HIT-result

Target Description

Type	Detail
Target ID	T77RFX
Protein Name	Alpha-2A adrenergic receptor
Uniprot ID	P08913
Protein Name Alias	Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR
Gene ID	150
Gene Symbol	ADRA2A
Gene Alias	ADRA2R; ADRAR
TTD	T11448: Successful target
Pfam	PF00001
GO	0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0016323:basolateral plasma membrane 0043406:positive regulation of MAP kinase activity 0032147:activation of protein kinase activity 0050796:regulation of insulin secretion 0045741:positive regulation of epidermal growth factor-activated receptor activity 0051044:positive regulation of membrane protein ectodomain proteolysis 0006940:regulation of smooth muscle contraction 0031692:alpha-1B adrenergic receptor binding 0042593:glucose homeostasis 0090303:positive regulation of wound healing 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0043268:positive regulation of potassium ion transport 0042803:protein homodimerization activity 0046982:protein heterodimerization activity 0019229:regulation of vasoconstriction 0004938:alpha2-adrenergic receptor activity 0032870:cellular response to hormone stimulus 0031996:thioesterase binding 0071882:phospholipase C-activating adrenergic receptor signaling pathway 0042596:fear response 0043410:positive regulation of MAPK cascade 0071881:adenylate cyclase-inhibiting adrenergic receptor signaling pathway 0045955:negative regulation of calcium ion-dependent exocytosis 0098691:dopaminergic synapse 0030036:actin cytoskeleton organization 0032795:heterotrimeric G-protein binding 0001819:positive regulation of cytokine production 0071875:adrenergic receptor signaling pathway 0051926:negative regulation of calcium ion transport 0010700:negative regulation of norepinephrine secretion 0050892:intestinal absorption 0030335:positive regulation of cell migration 2000300:regulation of synaptic vesicle exocytosis 0046676:negative regulation of insulin secretion 0030168:platelet activation 0043235:receptor complex 0004930:G protein-coupled receptor activity 0035624:receptor transactivation 0007265:Ras protein signal transduction 0050995:negative regulation of lipid catabolic process 0032811:negative regulation of epinephrine secretion 0051380:norepinephrine binding 0005886:plasma membrane 0007266:Rho protein signal transduction 0007186:G protein-coupled receptor signaling pathway 0005887:integral component of plasma membrane 0019901:protein kinase binding 0071880:adenylate cyclase-activating adrenergic receptor signaling pathway 0008284:positive regulation of cell population proliferation 1901020:negative regulation of calcium ion transmembrane transporter activity 0061179:negative regulation of insulin secretion involved in cellular response to glucose stimulus 0005737:cytoplasm 0032148:activation of protein kinase B activity 0031696:alpha-2C adrenergic receptor binding 0051379:epinephrine binding
PDB	6KUY ; 1HOF ; 6K42 ; 6KUX ; 1HLL ; 1HOD ; 1HO9
Drugbank	DB13345 ; DB01365 ; DB00925 ; DB09244 ; DB00852 ; DB06694 ; DB00449 ; DB11738 ; DB01175 ; DB00246 ; DB00182 ; DB00408 ; DB00457 ; DB14185 ; DB00714 ; DB08815 ; DB13025 ; DB09242 ; DB00797 ; DB00800 ; DB04948 ; DB00320 ; DB01149 ; DB00715 ; DB06707 ; DB01608 ; DB01224 ; DB05492 ; DB00540 ; DB00589 ; DB00321 ; DB00575 ; DB01238 ; DB09194 ; DB00726 ; DB00968 ; DB04855 ; DB01624 ; DB01472 ; DB00865 ; DB00692 ; DB00477 ; DB00484 ; DB11278 ; DB00413 ; DB00543 ; DB01200 ; DB00696 ; DB01151 ; DB01403 ; DB06229 ; DB00193 ; DB00935 ; DB06678 ; DB00633 ; DB11577 ; DB00629 ; DB06148 ; DB01392 ; DB00668 ; DB06711 ; DB01267 ; DB01186 ; DB00217 ; DB00268 ; DB06216 ; DB00697 ; DB01577 ; DB01576 ; DB11273 ; DB09202 ; DB04846 ; DB00368 ; DB09229 ; DB11124 ; DB00433 ; DB09195 ; DB09167 ; DB00502 ; DB00370 ; DB00248 ; DB00363 ; DB00656 ; DB09286 ; DB00397 ; DB06153 ; DB06623 ; DB00964 ; DB09205 ; DB11477 ; DB01018 ; DB00934 ; DB01136 ; DB00555 ; DB06262 ; DB01049 ; DB09304 ; DB01363 ; DB00751 ; DB01069
KEGG	hsa:150

