HIT-result

Target Description

Type	Detail
Target ID	T75OVL
Protein Name	High affinity nerve growth factor receptor
Uniprot ID	P04629
Protein Name Alias	EC 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA
Gene ID	4914
Gene Symbol	NTRK1
Gene Alias	MTC; TRK; TRKA
TTD	T07173: Successful target
Pfam	PF07714 ; PF13855 ; PF18613 ; PF16920
GO	0007275:multicellular organism development 0001934:positive regulation of protein phosphorylation 0032991:protein-containing complex 0042803:protein homodimerization activity 0060385:axonogenesis involved in innervation 0048485:sympathetic nervous system development 0043410:positive regulation of MAPK cascade 0006468:protein phosphorylation 0005524:ATP binding 0042490:mechanoreceptor differentiation 0038083:peptidyl-tyrosine autophosphorylation 0043235:receptor complex 0000186:activation of MAPKK activity 0005770:late endosome 0010465:nerve growth factor receptor activity 0005887:integral component of plasma membrane 0007411:axon guidance 0045766:positive regulation of angiogenesis 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0004713:protein tyrosine kinase activity 0009986:cell surface 0008285:negative regulation of cell population proliferation 0010008:endosome membrane 0048666:neuron development 0070374:positive regulation of ERK1 and ERK2 cascade 0048678:response to axon injury 0005886:plasma membrane 0046777:protein autophosphorylation 0042493:response to drug 0030424:axon 0031901:early endosome membrane 0051602:response to electrical stimulus 0019900:kinase binding 0055038:recycling endosome membrane 0048015:phosphatidylinositol-mediated signaling 0030425:dendrite 0005030:neurotrophin receptor activity 0021553:olfactory nerve development 0005004:GPI-linked ephrin receptor activity 0043524:negative regulation of neuron apoptotic process 0043066:negative regulation of apoptotic process 0042802:identical protein binding 0009314:response to radiation 0031667:response to nutrient levels 0004714:transmembrane receptor protein tyrosine kinase activity 0031175:neuron projection development 0038180:nerve growth factor signaling pathway 1990090:cellular response to nerve growth factor stimulus 0051965:positive regulation of synapse assembly 0050965:detection of temperature stimulus involved in sensory perception of pain 0007568:aging 0051968:positive regulation of synaptic transmission, glutamatergic 0030183:B cell differentiation 0046579:positive regulation of Ras protein signal transduction 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0050966:detection of mechanical stimulus involved in sensory perception of pain 0007623:circadian rhythm 0071316:cellular response to nicotine 0010976:positive regulation of neuron projection development 0018108:peptidyl-tyrosine phosphorylation 0051896:regulation of protein kinase B signaling 0007611:learning or memory 0048011:neurotrophin TRK receptor signaling pathway 0043068:positive regulation of programmed cell death 0005166:neurotrophin p75 receptor binding 0033674:positive regulation of kinase activity 0031902:late endosome membrane 0043121:neurotrophin binding 0061368:behavioral response to formalin induced pain 0010623:programmed cell death involved in cell development 0051599:response to hydrostatic pressure 0043025:neuronal cell body 0043547:positive regulation of GTPase activity 0005769:early endosome 0048406:nerve growth factor binding 0051092:positive regulation of NF-kappaB transcription factor activity 0060009:Sertoli cell development
PDB	6D1Z ; 6J5L ; 6DKW ; 4F0I ; 5I8A ; 5JFX ; 5KMM ; 5WR7 ; 6DKB ; 6DKG ; 6NSS ; 2N90 ; 4PMP ; 6D22 ; 1SHC ; 5KMK ; 6D20 ; 5KMO ; 6PMA ; 4AOJ ; 5KMJ ; 6PMB ; 5KML ; 4PMM ; 6PL1 ; 6NSP ; 6D1Y ; 6PME ; 5JFS ; 4PMS ; 4CRP ; 5KMI ; 5JFV ; 1WWW ; 1WWA ; 1HE7 ; 6NPT ; 6PL3 ; 5H3Q ; 6IQN ; 6DKI ; 6PL4 ; 2IFG ; 4GT5 ; 4YNE ; 5KVT ; 6PMC ; 5KMN ; 6PL2 ; 4PMT ; 5JFW ; 4YPS
Drugbank	DB14723 ; DB00619 ; DB13926 ; DB08896 ; DB11986 ; DB12010 ; DB00321 ; DB15822
KEGG	hsa:4914

