HIT-result

Type	Detail
Target ID	T03O7G
Protein Name	Orexin
Uniprot ID	O43612
Protein Name Alias	Hypocretin; Hcrt
Gene ID	3060
Gene Symbol	HCRT
Gene Alias	OX; PPORX; PPOX
TTD	T60744: Research target
Pfam	PF02072
GO	0031771:type 1 hypocretin receptor binding 0060079:excitatory postsynaptic potential 0051971:positive regulation of transmission of nerve impulse 0007205:protein kinase C-activating G protein-coupled receptor signaling pathway 0043267:negative regulation of potassium ion transport 0005791:rough endoplasmic reticulum 0120162:positive regulation of cold-induced thermogenesis 0030431:sleep 0007268:chemical synaptic transmission 0007186:G protein-coupled receptor signaling pathway 0001659:temperature homeostasis 0008156:negative regulation of DNA replication 0042594:response to starvation 0051928:positive regulation of calcium ion transport 0051970:negative regulation of transmission of nerve impulse 0098794:postsynapse 0030141:secretory granule 0048471:perinuclear region of cytoplasm 0007218:neuropeptide signaling pathway 0042755:eating behavior 0031772:type 2 hypocretin receptor binding 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0005576:extracellular region 0046928:regulation of neurotransmitter secretion 0005184:neuropeptide hormone activity 0008021:synaptic vesicle 0007204:positive regulation of cytosolic calcium ion concentration
PDB	1R02 ; 1WSO ; 1UVQ ; 1CQ0
Drugbank	DB03088
KEGG	hsa:3060

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description