HIT-result

Type	Detail
Target ID	T01E8J
Protein Name	Amyloid-beta precursor protein
Uniprot ID	P05067
Protein Name Alias	APP; ABPP; APPI; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II
Gene ID	351
Gene Symbol	APP
Gene Alias	A4; AD1
TTD	T87024: Successful target
Pfam	PF10515 ; PF12925 ; PF02177 ; PF12924 ; PF03494 ; PF00014
GO	0005178:integrin binding 0070851:growth factor receptor binding 0032731:positive regulation of interleukin-1 beta production 0045048:protein insertion into ER membrane 0032991:protein-containing complex 0010629:negative regulation of gene expression 0007176:regulation of epidermal growth factor-activated receptor activity 0009986:cell surface 0016021:integral component of membrane 0016358:dendrite development 0045666:positive regulation of neuron differentiation 0030546:signaling receptor activator activity 0032722:positive regulation of chemokine production 0050803:regulation of synapse structure or activity 0044267:cellular protein metabolic process 1900221:regulation of amyloid-beta clearance 0097645:amylin binding 0014005:microglia development 0051402:neuron apoptotic process 0051247:positive regulation of protein metabolic process 1905893:positive regulation of cellular response to thapsigargin 0007186:G protein-coupled receptor signaling pathway 0003682:chromatin binding 0007612:learning 2000463:positive regulation of excitatory postsynaptic potential 0034364:high-density lipoprotein particle 0005102:signaling receptor binding 1905945:regulation of response to calcium ion 0040014:regulation of multicellular organism growth 0098815:modulation of excitatory postsynaptic potential 0150003:regulation of spontaneous synaptic transmission 0035066:positive regulation of histone acetylation 0045745:positive regulation of G protein-coupled receptor signaling pathway 0010800:positive regulation of peptidyl-threonine phosphorylation 0005576:extracellular region 0007219:Notch signaling pathway 0051260:protein homooligomerization 0046875:ephrin receptor binding 0010288:response to lead ion 0071320:cellular response to cAMP 0044304:main axon 1902894:negative regulation of pri-miRNA transcription by RNA polymerase II 0061844:antimicrobial humoral immune response mediated by antimicrobial peptide 1990000:amyloid fibril formation 0045087:innate immune response 0006378:mRNA polyadenylation 0001878:response to yeast 0001664:G protein-coupled receptor binding 0007617:mating behavior 2000406:positive regulation of T cell migration 1904591:positive regulation of protein import 1905906:regulation of amyloid fibril formation 0001967:suckling behavior 0051124:synaptic growth at neuromuscular junction 0007613:memory 0042803:protein homodimerization activity 0106003:amyloid-beta complex 1900272:negative regulation of long-term synaptic potentiation 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0045429:positive regulation of nitric oxide biosynthetic process 0019732:antifungal humoral response 0045177:apical part of cell 0042157:lipoprotein metabolic process 0016199:axon midline choice point recognition 0000187:activation of MAPK activity 0071874:cellular response to norepinephrine stimulus 0005798:Golgi-associated vesicle 1900181:negative regulation of protein localization to nucleus 1904472:positive regulation of endothelin production 0050885:neuromuscular process controlling balance 0042327:positive regulation of phosphorylation 1904399:heparan sulfate binding 0008306:associative learning 0043198:dendritic shaft 0042056:chemoattractant activity 0051091:positive regulation of DNA-binding transcription factor activity 0070555:response to interleukin-1 1990535:neuron projection maintenance 0016322:neuron remodeling 0043410:positive regulation of MAPK cascade 0005796:Golgi lumen 0005641:nuclear envelope lumen 0050786:RAGE receptor binding 0051087:chaperone binding 0051233:spindle midzone 0007626:locomotory behavior 0032755:positive