Target Description

Type Detail
Target ID T09S1E
Protein Name Tumor necrosis factor alpha-induced protein 3
Uniprot ID P21580
Protein Name Alias TNF alpha-induced protein 3;  EC 2.3.2.-;  EC 3.4.19.12;  OTU domain-containing protein 7C;  Putative DNA-binding protein A20;  Zinc finger protein A20
Gene ID 7128
Gene Symbol TNFAIP3
Gene Alias OTUD7C
TTD T56474: Research target
Pfam PF02338 ; PF01754
GO
0003677:DNA binding

0042802:identical protein binding

0005634:nucleus

0004842:ubiquitin-protein transferase activity

0002634:regulation of germinal center formation

0070062:extracellular exosome

0070301:cellular response to hydrogen peroxide

0050869:negative regulation of B cell activation

0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling

0005829:cytosol

0045736:negative regulation of cyclin-dependent protein serine/threonine kinase activity

0010803:regulation of tumor necrosis factor-mediated signaling pathway

0045779:negative regulation of bone resorption

0035523:protein K29-linked deubiquitination

0070936:protein K48-linked ubiquitination

0070536:protein K63-linked deubiquitination

2000352:negative regulation of endothelial cell apoptotic process

0002237:response to molecule of bacterial origin

0071222:cellular response to lipopolysaccharide

0072666:establishment of protein localization to vacuole

0034144:negative regulation of toll-like receptor 4 signaling pathway

0006915:apoptotic process

0002677:negative regulation of chronic inflammatory response

0050691:regulation of defense response to virus by host

0061043:regulation of vascular wound healing

0048662:negative regulation of smooth muscle cell proliferation

0008234:cysteine-type peptidase activity

0071108:protein K48-linked deubiquitination

0031397:negative regulation of protein ubiquitination

0061578:Lys63-specific deubiquitinase activity

0090291:negative regulation of osteoclast proliferation

0070433:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

0034136:negative regulation of toll-like receptor 2 signaling pathway

0035871:protein K11-linked deubiquitination

1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

0019900:kinase binding

0032480:negative regulation of type I interferon production

0032495:response to muramyl dipeptide

0005764:lysosome

0070429:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

0070530:K63-linked polyubiquitin modification-dependent protein binding

0002020:protease binding

0004843:thiol-dependent ubiquitin-specific protease activity

0034148:negative regulation of toll-like receptor 5 signaling pathway

0050728:negative regulation of inflammatory response

0032088:negative regulation of NF-kappaB transcription factor activity

0006954:inflammatory response

0070423:nucleotide-binding oligomerization domain containing signaling pathway

2000349:negative regulation of CD40 signaling pathway

0045824:negative regulation of innate immune response

1903364:positive regulation of cellular protein catabolic process

0045732:positive regulation of protein catabolic process

2000347:positive regulation of hepatocyte proliferation

0072573:tolerance induction to lipopolysaccharide

0008270:zinc ion binding

0001922:B-1 B cell homeostasis

0034140:negative regulation of toll-like receptor 3 signaling pathway

0005737:cytoplasm

0032703:negative regulation of interleukin-2 production

0032720:negative regulation of tumor necrosis factor production

0008022:protein C-terminus binding

0030177:positive regulation of Wnt signaling pathway

0016477:cell migration

0016579:protein deubiquitination

0071947:protein deubiquitination involved in ubiquitin-dependent protein catabolic process

0032715:negative regulation of interleukin-6 production

1990168:protein K33-linked deubiquitination

0007010:cytoskeleton organization

0043130:ubiquitin binding

0032691:negative regulation of interleukin-1 beta production

0043621:protein self-association

PDB 5V3B ; 5V3P ; 3ZJD ; 3VUY ; 3ZJE ; 2EQG ; 3DKB ; 3OJ3 ; 3OJ4 ; 3VUX ; 3ZJF ; 2VFJ ; 3ZJG ; 5LRX ; 3VUW ; 2EQF ; 2EQE
Drugbank NA
KEGG hsa:7128

Related Compounds  (Total: 2)

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C0456
Name: Tretinoin
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C1237
Name: Chrysin


Related Herbs  (Total: 35)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0740 Yi Zhi益智 Fructus alpinae oxyphyllaeAlpinia oxyphylla
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0527 Tao PeachPrunus persica
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0743 Yi Zhi Ren益智仁 Sharpleaf galangalAlpinia oxyphylla
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H0409 Shan Jiang山姜 shell gingerAlpinia zerumbet
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1021 E Da Xia莪大夏 NAOxytropis falcata
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1223 Huai Hun Cao还魂草 NAAster tataricus