HIT-result

Type	Detail
Target ID	T53GDC
Protein Name	Tyrosine-protein kinase Lck
Uniprot ID	P06239
Protein Name Alias	EC 2.7.10.2; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
Gene ID	3932
Gene Symbol	LCK
Gene Alias	NA
TTD	T12499: Successful target
Pfam	PF00018 ; PF07714 ; PF00017
GO	0005829:cytosol 0019221:cytokine-mediated signaling pathway 0051209:release of sequestered calcium ion into cytosol 0050852:T cell receptor signaling pathway 0008022:protein C-terminus binding 0018108:peptidyl-tyrosine phosphorylation 0031295:T cell costimulation 0004722:protein serine/threonine phosphatase activity 2001244:positive regulation of intrinsic apoptotic signaling pathway 0006882:cellular zinc ion homeostasis 0050862:positive regulation of T cell receptor signaling pathway 0043548:phosphatidylinositol 3-kinase binding 0042802:identical protein binding 0030154:cell differentiation 0050690:regulation of defense response to virus by virus 0001784:phosphotyrosine residue binding 0050900:leukocyte migration 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0004713:protein tyrosine kinase activity 0004715:non-membrane spanning protein tyrosine kinase activity 0001772:immunological synapse 0006468:protein phosphorylation 0070062:extracellular exosome 0004714:transmembrane receptor protein tyrosine kinase activity 0005524:ATP binding 0030217:T cell differentiation 0045121:membrane raft 0042610:CD8 receptor binding 0019903:protein phosphatase binding 0051117:ATPase binding 0030168:platelet activation 0031234:extrinsic component of cytoplasmic side of plasma membrane 0050853:B cell receptor signaling pathway 0050870:positive regulation of T cell activation 0005102:signaling receptor binding 0045087:innate immune response 0042609:CD4 receptor binding 1903039:positive regulation of leukocyte cell-cell adhesion 0051897:positive regulation of protein kinase B signaling 0042169:SH2 domain binding 0005886:plasma membrane 0051249:regulation of lymphocyte activation 0042608:T cell receptor binding 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0019901:protein kinase binding 0042493:response to drug 0000242:pericentriolar material 0034116:positive regulation of heterotypic cell-cell adhesion 0030097:hemopoiesis
PDB	3AD5 ; 1LCK ; 1X27 ; 5MTM ; 3BYO ; 4D8K ; 3BYM ; 1FBZ ; 2IIM ; 3MPM ; 1QPC ; 2OF4 ; 1CWE ; 1BHF ; 3ACK ; 3B2W ; 1Q68 ; 3AC4 ; 2ZM1 ; 2ZYB ; 3AC1 ; 2ZM4 ; 2OFU ; 3KMM ; 3BYS ; 1LKK ; 1LKL ; 5MTN ; 3AC5 ; 2PL0 ; 3BRH ; 1QPJ ; 1QPD ; 6H6A ; 3AD4 ; 3BYU ; 2OF2 ; 1LCJ ; 3AC8 ; 1Q69 ; 1CWD ; 2OG8 ; 4C3F ; 1IJR ; 3LCK ; 1QPE ; 3AC3 ; 1BHH ; 2OFV ; 3AD6 ; 1KIK ; 3KXZ ; 1H92 ; 6PDJ ; 3AC2 ; 3ACJ
Drugbank	DB04395 ; DB08901 ; DB02010 ; DB15035 ; DB04003 ; DB08057 ; DB08056 ; DB09079 ; DB01254 ; DB12010 ; DB03023 ; DB07146 ; DB06925 ; DB08055 ; DB07297 ; DB01830
KEGG	hsa:3932

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Name: Damnacanthal

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H1199	Hu Ci	虎刺	Indian damnacanthus	Damnacanthus indicus