regulation of interleukin-6 production 0055037:recycling endosome 0090026:positive regulation of monocyte chemotaxis 0007409:axonogenesis 0046914:transition metal ion binding 1905898:positive regulation of response to endoplasmic reticulum stress 0001774:microglial cell activation 0032760:positive regulation of tumor necrosis factor production 0031594:neuromuscular junction 0005109:frizzled binding 0002576:platelet degranulation 0030111:regulation of Wnt signaling pathway 1900273:positive regulation of long-term synaptic potentiation 1905896:positive regulation of cellular response to tunicamycin 0042802:identical protein binding 1904022:positive regulation of G protein-coupled receptor internalization 0032729:positive regulation of interferon-gamma production 0009987:cellular process 0030900:forebrain development 0005790:smooth endoplasmic reticulum 0061098:positive regulation of protein tyrosine kinase activity 0019899:enzyme binding 0006878:cellular copper ion homeostasis 0046330:positive regulation of JNK cascade 0030134:COPII-coated ER to Golgi transport vesicle 0048471:perinuclear region of cytoplasm 0030549:acetylcholine receptor activator activity 0035235:ionotropic glutamate receptor signaling pathway 0050729:positive regulation of inflammatory response 0031904:endosome lumen 0071287:cellular response to manganese ion 0004867:serine-type endopeptidase inhibitor activity 0007155:cell adhesion 0030424:axon 0051092:positive regulation of NF-kappaB transcription factor activity 0045821:positive regulation of glycolytic process 0000122:negative regulation of transcription by RNA polymerase II 0000185:activation of MAPKKK activity 0051897:positive regulation of protein kinase B signaling 0008542:visual learning 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0048143:astrocyte activation 1903223:positive regulation of oxidative stress-induced neuron death 0019731:antibacterial humoral response 0006357:regulation of transcription by RNA polymerase II 0010971:positive regulation of G2/M transition of mitotic cell cycle 1904646:cellular response to amyloid-beta 0050867:positive regulation of cell activation 0005791:rough endoplasmic reticulum 0032092:positive regulation of protein binding 0043197:dendritic spine 0016020:membrane 0090090:negative regulation of canonical Wnt signaling pathway 0090647:modulation of age-related behavioral decline 0033138:positive regulation of peptidyl-serine phosphorylation 0006892:post-Golgi vesicle-mediated transport 0050808:synapse organization 0048786:presynaptic active zone 0010468:regulation of gene expression 0001934:positive regulation of protein phosphorylation 0045931:positive regulation of mitotic cell cycle 0043065:positive regulation of apoptotic process 1990090:cellular response to nerve growth factor stimulus 0006417:regulation of translation 0045202:synapse 0032588:trans-Golgi network membrane 0005886:plasma membrane 0008203:cholesterol metabolic process 0043687:post-translational protein modification 0035590:purinergic nucleotide receptor signaling pathway 0043395:heparan sulfate proteoglycan binding 0005768:endosome 1902950:regulation of dendritic spine maintenance 1990812:growth cone filopodium 0031093:platelet alpha granule lumen 1901215:negative regulation of neuron death 1990777:lipoprotein particle 0003677:DNA binding 0034363:intermediate-density lipoprotein particle 0043525:positive regulation of neuron apoptotic process 0005739:mitochondrion 0045944:positive regulation of transcription by RNA polymerase II 0005634:nucleus 0008088:axo-dendritic transport 0050750:low-density lipoprotein particle receptor binding 1903048:regulation of acetylcholine-gated cation channel activity 0016504:peptidase activator activity 0010628:positive regulation of gene expression 0005769:early endosome 0005158:insulin receptor binding 0005788:endoplasmic reticulum lumen 0034121:regulation of toll-like