Type

Detail

Target ID

T75OVL

Protein Name

High affinity nerve growth factor receptor

Uniprot ID

P04629

Protein Name Alias

EC 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA

Gene ID

4914

Gene Symbol

NTRK1

Gene Alias

MTC; TRK; TRKA

TTD

T07173: Successful target

Pfam

PF07714 ; PF13855 ; PF18613 ; PF16920

0007275:multicellular organism development

0001934:positive regulation of protein phosphorylation

0032991:protein-containing complex

0042803:protein homodimerization activity

0060385:axonogenesis involved in innervation

0048485:sympathetic nervous system development

0043410:positive regulation of MAPK cascade

0006468:protein phosphorylation

0005524:ATP binding

0042490:mechanoreceptor differentiation

0038083:peptidyl-tyrosine autophosphorylation

0043235:receptor complex

0000186:activation of MAPKK activity

0005770:late endosome

0010465:nerve growth factor receptor activity

0005887:integral component of plasma membrane

0007411:axon guidance

0045766:positive regulation of angiogenesis

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0004713:protein tyrosine kinase activity

0009986:cell surface

0008285:negative regulation of cell population proliferation

0010008:endosome membrane

0048666:neuron development

0070374:positive regulation of ERK1 and ERK2 cascade

0048678:response to axon injury

0005886:plasma membrane

0046777:protein autophosphorylation

0042493:response to drug

0030424:axon

0031901:early endosome membrane

0051602:response to electrical stimulus

0019900:kinase binding

0055038:recycling endosome membrane

0048015:phosphatidylinositol-mediated signaling

0030425:dendrite

0005030:neurotrophin receptor activity

0021553:olfactory nerve development

0005004:GPI-linked ephrin receptor activity

0043524:negative regulation of neuron apoptotic process

0043066:negative regulation of apoptotic process

0042802:identical protein binding

0009314:response to radiation

0031667:response to nutrient levels

0004714:transmembrane receptor protein tyrosine kinase activity

0031175:neuron projection development

0038180:nerve growth factor signaling pathway

1990090:cellular response to nerve growth factor stimulus

0051965:positive regulation of synapse assembly

0050965:detection of temperature stimulus involved in sensory perception of pain

0007568:aging

0051968:positive regulation of synaptic transmission, glutamatergic

0030183:B cell differentiation

0046579:positive regulation of Ras protein signal transduction

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0050966:detection of mechanical stimulus involved in sensory perception of pain

0007623:circadian rhythm

0071316:cellular response to nicotine

0010976:positive regulation of neuron projection development

0018108:peptidyl-tyrosine phosphorylation

0051896:regulation of protein kinase B signaling

0007611:learning or memory

0048011:neurotrophin TRK receptor signaling pathway

0043068:positive regulation of programmed cell death

0005166:neurotrophin p75 receptor binding

0033674:positive regulation of kinase activity

0031902:late endosome membrane

0043121:neurotrophin binding

0061368:behavioral response to formalin induced pain

0010623:programmed cell death involved in cell development

0051599:response to hydrostatic pressure

0043025:neuronal cell body

0043547:positive regulation of GTPase activity

0005769:early endosome

0048406:nerve growth factor binding

0051092:positive regulation of NF-kappaB transcription factor activity

0060009:Sertoli cell development

PDB

6D1Z ; 6J5L ; 6DKW ; 4F0I ; 5I8A ; 5JFX ; 5KMM ; 5WR7 ; 6DKB ; 6DKG ; 6NSS ; 2N90 ; 4PMP ; 6D22 ; 1SHC ; 5KMK ; 6D20 ; 5KMO ; 6PMA ; 4AOJ ; 5KMJ ; 6PMB ; 5KML ; 4PMM ; 6PL1 ; 6NSP ; 6D1Y ; 6PME ; 5JFS ; 4PMS ; 4CRP ; 5KMI ; 5JFV ; 1WWW ; 1WWA ; 1HE7 ; 6NPT ; 6PL3 ; 5H3Q ; 6IQN ; 6DKI ; 6PL4 ; 2IFG ; 4GT5 ; 4YNE ; 5KVT ; 6PMC ; 5KMN ; 6PL2 ; 4PMT ; 5JFW ; 4YPS

Drugbank

DB14723 ; DB00619 ; DB13926 ; DB08896 ; DB11986 ; DB12010 ; DB00321 ; DB15822

KEGG

hsa:4914

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 13)