Type

Detail

Target ID

T77RFX

Protein Name

Alpha-2A adrenergic receptor

Uniprot ID

P08913

Protein Name Alias

Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR

Gene ID

150

Gene Symbol

ADRA2A

Gene Alias

ADRA2R; ADRAR

TTD

T11448: Successful target

Pfam

PF00001

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0016323:basolateral plasma membrane

0043406:positive regulation of MAP kinase activity

0032147:activation of protein kinase activity

0050796:regulation of insulin secretion

0045741:positive regulation of epidermal growth factor-activated receptor activity

0051044:positive regulation of membrane protein ectodomain proteolysis

0006940:regulation of smooth muscle contraction

0031692:alpha-1B adrenergic receptor binding

0042593:glucose homeostasis

0090303:positive regulation of wound healing

0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

0043268:positive regulation of potassium ion transport

0042803:protein homodimerization activity

0046982:protein heterodimerization activity

0019229:regulation of vasoconstriction

0004938:alpha2-adrenergic receptor activity

0032870:cellular response to hormone stimulus

0031996:thioesterase binding

0071882:phospholipase C-activating adrenergic receptor signaling pathway

0042596:fear response

0043410:positive regulation of MAPK cascade

0071881:adenylate cyclase-inhibiting adrenergic receptor signaling pathway

0045955:negative regulation of calcium ion-dependent exocytosis

0098691:dopaminergic synapse

0030036:actin cytoskeleton organization

0032795:heterotrimeric G-protein binding

0001819:positive regulation of cytokine production

0071875:adrenergic receptor signaling pathway

0051926:negative regulation of calcium ion transport

0010700:negative regulation of norepinephrine secretion

0050892:intestinal absorption

0030335:positive regulation of cell migration

2000300:regulation of synaptic vesicle exocytosis

0046676:negative regulation of insulin secretion

0030168:platelet activation

0043235:receptor complex

0004930:G protein-coupled receptor activity

0035624:receptor transactivation

0007265:Ras protein signal transduction

0050995:negative regulation of lipid catabolic process

0032811:negative regulation of epinephrine secretion

0051380:norepinephrine binding

0005886:plasma membrane

0007266:Rho protein signal transduction

0007186:G protein-coupled receptor signaling pathway

0005887:integral component of plasma membrane

0019901:protein kinase binding

0071880:adenylate cyclase-activating adrenergic receptor signaling pathway

0008284:positive regulation of cell population proliferation

1901020:negative regulation of calcium ion transmembrane transporter activity

0061179:negative regulation of insulin secretion involved in cellular response to glucose stimulus

0005737:cytoplasm

0032148:activation of protein kinase B activity

0031696:alpha-2C adrenergic receptor binding

0051379:epinephrine binding

PDB

6KUY ; 1HOF ; 6K42 ; 6KUX ; 1HLL ; 1HOD ; 1HO9

Drugbank

DB13345 ; DB01365 ; DB00925 ; DB09244 ; DB00852 ; DB06694 ; DB00449 ; DB11738 ; DB01175 ; DB00246 ; DB00182 ; DB00408 ; DB00457 ; DB14185 ; DB00714 ; DB08815 ; DB13025 ; DB09242 ; DB00797 ; DB00800 ; DB04948 ; DB00320 ; DB01149 ; DB00715 ; DB06707 ; DB01608 ; DB01224 ; DB05492 ; DB00540 ; DB00589 ; DB00321 ; DB00575 ; DB01238 ; DB09194 ; DB00726 ; DB00968 ; DB04855 ; DB01624 ; DB01472 ; DB00865 ; DB00692 ; DB00477 ; DB00484 ; DB11278 ; DB00413 ; DB00543 ; DB01200 ; DB00696 ; DB01151 ; DB01403 ; DB06229 ; DB00193 ; DB00935 ; DB06678 ; DB00633 ; DB11577 ; DB00629 ; DB06148 ; DB01392 ; DB00668 ; DB06711 ; DB01267 ; DB01186 ; DB00217 ; DB00268 ; DB06216 ; DB00697 ; DB01577 ; DB01576 ; DB11273 ; DB09202 ; DB04846 ; DB00368 ; DB09229 ; DB11124 ; DB00433 ; DB09195 ; DB09167 ; DB00502 ; DB00370 ; DB00248 ; DB00363 ; DB00656 ; DB09286 ; DB00397 ; DB06153 ; DB06623 ; DB00964 ; DB09205 ; DB11477 ; DB01018 ; DB00934 ; DB01136 ; DB00555 ; DB06262 ; DB01049 ; DB09304 ; DB01363 ; DB00751 ; DB01069

KEGG

hsa:150

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Name: Dopamine

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Name: Progesterone

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Name: cocaine

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Name: yohimbine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 10)