receptor signaling pathway 0006979:response to oxidative stress 1990761:growth cone lamellipodium 0008201:heparin binding 0008285:negative regulation of cell population proliferation 0008021:synaptic vesicle 0007204:positive regulation of cytosolic calcium ion concentration 0051044:positive regulation of membrane protein ectodomain proteolysis 0010739:positive regulation of protein kinase A signaling 0070062:extracellular exosome 0071280:cellular response to copper ion 0048169:regulation of long-term neuronal synaptic plasticity 0005615:extracellular space 0046983:protein dimerization activity 1905908:positive regulation of amyloid fibril formation 1901224:positive regulation of NIK/NF-kappaB signaling 0006468:protein phosphorylation 2000310:regulation of NMDA receptor activity 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0050890:cognition 0051425:PTB domain binding 0008344:adult locomotory behavior 0010823:negative regulation of mitochondrion organization 1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1900122:positive regulation of receptor binding 1902949:positive regulation of tau-protein kinase activity 1905606:regulation of presynapse assembly 0005829:cytosol 0035253:ciliary rootlet 0031175:neuron projection development 0046982:protein heterodimerization activity 0050830:defense response to Gram-positive bacterium 0034185:apolipoprotein binding 0005794:Golgi apparatus 0006897:endocytosis 0005911:cell-cell junction 0043204:perikaryon 0051262:protein tetramerization 1901216:positive regulation of neuron death 0005887:integral component of plasma membrane 0007611:learning or memory 0005737:cytoplasm 0061903:positive regulation of 1-phosphatidylinositol-3-kinase activity 0070381:endosome to plasma membrane transport vesicle 0002265:astrocyte activation involved in immune response 0050829:defense response to Gram-negative bacterium 0043235:receptor complex 0032930:positive regulation of superoxide anion generation 0005905:clathrin-coated pit 0045121:membrane raft 0070374:positive regulation of ERK1 and ERK2 cascade 0030198:extracellular matrix organization 0051563:smooth endoplasmic reticulum calcium ion homeostasis 0033130:acetylcholine receptor binding 1903523:negative regulation of blood circulation 0050730:regulation of peptidyl-tyrosine phosphorylation 0070206:protein trimerization 0019722:calcium-mediated signaling 0045665:negative regulation of neuron differentiation 0097449:astrocyte projection 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0048669:collateral sprouting in absence of injury
PDB	2LMN ; 4M1C ; 2Y29 ; 1QXC ; 1IYT ; 6O4J ; 2FK2 ; 1TAW ; 3MOQ ; 2LOH ; 3OVJ ; 1HZ3 ; 6RHY ; 3MXY ; 1QWP ; 2LMQ ; 3MXC ; 4MDR ; 2LP1 ; 5C67 ; 3IFO ; 2MVX ; 5LFY ; 3AYU ; 2M4J ; 1TKN ; 3SV1 ; 3BAE ; 3IFN ; 1QYT ; 2Y3K ; 4PQD ; 6TI6 ; 3UMK ; 3L81 ; 4MVK ; 1ZE9 ; 3PZZ ; 5VZY ; 2BP4 ; 1BA6 ; 5OQV ; 5HOX ; 3UMH ; 5ONQ ; 2OTK ; 3DXC ; 2LZ4 ; 1CA0 ; 2FKL ; 4MVL ; 5AMB ; 3KTM ; 1BA4 ; 2LLM ; 2Y3J ; 1AML ; 1AMC ; 2LFM ; 3DXE ; 1UO7 ; 5LV0 ; 6TI7 ; 2M9R ; 7JXN ; 1AMB ; 2G47 ; 3NYJ ; 4MVI ; 2FMA ; 6OC9 ; 4HIX ; 2IPU ; 3L33 ; 3IFL ; 3Q2X ; 5HOY ; 6SZF ; 2MGT ; 2MPZ ; 5HOW ; 3BKJ ; 5ONP ; 1X11 ; 4PWQ ; 1ZE7 ; 2MXU ; 1ZJD ; 3OW9 ; 2FJZ ; 4ONF ; 6W0O ; 6YHF ; 1UOA ; 6GFI ; 1Z0Q ; 1AAP ; 5BUO ; 5MY4 ; 7B3K ; 7JXO ; 6YHX ; 5TXD ; 6YHI ; 6YHO ; 2LMO ; 5AM8 ; 6ITU ; 5MYO ; 2FK3 ; 4OJF ; 5W3P ; 3U0T ; 2LNQ ; 3DXD ; 3JQ5 ; 2LMP ; 3NYL ; 2LZ3 ; 1BJB ; 1BRC ; 3JTI ; 5AEF ; 1UOI ; 4ONG ; 4JFN ; 1BJC ; 4NGE ; 2MJ1 ; 2Y2A ; 2R0W ; 1OWT ; 2NAO ; 6NB9 ; 6CO3 ; 2Y3L ; 6TI5 ; 3JQL ; 3UMI ; 2WK3 ; 5KK3 ; 5CSZ ; 6OIZ ; 7B3J ; 1QCM ; 6IYC ; 2BOM ; 6WXM ; 1UO8 ; 2BEG ; 5VOS ; 2FK1 ; 3GCI ; 4XXD ; 6SHS ; 3IFP ; 1MWP ; 6YHP ; 2M9S ; 5MYX
Drugbank	DB02709 ; DB03754 ; DB14533 ; DB01370 ; DB06782 ; DB09149 ; DB02235 ; DB14517 ; DB14518 ; DB00746 ; DB05938 ; DB04892 ; DB09130 ; DB09148 ; DB09151 ; DB01593 ; DB05088 ; DB05846 ; DB05150 ; DB14548 ; DB14487
KEGG	hsa:351

