Target Description

Type Detail
Target ID T01E8J
Protein Name Amyloid-beta precursor protein
Uniprot ID P05067
Protein Name Alias APP;  ABPP;  APPI;  Alzheimer disease amyloid protein;  Amyloid precursor protein;  Amyloid-beta A4 protein;  Cerebral vascular amyloid peptide;  CVAP;  PreA4;  Protease nexin-II;  PN-II
Gene ID 351
Gene Symbol APP
Gene Alias A4;  AD1
TTD T87024: Successful target
Pfam PF10515 ; PF12925 ; PF02177 ; PF12924 ; PF03494 ; PF00014
0005178:integrin binding

0070851:growth factor receptor binding

0032731:positive regulation of interleukin-1 beta production

0045048:protein insertion into ER membrane

0032991:protein-containing complex

0010629:negative regulation of gene expression

0007176:regulation of epidermal growth factor-activated receptor activity

0009986:cell surface

0016021:integral component of membrane

0016358:dendrite development

0045666:positive regulation of neuron differentiation

0030546:signaling receptor activator activity

0032722:positive regulation of chemokine production

0050803:regulation of synapse structure or activity

0044267:cellular protein metabolic process

1900221:regulation of amyloid-beta clearance

0097645:amylin binding

0014005:microglia development

0051402:neuron apoptotic process

0051247:positive regulation of protein metabolic process

1905893:positive regulation of cellular response to thapsigargin

0007186:G protein-coupled receptor signaling pathway

0003682:chromatin binding


2000463:positive regulation of excitatory postsynaptic potential

0034364:high-density lipoprotein particle

0005102:signaling receptor binding

1905945:regulation of response to calcium ion

0040014:regulation of multicellular organism growth

0098815:modulation of excitatory postsynaptic potential

0150003:regulation of spontaneous synaptic transmission

0035066:positive regulation of histone acetylation

0045745:positive regulation of G protein-coupled receptor signaling pathway

0010800:positive regulation of peptidyl-threonine phosphorylation

0005576:extracellular region

0007219:Notch signaling pathway

0051260:protein homooligomerization

0046875:ephrin receptor binding

0010288:response to lead ion

0071320:cellular response to cAMP

0044304:main axon

1902894:negative regulation of pri-miRNA transcription by RNA polymerase II

0061844:antimicrobial humoral immune response mediated by antimicrobial peptide

1990000:amyloid fibril formation

0045087:innate immune response

0006378:mRNA polyadenylation

0001878:response to yeast

0001664:G protein-coupled receptor binding

0007617:mating behavior

2000406:positive regulation of T cell migration

1904591:positive regulation of protein import

1905906:regulation of amyloid fibril formation

0001967:suckling behavior

0051124:synaptic growth at neuromuscular junction


0042803:protein homodimerization activity

0106003:amyloid-beta complex

1900272:negative regulation of long-term synaptic potentiation

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0045429:positive regulation of nitric oxide biosynthetic process

0019732:antifungal humoral response

0045177:apical part of cell

0042157:lipoprotein metabolic process

0016199:axon midline choice point recognition

0000187:activation of MAPK activity

0071874:cellular response to norepinephrine stimulus

0005798:Golgi-associated vesicle

1900181:negative regulation of protein localization to nucleus

1904472:positive regulation of endothelin production

0050885:neuromuscular process controlling balance

0042327:positive regulation of phosphorylation

1904399:heparan sulfate binding

0008306:associative learning

0043198:dendritic shaft

0042056:chemoattractant activity

0051091:positive regulation of DNA-binding transcription factor activity

0070555:response to interleukin-1

1990535:neuron projection maintenance

0016322:neuron remodeling

0043410:positive regulation of MAPK cascade

0005796:Golgi lumen

0005641:nuclear envelope lumen

0050786:RAGE receptor binding

0051087:chaperone binding

0051233:spindle midzone

0007626:locomotory behavior

0032755:positive regulation of interleukin-6 production

0055037:recycling endosome

0090026:positive regulation of monocyte chemotaxis


0046914:transition metal ion binding

1905898:positive regulation of response to endoplasmic reticulum stress

0001774:microglial cell activation

0032760:positive regulation of tumor necrosis factor production

0031594:neuromuscular junction

0005109:frizzled binding

0002576:platelet degranulation

0030111:regulation of Wnt signaling pathway

1900273:positive regulation of long-term synaptic potentiation

1905896:positive regulation of cellular response to tunicamycin

0042802:identical protein binding

1904022:positive regulation of G protein-coupled receptor internalization

0032729:positive regulation of interferon-gamma production

0009987:cellular process

0030900:forebrain development

0005790:smooth endoplasmic reticulum

0061098:positive regulation of protein tyrosine kinase activity

0019899:enzyme binding

0006878:cellular copper ion homeostasis

0046330:positive regulation of JNK cascade

0030134:COPII-coated ER to Golgi transport vesicle

0048471:perinuclear region of cytoplasm

0030549:acetylcholine receptor activator activity

0035235:ionotropic glutamate receptor signaling pathway

0050729:positive regulation of inflammatory response

0031904:endosome lumen

0071287:cellular response to manganese ion

0004867:serine-type endopeptidase inhibitor activity

0007155:cell adhesion


0051092:positive regulation of NF-kappaB transcription factor activity

0045821:positive regulation of glycolytic process

0000122:negative regulation of transcription by RNA polymerase II

0000185:activation of MAPKKK activity

0051897:positive regulation of protein kinase B signaling

0008542:visual learning

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0048143:astrocyte activation

