Target Description

Type Detail
Target ID T07S0E
Protein Name BDNF/NT-3 growth factors receptor
Uniprot ID Q16620
Protein Name Alias EC 2.7.10.1;  GP145-TrkB;  Trk-B;  Neurotrophic tyrosine kinase receptor type 2;  TrkB tyrosine kinase;  Tropomyosin-related kinase B
Gene ID 4915
Gene Symbol NTRK2
Gene Alias TRKB
TTD T84703: Successful target
Pfam PF13855 ; PF16920 ; PF01462 ; PF07679 ; PF07714
GO
0014047:glutamate secretion

0021954:central nervous system neuron development

0043410:positive regulation of MAPK cascade

0048935:peripheral nervous system neuron development

0048403:brain-derived neurotrophic factor binding

0030424:axon

0005524:ATP binding

0051965:positive regulation of synapse assembly

0007631:feeding behavior

0030425:dendrite

1990416:cellular response to brain-derived neurotrophic factor stimulus

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0043197:dendritic spine

0031547:brain-derived neurotrophic factor receptor signaling pathway

0033138:positive regulation of peptidyl-serine phosphorylation

0046548:retinal rod cell development

0007612:learning

0019227:neuronal action potential propagation

0060291:long-term synaptic potentiation

0001934:positive regulation of protein phosphorylation

0007275:multicellular organism development

0043195:terminal bouton

0005829:cytosol

0030182:neuron differentiation

0048011:neurotrophin TRK receptor signaling pathway

1903997:positive regulation of non-membrane spanning protein tyrosine kinase activity

0001764:neuron migration

0046777:protein autophosphorylation

1990090:cellular response to nerve growth factor stimulus

0005030:neurotrophin receptor activity

0099183:trans-synaptic signaling by BDNF, modulating synaptic transmission

0031901:early endosome membrane

0001570:vasculogenesis

0005886:plasma membrane

0033674:positive regulation of kinase activity

0005887:integral component of plasma membrane

0099551:trans-synaptic signaling by neuropeptide, modulating synaptic transmission

0048471:perinuclear region of cytoplasm

0043121:neurotrophin binding

0021987:cerebral cortex development

0022011:myelination in peripheral nervous system

0043235:receptor complex

0042803:protein homodimerization activity

0048709:oligodendrocyte differentiation

0002020:protease binding

0043679:axon terminus

0008284:positive regulation of cell population proliferation

0071230:cellular response to amino acid stimulus

0050772:positive regulation of axonogenesis

0042490:mechanoreceptor differentiation

0043524:negative regulation of neuron apoptotic process

0010628:positive regulation of gene expression

0010976:positive regulation of neuron projection development

0005769:early endosome

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0051896:regulation of protein kinase B signaling

0014069:postsynaptic density

1902430:negative regulation of amyloid-beta formation

0007623:circadian rhythm

0060175:brain-derived neurotrophic factor-activated receptor activity

0043087:regulation of GTPase activity

0004714:transmembrane receptor protein tyrosine kinase activity

0007202:activation of phospholipase C activity

2000811:negative regulation of anoikis

PDB 5MO9 ; 4ASZ ; 4AT3 ; 1WWB ; 1HCF ; 2MFQ ; 4AT4 ; 4AT5
Drugbank DB11823 ; DB00321 ; DB14723 ; DB12010 ; DB11986
KEGG hsa:4915

Related Compounds  (Total: 5)

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C0074
Name: Fisetin
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C0263
Name: Oleic Acid
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C0699
Name: Ginsenoside Rf
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C0827
Name: 7,8-Dihydroxyflavone
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C1115
Name: cocaine


Related Herbs  (Total: 182)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H1079 Gan Di Huang干地黄 Adhesive rehmannia dried rootRehmannia glutinosa
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0086 Jiu Zi韭子 Tuber onion seedAllium tuberosum
H0473 Shu Di Huang熟地黄 Adhesive rehmannia cocked rootRehmannia glutinosa
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H1149 Hai Jin Sha Teng海金沙藤 NALygodium japonicum
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H0416 Shan Shen山参 NAPanax ginseng
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1148 Hai Jin Sha Cao海金沙草 NALygodium japonicum
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1223 Huai Hun Cao还魂草 NAAster tataricus
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H1150 Hai Jin Sha Teng Gan Jin Gao海金沙藤干浸膏 NALygodium japonicum
H0134 Li Zhi He荔枝核 Lychee seedLitchi chinensis
H0576 Tu Mu Xiang土木香 Elecampane inulaInula helenium
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0740 Yi Zhi益智 Fructus alpinae oxyphyllaeAlpinia oxyphylla
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H1229 Bai Mu Xiang白木香 Chinese eaglewoodAquilaria sinensis
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H1191 Hong Shen红参 Red ginsengRadix ginseng rubra
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0357 Ren Shen人参 GinsengPanax ginseng
H0224 Man Tuo Luo Ye曼陀罗叶 Hindu datura leafDatura metel
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0225 Man Tuo Luo Zi曼陀罗子 Hindu datura seedDatura metel
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H1156 Ai Di Huang矮地黄 RehmanniaeRehmannia glutinosa
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0739 Yi Yi Ren薏苡仁 Jobstears seedCoix lacryma- jobi var. ma - yuen
H0688 Xuan Shen玄参 Ningpo figwortScrophularia ningpoensis
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0204 Ma Ren麻仁 NACannabis sativa
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1147 Hai Jin Sha海金砂 Japanese climbing fernLygodium japonicum
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1131 Gui Ban龟板 Tortoise plastronPlastrum testudinis
H0770 Yuan Zhi Jin Gao远志浸膏 Thinleaf milkwortPolygala tenuifolia
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0769 Yuan Zhi远志 Thinleaf milkwortPolygala tenuifolia
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0768 Yuan Shen元参 Figwort rootScrophularia ningpoensis
H0079 Jiu Cai韭菜 Tuber onionAllium tuberosum
H0972 Di Huang地黄 RehmanniaeRehmannia glutinosa
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0720 Yang Jin Hua洋金花 Hindu datura flowerDatura metel
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0409 Shan Jiang山姜 shell gingerAlpinia zerumbet
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0743 Yi Zhi Ren益智仁 Sharpleaf galangalAlpinia oxyphylla
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0255 Mao Zhao Cao猫爪草 Root of catclaw buttercupRanunculus ternatus
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0527 Tao PeachPrunus persica
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H1110 Gua Lou Zi瓜蒌子 mongolian snakegourd seedTrichosanthes kirilowii maxim
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H1130 Guang Zao广枣 fruit of axillary choerospondiasFructus choerospondiatis
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0057 Jin Sha Teng金沙藤 NALygodium japonicum
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0054 Jin Niu Cao金牛草 NAPolygala glomerata
H0973 Di Huang Tan地黄炭 RehmanniaeRehmannia glutinosa
H0771 Yuan Zhi Liu Jin Gao远志流浸膏 Thinleaf milkwortPolygala tenuifolia
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta