HIT-result

Target Description

Type	Detail
Target ID	T15VAS
Protein Name	Integrin beta-1
Uniprot ID	P05556
Protein Name Alias	Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD antigen CD29
Gene ID	3688
Gene Symbol	ITGB1
Gene Alias	FNRB; MDF2; MSK12
TTD	T01851: Clinical Trial target
Pfam	PF08725 ; PF17205 ; PF00362 ; PF07965 ; PF07974 ; PF18372
GO	0005178:integrin binding 0051951:positive regulation of glutamate uptake involved in transmission of nerve impulse 0034680:integrin alpha10-beta1 complex 0005925:focal adhesion 0034113:heterotypic cell-cell adhesion 0150003:regulation of spontaneous synaptic transmission 0050776:regulation of immune response 0030030:cell projection organization 0006968:cellular defense response 0034668:integrin alpha4-beta1 complex 0007160:cell-matrix adhesion 0034665:integrin alpha1-beta1 complex 0050901:leukocyte tethering or rolling 0030032:lamellipodium assembly 0019221:cytokine-mediated signaling pathway 1903078:positive regulation of protein localization to plasma membrane 0034681:integrin alpha11-beta1 complex 0045296:cadherin binding 0050839:cell adhesion molecule binding 0150103:reactive gliosis 2000811:negative regulation of anoikis 0034678:integrin alpha8-beta1 complex 0007229:integrin-mediated signaling pathway 0010710:regulation of collagen catabolic process 0055037:recycling endosome 0016477:cell migration 0007156:homophilic cell adhesion via plasma membrane adhesion molecules 0009986:cell surface 0031594:neuromuscular junction 0043547:positive regulation of GTPase activity 0046872:metal ion binding 0034666:integrin alpha2-beta1 complex 0001618:virus receptor activity 0097386:glial cell projection 0001726:ruffle 0010763:positive regulation of fibroblast migration 0007155:cell adhesion 0031623:receptor internalization 0030175:filopodium 0051897:positive regulation of protein kinase B signaling 0006909:phagocytosis 0042470:melanosome 0033627:cell adhesion mediated by integrin 0001968:fibronectin binding 0016020:membrane 0032154:cleavage furrow 0046718:viral entry into host cell 0043065:positive regulation of apoptotic process 0071404:cellular response to low-density lipoprotein particle stimulus 0005886:plasma membrane 0033631:cell-cell adhesion mediated by integrin 0032587:ruffle membrane 0034667:integrin alpha3-beta1 complex 0090303:positive regulation of wound healing 0031589:cell-substrate adhesion 0002020:protease binding 1901979:regulation of inward rectifier potassium channel activity 0015026:coreceptor activity 0003779:actin binding 0030183:B cell differentiation 0070062:extracellular exosome 0023035:CD40 signaling pathway 0019058:viral life cycle 1990782:protein tyrosine kinase binding 0050900:leukocyte migration 0007161:calcium-independent cell-matrix adhesion 0046982:protein heterodimerization activity 0007159:leukocyte cell-cell adhesion 0044877:protein-containing complex binding 0048333:mesodermal cell differentiation 0042383:sarcolemma 0005737:cytoplasm 0098639:collagen binding involved in cell-matrix adhesion 0030335:positive regulation of cell migration 0034674:integrin alpha5-beta1 complex 0043235:receptor complex 0000132:establishment of mitotic spindle orientation 0035633:maintenance of blood-brain barrier 0045766:positive regulation of angiogenesis 0010008:endosome membrane 0045121:membrane raft 0030198:extracellular matrix organization 2000273:positive regulation of signaling receptor activity 0030027:lamellipodium
PDB	4WK2 ; 3VI4 ; 1LHA ; 1K11 ; 4WJK ; 4WK4 ; 3T9K ; 3G9W ; 3VI3 ; 4WK0 ; 4DX9
Drugbank	DB15791 ; DB00098
KEGG	hsa:3688