1903223:positive regulation of oxidative stress-induced neuron death

0019731:antibacterial humoral response

0006357:regulation of transcription by RNA polymerase II

0010971:positive regulation of G2/M transition of mitotic cell cycle

1904646:cellular response to amyloid-beta

0050867:positive regulation of cell activation

0005791:rough endoplasmic reticulum

0032092:positive regulation of protein binding

0043197:dendritic spine


0090090:negative regulation of canonical Wnt signaling pathway

0090647:modulation of age-related behavioral decline

0033138:positive regulation of peptidyl-serine phosphorylation

0006892:post-Golgi vesicle-mediated transport

0050808:synapse organization

0048786:presynaptic active zone

0010468:regulation of gene expression

0001934:positive regulation of protein phosphorylation

0045931:positive regulation of mitotic cell cycle

0043065:positive regulation of apoptotic process

1990090:cellular response to nerve growth factor stimulus

0006417:regulation of translation


0032588:trans-Golgi network membrane

0005886:plasma membrane

0008203:cholesterol metabolic process

0043687:post-translational protein modification

0035590:purinergic nucleotide receptor signaling pathway

0043395:heparan sulfate proteoglycan binding


1902950:regulation of dendritic spine maintenance

1990812:growth cone filopodium

0031093:platelet alpha granule lumen

1901215:negative regulation of neuron death

1990777:lipoprotein particle

0003677:DNA binding

0034363:intermediate-density lipoprotein particle

0043525:positive regulation of neuron apoptotic process


0045944:positive regulation of transcription by RNA polymerase II


0008088:axo-dendritic transport

0050750:low-density lipoprotein particle receptor binding

1903048:regulation of acetylcholine-gated cation channel activity

0016504:peptidase activator activity

0010628:positive regulation of gene expression

0005769:early endosome

0005158:insulin receptor binding

0005788:endoplasmic reticulum lumen

0034121:regulation of toll-like receptor signaling pathway

0006979:response to oxidative stress

1990761:growth cone lamellipodium

0008201:heparin binding

0008285:negative regulation of cell population proliferation

0008021:synaptic vesicle

0007204:positive regulation of cytosolic calcium ion concentration

0051044:positive regulation of membrane protein ectodomain proteolysis

0010739:positive regulation of protein kinase A signaling

0070062:extracellular exosome

0071280:cellular response to copper ion

0048169:regulation of long-term neuronal synaptic plasticity

0005615:extracellular space

0046983:protein dimerization activity

1905908:positive regulation of amyloid fibril formation

1901224:positive regulation of NIK/NF-kappaB signaling

0006468:protein phosphorylation

2000310:regulation of NMDA receptor activity

0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway


0051425:PTB domain binding

0008344:adult locomotory behavior

0010823:negative regulation of mitochondrion organization

1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

1900122:positive regulation of receptor binding

1902949:positive regulation of tau-protein kinase activity

1905606:regulation of presynapse assembly


0035253:ciliary rootlet

0031175:neuron projection development

0046982:protein heterodimerization activity

0050830:defense response to Gram-positive bacterium

0034185:apolipoprotein binding

0005794:Golgi apparatus


0005911:cell-cell junction


0051262:protein tetramerization

1901216:positive regulation of neuron death

0005887:integral component of plasma membrane

0007611:learning or memory


0061903:positive regulation of 1-phosphatidylinositol-3-kinase activity

0070381:endosome to plasma membrane transport vesicle

0002265:astrocyte activation involved in immune response

0050829:defense response to Gram-negative bacterium

0043235:receptor complex

0032930:positive regulation of superoxide anion generation

0005905:clathrin-coated pit

0045121:membrane raft

0070374:positive regulation of ERK1 and ERK2 cascade

0030198:extracellular matrix organization

0051563:smooth endoplasmic reticulum calcium ion homeostasis

0033130:acetylcholine receptor binding

1903523:negative regulation of blood circulation

0050730:regulation of peptidyl-tyrosine phosphorylation

0070206:protein trimerization

0019722:calcium-mediated signaling

0045665:negative regulation of neuron differentiation

0097449:astrocyte projection

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0048669:collateral sprouting in absence of injury

