HIT-result

Target Description

Type	Detail
Target ID	T77OVM
Protein Name	Diablo homolog, mitochondrial
Uniprot ID	Q9NR28
Protein Name Alias	Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac
Gene ID	56616
Gene Symbol	DIABLO
Gene Alias	SMAC
TTD	T78150: Research target
Pfam	PF09057
GO	0005739:mitochondrion 0006915:apoptotic process 0008625:extrinsic apoptotic signaling pathway via death domain receptors 0097193:intrinsic apoptotic signaling pathway 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0005758:mitochondrial intermembrane space 0009898:cytoplasmic side of plasma membrane 0008635:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 0005829:cytosol 0008631:intrinsic apoptotic signaling pathway in response to oxidative stress 0035631:CD40 receptor complex 0043065:positive regulation of apoptotic process 0051402:neuron apoptotic process
PDB	3D9U ; 4TX5 ; 6JX6 ; 1G73 ; 1OXQ ; 1XB1 ; 1FEW ; 1TW6 ; 3UIH ; 1XB0 ; 1G3F ; 3UIJ
Drugbank	DB12695
KEGG	hsa:56616

Type

Detail

Target ID

T77OVM

Protein Name

Diablo homolog, mitochondrial

Uniprot ID

Q9NR28

Protein Name Alias

Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac

Gene ID

56616

Gene Symbol

DIABLO

Gene Alias

SMAC

TTD

T78150: Research target

Pfam

PF09057

0005739:mitochondrion

0006915:apoptotic process

0008625:extrinsic apoptotic signaling pathway via death domain receptors

0097193:intrinsic apoptotic signaling pathway

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0005758:mitochondrial intermembrane space

0009898:cytoplasmic side of plasma membrane

0008635:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

0005829:cytosol

0008631:intrinsic apoptotic signaling pathway in response to oxidative stress

0035631:CD40 receptor complex

0043065:positive regulation of apoptotic process

0051402:neuron apoptotic process

PDB

3D9U ; 4TX5 ; 6JX6 ; 1G73 ; 1OXQ ; 1XB1 ; 1FEW ; 1TW6 ; 3UIH ; 1XB0 ; 1G3F ; 3UIJ

Drugbank

DB12695

KEGG

hsa:56616

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0331	Qiang Huo	羌活	Incised notopterygium	Notopterygium incisum
H0881	Chuan Qiang Huo	川羌活	Incised notopterygium	Notopterygium incisum
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H1009	Du Huo	独活	Doubleteeth pubescent angelica	Angelica pubescens
H0868	Chuan Du Huo	川独活	Doubleteeth pubescent angelica	Angelica pubescens
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0433	She Ma Zi	蛇麻子	Common cnidium fruit	Cnidium monnieri
H0634	Xian He Cao	仙鹤草	Japanese argimonia	Agrimonia pilosa var. japonica
H0430	She Chuang Zi	蛇床子	Common cnidium	Cnidium monnieri
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H0635	Xian He Cao Jin Gao Fen	仙鹤草浸膏粉	Japanese argimonia	Agrimonia pilosa var. japonica
H0922	Da Du Huo	大独活	root of laxflower cowparsnip	Radix heraclei maximi

Target Description