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Name: Icariin

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Name: Osthole

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Name: Paeoniflorin

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Name: Cholesterol

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Name: (+/-)Nicotine

< 1 2 3 >

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H1162	Hang Shao	杭芍	White peony root	Paeonia albiflora
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0430	She Chuang Zi	蛇床子	Common cnidium	Cnidium monnieri
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H1036	Fen Dan Pi	粉丹皮	Tree peony bark	Paeonia suffruticosa
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1009	Du Huo	独活	Doubleteeth pubescent angelica	Angelica pubescens
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0901	Chun Gen Teng	春根藤	Twig and leaf of creeping psychotria	Psychotria serpens
H0868	Chuan Du Huo	川独活	Doubleteeth pubescent angelica	Angelica pubescens
H1175	Hei Dou	黑豆	Black bean	Semen glycine max
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0021	Bai Shao	白芍	Common peony	Paeonia lactiflora
H0752	Yin Yang Huo Gan Gao Fen	淫羊藿干膏粉	Epimedium sagittatum	Epimedium brevicornum
H0751	Yin Yang Huo	淫羊藿	NA	Epimedium brevicornum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0433	She Ma Zi	蛇麻子	Common cnidium fruit	Cnidium monnieri
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H0331	Qiang Huo	羌活	Incised notopterygium	Notopterygium incisum
H0404	Shan Ci Gu	山慈菇	Arrowhead-like wildginger	Asarum sagittarioides
H0753	Yin Yang Huo Jin Gao	淫羊藿浸膏	Epimedium sagittatum	Epimedium brevicornum
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0635	Xian He Cao Jin Gao Fen	仙鹤草浸膏粉	Japanese argimonia	Agrimonia pilosa var. japonica
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0218	Man Jiu Jie	蔓九节	Creeping ninenode	Psychotria serpens
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0922	Da Du Huo	大独活	root of laxflower cowparsnip	Radix heraclei maximi
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0634	Xian He Cao	仙鹤草	Japanese argimonia	Agrimonia pilosa var. japonica
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0023	Bai Shao Gan Jin Gao	白芍干浸膏	Common peony	Paeonia lactiflora
H0542	Tian Ma	天麻	Tall gastrodia	Gastrodia elata
H0881	Chuan Qiang Huo	川羌活	Incised notopterygium	Notopterygium incisum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0416	Shan Shen	山参	NA	Panax ginseng
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis

Target Description

Related Compounds (Total: 15)

Related Herbs (Total: 80)