PDB 2LMN ; 4M1C ; 2Y29 ; 1QXC ; 1IYT ; 6O4J ; 2FK2 ; 1TAW ; 3MOQ ; 2LOH ; 3OVJ ; 1HZ3 ; 6RHY ; 3MXY ; 1QWP ; 2LMQ ; 3MXC ; 4MDR ; 2LP1 ; 5C67 ; 3IFO ; 2MVX ; 5LFY ; 3AYU ; 2M4J ; 1TKN ; 3SV1 ; 3BAE ; 3IFN ; 1QYT ; 2Y3K ; 4PQD ; 6TI6 ; 3UMK ; 3L81 ; 4MVK ; 1ZE9 ; 3PZZ ; 5VZY ; 2BP4 ; 1BA6 ; 5OQV ; 5HOX ; 3UMH ; 5ONQ ; 2OTK ; 3DXC ; 2LZ4 ; 1CA0 ; 2FKL ; 4MVL ; 5AMB ; 3KTM ; 1BA4 ; 2LLM ; 2Y3J ; 1AML ; 1AMC ; 2LFM ; 3DXE ; 1UO7 ; 5LV0 ; 6TI7 ; 2M9R ; 7JXN ; 1AMB ; 2G47 ; 3NYJ ; 4MVI ; 2FMA ; 6OC9 ; 4HIX ; 2IPU ; 3L33 ; 3IFL ; 3Q2X ; 5HOY ; 6SZF ; 2MGT ; 2MPZ ; 5HOW ; 3BKJ ; 5ONP ; 1X11 ; 4PWQ ; 1ZE7 ; 2MXU ; 1ZJD ; 3OW9 ; 2FJZ ; 4ONF ; 6W0O ; 6YHF ; 1UOA ; 6GFI ; 1Z0Q ; 1AAP ; 5BUO ; 5MY4 ; 7B3K ; 7JXO ; 6YHX ; 5TXD ; 6YHI ; 6YHO ; 2LMO ; 5AM8 ; 6ITU ; 5MYO ; 2FK3 ; 4OJF ; 5W3P ; 3U0T ; 2LNQ ; 3DXD ; 3JQ5 ; 2LMP ; 3NYL ; 2LZ3 ; 1BJB ; 1BRC ; 3JTI ; 5AEF ; 1UOI ; 4ONG ; 4JFN ; 1BJC ; 4NGE ; 2MJ1 ; 2Y2A ; 2R0W ; 1OWT ; 2NAO ; 6NB9 ; 6CO3 ; 2Y3L ; 6TI5 ; 3JQL ; 3UMI ; 2WK3 ; 5KK3 ; 5CSZ ; 6OIZ ; 7B3J ; 1QCM ; 6IYC ; 2BOM ; 6WXM ; 1UO8 ; 2BEG ; 5VOS ; 2FK1 ; 3GCI ; 4XXD ; 6SHS ; 3IFP ; 1MWP ; 6YHP ; 2M9S ; 5MYX
Drugbank DB02709 ; DB03754 ; DB14533 ; DB01370 ; DB06782 ; DB09149 ; DB02235 ; DB14517 ; DB14518 ; DB00746 ; DB05938 ; DB04892 ; DB09130 ; DB09148 ; DB09151 ; DB01593 ; DB05088 ; DB05846 ; DB05150 ; DB14548 ; DB14487
KEGG hsa:351

Related Compounds  (Total: 15)

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Name: Icariin
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Name: Osthole
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Name: Paeoniflorin
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Name: Cholesterol
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Name: (+/-)Nicotine

Related Herbs  (Total: 80)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H1162 Hang Shao杭芍 White peony rootPaeonia albiflora
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0802 Zhi Geng枳梗 NACitrus aurantium
H0357 Ren Shen人参 GinsengPanax ginseng
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0430 She Chuang Zi蛇床子 Common cnidiumCnidium monnieri
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H1175 Hei Dou黑豆 Black beanSemen glycine max
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0021 Bai Shao白芍 Common peonyPaeonia lactiflora
H0752 Yin Yang Huo Gan Gao Fen淫羊藿干膏粉 Epimedium sagittatumEpimedium brevicornum
H0751 Yin Yang Huo淫羊藿 NAEpimedium brevicornum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0433 She Ma Zi蛇麻子 Common cnidium fruitCnidium monnieri
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0331 Qiang Huo羌活 Incised notopterygiumNotopterygium incisum
H0404 Shan Ci Gu山慈菇 Arrowhead-like wildgingerAsarum sagittarioides
H0753 Yin Yang Huo Jin Gao淫羊藿浸膏 Epimedium sagittatumEpimedium brevicornum
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0635 Xian He Cao Jin Gao Fen仙鹤草浸膏粉 Japanese argimoniaAgrimonia pilosa var. japonica
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0922 Da Du Huo大独活 root of laxflower cowparsnipRadix heraclei maximi
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora
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H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0634 Xian He Cao仙鹤草 Japanese argimoniaAgrimonia pilosa var. japonica
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
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H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0023 Bai Shao Gan Jin Gao白芍干浸膏 Common peonyPaeonia lactiflora
H0542 Tian Ma天麻 Tall gastrodiaGastrodia elata
H0881 Chuan Qiang Huo川羌活 Incised notopterygiumNotopterygium incisum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0476 Can E蚕蛾 SilkwormBombyx mori
H0416 Shan Shen山参 NAPanax ginseng
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis