HIT-result

Target Description

Type	Detail
Target ID	T82RFG
Protein Name	P2Y purinoceptor 12
Uniprot ID	Q9H244
Protein Name Alias	P2Y12; ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999
Gene ID	64805
Gene Symbol	P2RY12
Gene Alias	HORK3
TTD	T46937: Successful target
Pfam	PF00001
GO	0030168:platelet activation 0021808:cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration 0045596:negative regulation of cell differentiation 0043270:positive regulation of ion transport 0009986:cell surface 0016021:integral component of membrane 0071805:potassium ion transmembrane transport 0043491:protein kinase B signaling 0071318:cellular response to ATP 0070527:platelet aggregation 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0050920:regulation of chemotaxis 0007186:G protein-coupled receptor signaling pathway 0035585:calcium-mediated signaling using extracellular calcium source 0009897:external side of plasma membrane 0031224:intrinsic component of membrane 0043552:positive regulation of phosphatidylinositol 3-kinase activity 1904141:positive regulation of microglial cell migration 0030030:cell projection organization 0050921:positive regulation of chemotaxis 0005886:plasma membrane 1904139:regulation of microglial cell migration 0051924:regulation of calcium ion transport 0150063:visual system development 0033626:positive regulation of integrin activation by cell surface receptor linked signal transduction 0001621:G protein-coupled ADP receptor activity 0030032:lamellipodium assembly 1900029:positive regulation of ruffle assembly 0005739:mitochondrion 0007599:hemostasis 0009925:basal plasma membrane 0044298:cell body membrane 0048678:response to axon injury 0070588:calcium ion transmembrane transport 0045028:G protein-coupled purinergic nucleotide receptor activity 0010700:negative regulation of norepinephrine secretion 0005901:caveola 0033630:positive regulation of cell adhesion mediated by integrin 1904124:microglial cell migration 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0031253:cell projection membrane 0001609:G protein-coupled adenosine receptor activity 0006930:substrate-dependent cell migration, cell extension 0051897:positive regulation of protein kinase B signaling 0019722:calcium-mediated signaling 0007202:activation of phospholipase C activity
PDB	1Y9C ; 4NTJ ; 4PY0 ; 4PXZ ; 1VZ1 ; 1T78
Drugbank	DB06350 ; DB06441 ; DB01069 ; DB00374 ; DB00758 ; DB01240 ; DB06209 ; DB05553 ; DB00208 ; DB08816
KEGG	hsa:64805

Type

Detail

Target ID

T82RFG

Protein Name

P2Y purinoceptor 12

Uniprot ID

Q9H244

Protein Name Alias

P2Y12; ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999

Gene ID

64805

Gene Symbol

P2RY12

Gene Alias

HORK3

TTD

T46937: Successful target

Pfam

PF00001

0030168:platelet activation

0021808:cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration

0045596:negative regulation of cell differentiation

0043270:positive regulation of ion transport

0009986:cell surface

0016021:integral component of membrane

0071805:potassium ion transmembrane transport

0043491:protein kinase B signaling

0071318:cellular response to ATP

0070527:platelet aggregation

0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

0050920:regulation of chemotaxis

0007186:G protein-coupled receptor signaling pathway

0035585:calcium-mediated signaling using extracellular calcium source

0009897:external side of plasma membrane

0031224:intrinsic component of membrane

0043552:positive regulation of phosphatidylinositol 3-kinase activity

1904141:positive regulation of microglial cell migration

0030030:cell projection organization

0050921:positive regulation of chemotaxis

0005886:plasma membrane

1904139:regulation of microglial cell migration

0051924:regulation of calcium ion transport

0150063:visual system development

0033626:positive regulation of integrin activation by cell surface receptor linked signal transduction

0001621:G protein-coupled ADP receptor activity

0030032:lamellipodium assembly

1900029:positive regulation of ruffle assembly

0005739:mitochondrion

0007599:hemostasis

0009925:basal plasma membrane

0044298:cell body membrane

0048678:response to axon injury

0070588:calcium ion transmembrane transport

0045028:G protein-coupled purinergic nucleotide receptor activity

0010700:negative regulation of norepinephrine secretion

0005901:caveola

0033630:positive regulation of cell adhesion mediated by integrin

1904124:microglial cell migration

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0031253:cell projection membrane

0001609:G protein-coupled adenosine receptor activity

0006930:substrate-dependent cell migration, cell extension

0051897:positive regulation of protein kinase B signaling

0019722:calcium-mediated signaling

0007202:activation of phospholipase C activity

PDB

1Y9C ; 4NTJ ; 4PY0 ; 4PXZ ; 1VZ1 ; 1T78

Drugbank

DB06350 ; DB06441 ; DB01069 ; DB00374 ; DB00758 ; DB01240 ; DB06209 ; DB05553 ; DB00208 ; DB08816

KEGG

hsa:64805

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 12)