HIT-result

Type	Detail
Target ID	T13DHC
Protein Name	Disintegrin and metalloproteinase domain-containing protein 10
Uniprot ID	O14672
Protein Name Alias	ADAM 10; EC 3.4.24.81; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD antigen CD156c
Gene ID	102
Gene Symbol	ADAM10
Gene Alias	KUZ; MADM
TTD	T31902: Clinical Trial target
Pfam	PF00200 ; PF01562
GO	0005178:integrin binding 0010629:negative regulation of gene expression 0009986:cell surface 0016021:integral component of membrane 0099173:postsynapse organization 0044267:cellular protein metabolic process 0046930:pore complex 0005102:signaling receptor binding 0005925:focal adhesion 0034205:amyloid-beta formation 0034332:adherens junction organization 0007219:Notch signaling pathway 0097038:perinuclear endoplasmic reticulum 0097060:synaptic membrane 0007283:spermatogenesis 0006509:membrane protein ectodomain proteolysis 1990000:amyloid fibril formation 0098978:glutamatergic synapse 0042117:monocyte activation 0042803:protein homodimerization activity 0005798:Golgi-associated vesicle 0007229:integrin-mediated signaling pathway 0043066:negative regulation of apoptotic process 0043025:neuronal cell body 0070821:tertiary granule membrane 0046872:metal ion binding 1901998:toxin transport 0097197:tetraspanin-enriched microdomain 0042987:amyloid precursor protein catabolic process 0061001:regulation of dendritic spine morphogenesis 0034612:response to tumor necrosis factor 0004175:endopeptidase activity 0008284:positive regulation of cell population proliferation 0008237:metallopeptidase activity 0007162:negative regulation of cell adhesion 0051089:constitutive protein ectodomain proteolysis 0014069:postsynaptic density 0030424:axon 0005912:adherens junction 0008593:regulation of Notch signaling pathway 0016020:membrane 0043197:dendritic spine 0098696:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane 0097327:response to antineoplastic agent 0043065:positive regulation of apoptotic process 0090102:cochlea development 0030307:positive regulation of cell growth 0005886:plasma membrane 0043687:post-translational protein modification 0022617:extracellular matrix disassembly 0005802:trans-Golgi network 0017124:SH3 domain binding 0005634:nucleus 0035333:Notch receptor processing, ligand-dependent 0019901:protein kinase binding 0046931:pore complex assembly 0005788:endoplasmic reticulum lumen 0035579:specific granule membrane 0071157:negative regulation of cell cycle arrest 0008021:synaptic vesicle 0010820:positive regulation of T cell chemotaxis 0070062:extracellular exosome 0006468:protein phosphorylation 0004222:metalloendopeptidase activity 1901342:regulation of vasculature development 0030136:clathrin-coated vesicle 0016485:protein processing 0005794:Golgi apparatus 0007267:cell-cell signaling 0001701:in utero embryonic development 0005737:cytoplasm 1902945:metalloendopeptidase activity involved in amyloid precursor protein catabolic process 0043312:neutrophil degranulation 0030335:positive regulation of cell migration 0045211:postsynaptic membrane 0000139:Golgi membrane 0043231:intracellular membrane-bounded organelle
PDB	6BDZ ; 6BE6 ; 1M1I
Drugbank	DB04991
KEGG	hsa:102

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens