arvense |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0438 | Shen Jin Cao | 伸筋草 | Common japanese clubmoss | Lycopodium japonicum |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0005 | Huo Xiang Ye | 藿香叶 | Patchouli | Pogostemon cablin |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
| H1120 | Guang Huo Xiang | 广藿香 | Patchouli | Pogostemon cablin |
Ckey description of the interaction between compound and target