Target Description

Type Detail
Target ID T90RVD
Protein Name Histone deacetylase 8
Uniprot ID Q9BY41
Protein Name Alias HD8;  EC 3.5.1.98
Gene ID 55869
Gene Symbol HDAC8
Gene Alias HDACL1
TTD T28887: Clinical Trial target
Pfam PF00850
GO
0008134:transcription factor binding

0005634:nucleus

0000228:nuclear chromosome

0004407:histone deacetylase activity

0000118:histone deacetylase complex

0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)

0031397:negative regulation of protein ubiquitination

0051879:Hsp90 protein binding

0005886:plasma membrane

0070933:histone H4 deacetylation

0071922:regulation of cohesin loading

0007062:sister chromatid cohesion

0070932:histone H3 deacetylation

0000122:negative regulation of transcription by RNA polymerase II

0005737:cytoplasm

0032204:regulation of telomere maintenance

0005654:nucleoplasm

0046872:metal ion binding

0031647:regulation of protein stability

0045944:positive regulation of transcription by RNA polymerase II

0030544:Hsp70 protein binding

0006333:chromatin assembly or disassembly

0006325:chromatin organization

PDB 3EW8 ; 7JVU ; 5DC6 ; 6HSK ; 1W22 ; 3MZ6 ; 5THV ; 1T67 ; 4QA6 ; 6ODC ; 5THU ; 2V5W ; 3F07 ; 3SFF ; 5THS ; 7JVW ; 3MZ7 ; 3F0R ; 4QA7 ; 4RN2 ; 4QA0 ; 2V5X ; 5D1D ; 3RQD ; 4QA4 ; 5VI6 ; 5DC5 ; 1T64 ; 1VKG ; 4QA2 ; 5BWZ ; 5DC7 ; 5THT ; 5FCW ; 7JVV ; 3EZP ; 5D1B ; 4QA3 ; 3MZ4 ; 3EWF ; 4RN0 ; 3F06 ; 4RN1 ; 4QA1 ; 1T69 ; 3MZ3 ; 4QA5 ; 3SFH ; 6ODB ; 3EZT ; 5D1C ; 6ODA ; 5DC8
Drugbank DB08168 ; DB02546 ; DB01593 ; DB07586 ; DB06603 ; DB14501 ; DB04297 ; DB14548 ; DB05015 ; DB14490 ; DB14533 ; DB02565 ; DB14488 ; DB14491 ; DB07350 ; DB01592 ; DB14487 ; DB14489 ; DB02917
KEGG hsa:55869

Related Compounds  (Total: 2)

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C0477
Name: Valproic Acid
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C1237
Name: Chrysin


Related Herbs  (Total: 35)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0743 Yi Zhi Ren益智仁 Sharpleaf galangalAlpinia oxyphylla
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H1021 E Da Xia莪大夏 NAOxytropis falcata
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1223 Huai Hun Cao还魂草 NAAster tataricus
H0740 Yi Zhi益智 Fructus alpinae oxyphyllaeAlpinia oxyphylla
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0409 Shan Jiang山姜 shell gingerAlpinia zerumbet
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0527 Tao PeachPrunus persica
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis