HIT-result

Target Description

Type	Detail
Target ID	T45B9P
Protein Name	ATP-sensitive inward rectifier potassium channel 11
Uniprot ID	Q14654
Protein Name Alias	IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
Gene ID	3767
Gene Symbol	KCNJ11
Gene Alias	NA
TTD	T00820: Research target
Pfam	PF17655 ; PF01007
GO	0033574:response to testosterone 0005768:endosome 0055085:transmembrane transport 0050877:nervous system process 0030506:ankyrin binding 0050796:regulation of insulin secretion 0005829:cytosol 0071316:cellular response to nicotine 0042391:regulation of membrane potential 0008022:protein C-terminus binding 0070852:cell body fiber 0034765:regulation of ion transmembrane transport 0006006:glucose metabolic process 0071805:potassium ion transmembrane transport 0044325:ion channel binding 0005783:endoplasmic reticulum 0014704:intercalated disc 0005524:ATP binding 0015272:ATP-activated inward rectifier potassium channel activity 0008282:inward rectifying potassium channel 0031072:heat shock protein binding 0002931:response to ischemia 0030955:potassium ion binding 0005635:nuclear envelope 0071333:cellular response to glucose stimulus 0071356:cellular response to tumor necrosis factor 0046676:negative regulation of insulin secretion 0005242:inward rectifier potassium channel activity 0030673:axolemma 0001669:acrosomal vesicle 0030315:T-tubule 0043025:neuronal cell body 0005886:plasma membrane 1990573:potassium ion import across plasma membrane 1903779:regulation of cardiac conduction 0033198:response to ATP 0005249:voltage-gated potassium channel activity 0005887:integral component of plasma membrane 0042493:response to drug 0019829:ATPase-coupled cation transmembrane transporter activity 0098662:inorganic cation transmembrane transport 1903078:positive regulation of protein localization to plasma membrane 2001259:positive regulation of cation channel activity 0032355:response to estradiol 0043209:myelin sheath 0005739:mitochondrion
PDB	6C3P ; 6C3O
Drugbank	DB01119 ; DB00839 ; DB00222 ; DB01154 ; DB00661 ; DB11148 ; DB00308 ; DB00922 ; DB01016 ; DB11633 ; DB01392
KEGG	hsa:3767

Type

Detail

Target ID

T45B9P

Protein Name

ATP-sensitive inward rectifier potassium channel 11

Uniprot ID

Q14654

Protein Name Alias

IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11

Gene ID

3767

Gene Symbol

KCNJ11

Gene Alias

TTD

T00820: Research target

Pfam

PF17655 ; PF01007

0033574:response to testosterone

0005768:endosome

0055085:transmembrane transport

0050877:nervous system process

0030506:ankyrin binding

0050796:regulation of insulin secretion

0005829:cytosol

0071316:cellular response to nicotine

0042391:regulation of membrane potential

0008022:protein C-terminus binding

0070852:cell body fiber

0034765:regulation of ion transmembrane transport

0006006:glucose metabolic process

0071805:potassium ion transmembrane transport

0044325:ion channel binding

0005783:endoplasmic reticulum

0014704:intercalated disc

0005524:ATP binding

0015272:ATP-activated inward rectifier potassium channel activity

0008282:inward rectifying potassium channel

0031072:heat shock protein binding

0002931:response to ischemia

0030955:potassium ion binding

0005635:nuclear envelope

0071333:cellular response to glucose stimulus

0071356:cellular response to tumor necrosis factor

0046676:negative regulation of insulin secretion

0005242:inward rectifier potassium channel activity

0030673:axolemma

0001669:acrosomal vesicle

0030315:T-tubule

0043025:neuronal cell body

0005886:plasma membrane

1990573:potassium ion import across plasma membrane

1903779:regulation of cardiac conduction

0033198:response to ATP

0005249:voltage-gated potassium channel activity

0005887:integral component of plasma membrane

0042493:response to drug

0019829:ATPase-coupled cation transmembrane transporter activity

0098662:inorganic cation transmembrane transport

1903078:positive regulation of protein localization to plasma membrane

2001259:positive regulation of cation channel activity

0032355:response to estradiol

0043209:myelin sheath

0005739:mitochondrion

PDB

6C3P ; 6C3O

Drugbank

DB01119 ; DB00839 ; DB00222 ; DB01154 ; DB00661 ; DB11148 ; DB00308 ; DB00922 ; DB01016 ; DB11633 ; DB01392

KEGG

hsa:3767

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0087	Ju Gu Ye	枸骨叶	FOLIUM iLICIS cORNUTAE	Ilex cornuta
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H0233	Mao Liang Mian Zhen	毛两面针	NA	Zanthoxylum nitidum
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H1214	Hua Jiao	花椒	Bunge pricklyash	Zanthoxylum bungeanum
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H1163	He Bao Cao	荷包草	NA	Lamprocapnos spectabilis
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 19)