Compound Description
| ID: C1237 | Common name: Chrysin |
| IUPAC: 5,7-dihydroxy-2-phenylchromen-4-one | CAS: CAS:480-40-0 |
| Chembl ID: CHEMBL117 | Pubchem ID: CID:5281607 |
| Formula: C15H10O4 | TCM-ID: TCMC908 |
| Smiles: C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O | |
| Alias:
Chrysin;
Flavone, 5,7-dihydroxy-; 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-2-phenyl-4H-chromen-4-one; 5,7-Dihydroxy-2-phenylchromen-4-one; 5,7-Dihydroxyflavone; Crysin; NSC 407436 |
Structure:
|
Related Targets (Total: 35)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T88BCB | Glycerol-3-phosphate phosphatase | PGP |
A6NDG6 |
A | 1 Reference(s) |
| T32R5L | Cyclin-dependent kinase 9 | CDK9 |
P50750 |
A | 1 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
A | 1 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
A | 1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
A | 1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
A | 2 Reference(s) |
| T68DAN | Histone deacetylase 9 | HDAC9 |
Q9UKV0 |
A | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
A | 3 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
A | 2 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
A | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
A | 1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
A | 1 Reference(s) |
| T90RVD | Histone deacetylase 8 | HDAC8 |
Q9BY41 |
A | 1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
A | 1 Reference(s) |
| T60GGR | Serine/threonine-protein kinase TBK1 | TBK1 |
Q9UHD2 |
B | 1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
B | 1 Reference(s) |
| T50GQE | Interleukin-13 | IL13 |
P35225 |
B | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
B | 2 Reference(s) |
| T88LSZ | Aromatase | CYP19A1 |
P11511 |
B | 1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
B | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
B | 1 Reference(s) |
| T18F9A | Glycophorin-B | GYPB |
P06028 |
B | 1 Reference(s) |
| T88HDQ | Tyrosine-protein phosphatase non-receptor type 13 | PTPN13 |
Q12923 |
B | 1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
B | 1 Reference(s) |
| T39WPZ | Mitogen-activated protein kinase 9 | MAPK9 |
P45984 |
B | 1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
C | 1 Reference(s) |
| T01D27 | Eukaryotic translation initiation factor 6 | EIF6 |
P56537 |
C | 1 Reference(s) |
| T09S1E | Tumor necrosis factor alpha-induced protein 3 | TNFAIP3 |
P21580 |
C | 1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
C | 1 Reference(s) |
| T87QUW | Actin, aortic smooth muscle | ACTA2 |
P62736 |
C | 1 Reference(s) |
| T52H3P | Claudin-1 | CLDN1 |
O95832 |
C | 1 Reference(s) |
| T75KZ8 | Claudin-11 | CLDN11 |
O75508 |
C | 1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
C | 1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 33)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0740 | Yi Zhi | 益智 | Fructus alpinae oxyphyllae | Alpinia oxyphylla |
| H0250 | Mi Zi Wan | 蜜紫菀 | Tatarian aster | Aster tataricus |
| H0527 | Tao | 桃 | Peach | Prunus persica |
| H0816 | Chu Ling Dan | 臭灵丹 | laggera pterodonta | Laggera pterodonta |
| H0743 | Yi Zhi Ren | 益智仁 | Sharpleaf galangal | Alpinia oxyphylla |
| H0821 | Chu Ling Dan Cao | 臭灵丹草 | laggera pterodonta | Laggera pterodonta |
| H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
| H0583 | Tu Si Zi Teng | 菟丝子藤 | Dodder seed | Cuscuta australis |
| H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
| H1152 | Bai Jie Zi | 白芥子 | White mustard seed | Sinapis alba |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
| H1026 | Fan Hun Cao | 返魂草 | Tatarian aster | Aster tataricus |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0531 | Tao Zhi | 桃枝 | Peach juvenile branch | Prunus persica |
| H0581 | Tu Si Zi | 菟丝子 | Dodder seed | Cuscuta australis |
| H0409 | Shan Jiang | 山姜 | shell ginger | Alpinia zerumbet |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1161 | Hang Ju | 杭菊 | Chrysanthemum flower | Chrysanthemum morifolium |
| H0529 | Tao Ren | 桃仁 | Peach kernel | Prunus persica |
| H1183 | Hong Dou | 红豆 | Hosie ormosia | Ormosia hosiei |
| H0853 | Zi Wan | 紫菀 | Tatarion aster | Aster tataricus |
| H0092 | Ju Hua | 菊花 | Florists chrysanthemum flower | Chrysanthemum morifolium |
| H0582 | Cao Dou Kou Ren | 草豆蔻仁 | Katsumada galangal | Alpinia katsumadai |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0580 | Tu Si Rou | 菟丝肉 | Dodder seed | Cuscuta australis |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1021 | E Da Xia | 莪大夏 | NA | Oxytropis falcata |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0574 | Cao Dou Kou | 草豆蔻 | Katsumada galangal | Alpinia katsumadai |
| H0530 | Tao Ren Shuang | 桃仁霜 | Peach kernel | Prunus persica |
| H1223 | Huai Hun Cao | 还魂草 | NA | Aster tataricus |
Ckey description of the interaction between compound and target