Type

Detail

Target ID

T15VAS

Protein Name

Integrin beta-1

Uniprot ID

P05556

Protein Name Alias

Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD antigen CD29

Gene ID

3688

Gene Symbol

ITGB1

Gene Alias

FNRB; MDF2; MSK12

TTD

T01851: Clinical Trial target

Pfam

PF08725 ; PF17205 ; PF00362 ; PF07965 ; PF07974 ; PF18372

0005178:integrin binding

0051951:positive regulation of glutamate uptake involved in transmission of nerve impulse

0034680:integrin alpha10-beta1 complex

0005925:focal adhesion

0034113:heterotypic cell-cell adhesion

0150003:regulation of spontaneous synaptic transmission

0050776:regulation of immune response

0030030:cell projection organization

0006968:cellular defense response

0034668:integrin alpha4-beta1 complex

0007160:cell-matrix adhesion

0034665:integrin alpha1-beta1 complex

0050901:leukocyte tethering or rolling

0030032:lamellipodium assembly

0019221:cytokine-mediated signaling pathway

1903078:positive regulation of protein localization to plasma membrane

0034681:integrin alpha11-beta1 complex

0045296:cadherin binding

0050839:cell adhesion molecule binding

0150103:reactive gliosis

2000811:negative regulation of anoikis

0034678:integrin alpha8-beta1 complex

0007229:integrin-mediated signaling pathway

0010710:regulation of collagen catabolic process

0055037:recycling endosome

0016477:cell migration

0007156:homophilic cell adhesion via plasma membrane adhesion molecules

0009986:cell surface

0031594:neuromuscular junction

0043547:positive regulation of GTPase activity

0046872:metal ion binding

0034666:integrin alpha2-beta1 complex

0001618:virus receptor activity

0097386:glial cell projection

0001726:ruffle

0010763:positive regulation of fibroblast migration

0007155:cell adhesion

0031623:receptor internalization

0030175:filopodium

0051897:positive regulation of protein kinase B signaling

0006909:phagocytosis

0042470:melanosome

0033627:cell adhesion mediated by integrin

0001968:fibronectin binding

0016020:membrane

0032154:cleavage furrow

0046718:viral entry into host cell

0043065:positive regulation of apoptotic process

0071404:cellular response to low-density lipoprotein particle stimulus

0005886:plasma membrane

0033631:cell-cell adhesion mediated by integrin

0032587:ruffle membrane

0034667:integrin alpha3-beta1 complex

0090303:positive regulation of wound healing

0031589:cell-substrate adhesion

0002020:protease binding

1901979:regulation of inward rectifier potassium channel activity

0015026:coreceptor activity

0003779:actin binding

0030183:B cell differentiation

0070062:extracellular exosome

0023035:CD40 signaling pathway

0019058:viral life cycle

1990782:protein tyrosine kinase binding

0050900:leukocyte migration

0007161:calcium-independent cell-matrix adhesion

0046982:protein heterodimerization activity

0007159:leukocyte cell-cell adhesion

0044877:protein-containing complex binding

0048333:mesodermal cell differentiation

0042383:sarcolemma

0005737:cytoplasm

0098639:collagen binding involved in cell-matrix adhesion

0030335:positive regulation of cell migration

0034674:integrin alpha5-beta1 complex

0043235:receptor complex

0000132:establishment of mitotic spindle orientation

0035633:maintenance of blood-brain barrier

0045766:positive regulation of angiogenesis

0010008:endosome membrane

0045121:membrane raft

0030198:extracellular matrix organization

2000273:positive regulation of signaling receptor activity

0030027:lamellipodium

PDB

4WK2 ; 3VI4 ; 1LHA ; 1K11 ; 4WJK ; 4WK4 ; 3T9K ; 3G9W ; 3VI3 ; 4WK0 ; 4DX9

Drugbank

DB15791 ; DB00098

KEGG

hsa:3688

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0228	Mang Xiao	芒硝	Sodium sulfate	Natrii sulfas
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1125	Guang Ming Yan	光明盐	Salt	Sal
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0936	Da Qing Yan	大青盐	NA	Halitum
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0469	Shi Yan	食盐	Salt	Sal
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum

Target Description

Related Compounds (Total: 6)

Related Herbs (Total: 46)