Compound Description
| ID: C0074 | Common name: Fisetin |
| IUPAC: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one | CAS: CAS:528-48-3 |
| Chembl ID: CHEMBL31574 | Pubchem ID: CID:5281614 |
| Formula: C15H10O6 | TCM-ID: TCMC1174 |
| Smiles: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O | |
| Alias:
Fisetin;
Flavone, 3,3',4',7-tetrahydroxy-; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-benzopyran-4-one; 3,3',4',7-Tetrahydroxyflavone; 5-Desoxyquercetin; Bois Bleu de Honqrie; C.I. 75620; C.I. Natural Brown 1; Cotinin; Fiestin; Fietin; Fisetholz; Fisitin; Fustel; Fustet; Junger Fustik; LDN 0058389; NSC 407010; NSC 656275; Superfustel; Superfustel K; Ungarisches Gelbholz; Ventin Sumach; Viset; Young Fustic; Young Fustic Crystals; Zante Fustic |
Structure:
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Related Targets (Total: 39)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T20JZ2 | Androgen receptor | AR |
P10275 |
A | 2 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
A | 1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
A | 3 Reference(s) |
| T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
A | 1 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
A | 1 Reference(s) |
| T01E7W | Aurora kinase B | AURKB |
Q96GD4 |
A | 1 Reference(s) |
| T04NYZ | Disintegrin and metalloproteinase domain-containing protein 9 | ADAM9 |
Q13443 |
A | 1 Reference(s) |
| T67JR8 | Heat shock factor protein 1 | HSF1 |
Q00613 |
A | 1 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
B | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
B | 1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
B | 4 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
B | 1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
B | 3 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
B | 2 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
B | 3 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 4 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
B | 1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
B | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
B | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
B | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
B | 1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
B | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
B | 1 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
B | 1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
B | 1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
B | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T42K6K | M-phase inducer phosphatase 3 | CDC25C |
P30307 |
C | 1 Reference(s) |
| T33KFW | Matrilysin | MMP7 |
P09237 |
C | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
C | 1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
C | 1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
C | 1 Reference(s) |
| T85BSD | Mitogen-activated protein kinase kinase kinase 20 | MAP3K20 |
Q9NYL2 |
C | 1 Reference(s) |
| T72TF8 | Methylcytosine dioxygenase TET1 | TET1 |
Q8NFU7 |
C | 1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
C | 1 Reference(s) |
| T39WPZ | Mitogen-activated protein kinase 9 | MAPK9 |
P45984 |
C | 1 Reference(s) |
| T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
C | 1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
C | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 17)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0320 | Qi Shu Gen | 漆树根 | true lacquertree root | Toxicodendron succedaneum |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0092 | Ju Hua | 菊花 | Florists chrysanthemum flower | Chrysanthemum morifolium |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1161 | Hang Ju | 杭菊 | Chrysanthemum flower | Chrysanthemum morifolium |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
Ckey description of the interaction between compound and target