Compound Description

ID:   C1115 Common name:   cocaine
IUPAC:  methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate CAS:  CAS:50-36-2
Chembl ID:   CHEMBL370805 Pubchem ID:   CID:446220
Formula:  C17H21NO4 TCM-ID:  TCMC7550
Smiles:  CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC
Alias:

methyl (2R,3S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Structure:

Related Targets  (Total: 64)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T45O3H Phospholipase A1 member APLA1A Q53H76
A 1 Reference(s)
T73WJH Calcium/calmodulin-dependent protein kinase kinase 2CAMKK2 Q96RR4
B 1 Reference(s)
T43DMF Kappa-type opioid receptorOPRK1 P41145
B 1 Reference(s)
T91QL8 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DNAPEPLD Q6IQ20
B 1 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
B 1 Reference(s)
T07S0E BDNF/NT-3 growth factors receptorNTRK2 Q16620
B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
B 2 Reference(s)
T38T1U Caspase-8CASP8 Q14790
B 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
B 2 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
B 4 Reference(s)
T02DYS Protein fosBFOSB P53539
B 2 Reference(s)
T93VFT Endothelin-1EDN1 P05305
B 1 Reference(s)
T70U24 Sigma non-opioid intracellular receptor 1SIGMAR1 Q99720
B 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
B 2 Reference(s)
T18BSV Proenkephalin-BPDYN P01213
B 1 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
B 1 Reference(s)
T00EP2 Tissue-type plasminogen activatorPLAT P00750
B 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
B 1 Reference(s)
T49UAP Ras-specific guanine nucleotide-releasing factor 1RASGRF1 Q13972
B 1 Reference(s)
T47G3X Glucocorticoid receptorNR3C1 P04150
B 1 Reference(s)
T24LWC Sodium-dependent dopamine transporterSLC6A3 Q01959
B 3 Reference(s)
T06MQM Heat shock protein beta-1HSPB1 P04792
B 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
B 1 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
B 2 Reference(s)
T90SGJ Caspase-2CASP2 P42575
B 1 Reference(s)
T57GP2 ETS domain-containing protein Elk-1ELK1 P19419
B 1 Reference(s)
T43G0N Cytochrome P450 2C8CYP2C8 P10632
B 1 Reference(s)
T69RXK Cytochrome P450 2C9CYP2C9 P11712
B 1 Reference(s)
T10GDC Gap junction delta-2 proteinGJD2 Q9UKL4
B 1 Reference(s)
T77FOL NeuromodulinGAP43 P17677
B 1 Reference(s)
T51WML Glutamate receptor 1GRIA1 P42261
B 1 Reference(s)
T05WWN CorticoliberinCRH P06850
B 1 Reference(s)
T66NVP Fatty-acid amide hydrolase 1FAAH O00519
B 1 Reference(s)
T20VPX Cyclin-dependent-like kinase 5CDK5 Q00535
B 2 Reference(s)
T36RGT Protein phosphatase 1 regulatory subunit 1BPPP1R1B Q9UD71
B 1 Reference(s)
T87WH7 Fos-related antigen 2FOSL2 P15408
B 2 Reference(s)
T86CQC Glutamate receptor ionotropic, NMDA 1GRIN1 Q05586
B 2 Reference(s)
T79MVU Nucleus accumbens-associated protein 1NACC1 Q96RE7
B 1 Reference(s)
T14JBS Glutamate receptor 2GRIA2 P42262
B 1 Reference(s)
T28IL8 D(1A) dopamine receptorDRD1 P21728
B 2 Reference(s)
T78QVQ Myosin-7MYH7 P12883
B 1 Reference(s)
T67HXL Glial cell line-derived neurotrophic factorGDNF P39905
B 1 Reference(s)
T48ZIG D(2) dopamine receptorDRD2 P14416
B 2 Reference(s)
T43Y5O D(3) dopamine receptorDRD3 P35462
C 1 Reference(s)
T02OOS C-C chemokine receptor type 5CCR5 P51681
C 1 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
C 1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
C 1 Reference(s)
T77RFX Alpha-2A adrenergic receptorADRA2A P08913
C 1 Reference(s)
T52XO3 Cytochrome P450 2J2CYP2J2 P51589
C 1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
C 1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
C 1 Reference(s)
T55K2O Regulator of G-protein signaling 9RGS9 O75916
C 1 Reference(s)
T70TT3 Regulator of G-protein signaling 17RGS17 Q9UGC6
C 1 Reference(s)
T62DHC Uroplakin-3bUPK3B Q9BT76
C 1 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
C 1 Reference(s)
T40TU6 Tissue factor pathway inhibitor 2TFPI2 P48307
C 1 Reference(s)
T33S3M Regulator of G-protein signaling 2RGS2 P41220
C 1 Reference(s)
T66A7X Activity-regulated cytoskeleton-associated proteinARC Q7LC44
C 1 Reference(s)
T03VS9 Protein-tyrosine kinase 2-betaPTK2B Q14289
C 1 Reference(s)
T53GDC Tyrosine-protein kinase LckLCK P06239
C 1 Reference(s)
T09X0D Neurexin-3-betaNRXN3 Q9HDB5
C 1 Reference(s)
T73EVE Cyclic AMP-dependent transcription factor ATF-2ATF2 P15336
C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
C 1 Reference(s)
T45B9P ATP-sensitive inward rectifier potassium channel 11KCNJ11 Q14654
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 0)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name