HIT-result

ID: C0271	Common name: Osthole
IUPAC: 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one	CAS: CAS:484-12-8
Chembl ID: CHEMBL52229	Pubchem ID: CID:10228
Formula: C15H16O3	TCM-ID: TCMC1803
Smiles: CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
Alias: 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-; Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-; Osthole; 7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one; 7-Methoxy-8-(3-methyl-2-butenyl)coumarin; 7-Methoxy-8-isopentenylcoumarin; 8-(3-Methyl-2-butenyl)herniarin; NSC 31868; Osthol; Ostol; Ostole	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T98RXH	Focal adhesion kinase 1	PTK2	Q05397	A	1 Reference(s)
T74JJN	Fatty acid synthase	FASN	P49327	A	1 Reference(s)
T31SX8	Bone morphogenetic protein 2	BMP2	P12643	B	1 Reference(s)
T36NQ9	Mothers against decapentaplegic homolog 1	SMAD1	Q15797	B	1 Reference(s)
T85U8U	Caspase-3	CASP3	P42574	B	1 Reference(s)
T21Q0D	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	P04035	C	1 Reference(s)
T42EAZ	Vascular endothelial growth factor A	VEGFA	P15692	C	1 Reference(s)
T06RMZ	Nuclear factor NF-kappa-B p105 subunit	NFKB1	P19838	C	1 Reference(s)
T50WOV	ATP-dependent translocase ABCB1	ABCB1	P08183	C	1 Reference(s)
T88P76	DNA excision repair protein ERCC-1	ERCC1	P07992	C	1 Reference(s)
T77OVM	Diablo homolog, mitochondrial	DIABLO	Q9NR28	C	1 Reference(s)
T36SCD	NA	MIR107	NA	C	1 Reference(s)
T20IHC	Diacylglycerol O-acyltransferase 1	DGAT1	O75907	C	1 Reference(s)
T10HL8	Intercellular adhesion molecule 1	ICAM1	P05362	C	1 Reference(s)
T79KQO	NF-kappa-B inhibitor alpha	NFKBIA	P25963	C	1 Reference(s)
T92BZ2	Catenin beta-1	CTNNB1	P35222	C	1 Reference(s)
T59IKQ	Vascular cell adhesion protein 1	VCAM1	P19320	C	1 Reference(s)
T08Q7W	Prostaglandin G/H synthase 2	PTGS2	P35354	C	2 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	C	2 Reference(s)
T01E8J	Amyloid-beta precursor protein	APP	P05067	C	1 Reference(s)
T30VNV	Myeloperoxidase	MPO	P05164	C	1 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	C	1 Reference(s)
T33OPP	Interleukin-6	IL6	P05231	C	1 Reference(s)
T04H8Y	Beta-secretase 1	BACE1	P56817	C	1 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0331	Qiang Huo	羌活	Incised notopterygium	Notopterygium incisum
H0881	Chuan Qiang Huo	川羌活	Incised notopterygium	Notopterygium incisum
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H1009	Du Huo	独活	Doubleteeth pubescent angelica	Angelica pubescens
H0868	Chuan Du Huo	川独活	Doubleteeth pubescent angelica	Angelica pubescens
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0433	She Ma Zi	蛇麻子	Common cnidium fruit	Cnidium monnieri
H0634	Xian He Cao	仙鹤草	Japanese argimonia	Agrimonia pilosa var. japonica
H0430	She Chuang Zi	蛇床子	Common cnidium	Cnidium monnieri
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H0635	Xian He Cao Jin Gao Fen	仙鹤草浸膏粉	Japanese argimonia	Agrimonia pilosa var. japonica
H0922	Da Du Huo	大独活	root of laxflower cowparsnip	Radix heraclei maximi

Compound Description

Related Targets (Total: 25)

Related Herbs (Total: 18)