HIT-result

Target Description

Type	Detail
Target ID	T85HMF
Protein Name	Metalloproteinase inhibitor 3
Uniprot ID	P35625
Protein Name Alias	Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
Gene ID	7078
Gene Symbol	TIMP3
Gene Alias	NA
TTD	NA
Pfam	PF00965
GO	0031012:extracellular matrix 0005615:extracellular space 0002576:platelet degranulation 0046872:metal ion binding 0070373:negative regulation of ERK1 and ERK2 cascade 0010951:negative regulation of endopeptidase activity 0009725:response to hormone 0007601:visual perception 1903984:positive regulation of TRAIL-activated apoptotic signaling pathway 0005576:extracellular region 1904684:negative regulation of metalloendopeptidase activity 0034097:response to cytokine 0031089:platelet dense granule lumen 0005634:nucleus 0002020:protease binding 0062023:collagen-containing extracellular matrix 0010033:response to organic substance 0051045:negative regulation of membrane protein ectodomain proteolysis 0008191:metalloendopeptidase inhibitor activity
PDB	3CKI
Drugbank	DB05383
KEGG	hsa:7078

Type

Detail

Target ID

T85HMF

Protein Name

Metalloproteinase inhibitor 3

Uniprot ID

P35625

Protein Name Alias

Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3

Gene ID

7078

Gene Symbol

TIMP3

Gene Alias

TTD

Pfam

PF00965

0031012:extracellular matrix

0005615:extracellular space

0002576:platelet degranulation

0046872:metal ion binding

0070373:negative regulation of ERK1 and ERK2 cascade

0010951:negative regulation of endopeptidase activity

0009725:response to hormone

0007601:visual perception

1903984:positive regulation of TRAIL-activated apoptotic signaling pathway

0005576:extracellular region

1904684:negative regulation of metalloendopeptidase activity

0034097:response to cytokine

0031089:platelet dense granule lumen

0005634:nucleus

0002020:protease binding

0062023:collagen-containing extracellular matrix

0010033:response to organic substance

0051045:negative regulation of membrane protein ectodomain proteolysis

0008191:metalloendopeptidase inhibitor activity

PDB

3CKI

Drugbank

DB05383

KEGG

hsa:7078

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 17)