HIT-result

Target Description

Type	Detail
Target ID	T85BSD
Protein Name	Mitogen-activated protein kinase kinase kinase 20
Uniprot ID	Q9NYL2
Protein Name Alias	EC 2.7.11.25; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
Gene ID	51776
Gene Symbol	MAP3K20
Gene Alias	MLTK; ZAK
TTD	T97821: Research target
Pfam	PF00536 ; PF07714
GO	0005634:nucleus 0071480:cellular response to gamma radiation 0007050:cell cycle arrest 0106310:protein serine kinase activity 0005829:cytosol 0004674:protein serine/threonine kinase activity 0106311:protein threonine kinase activity 0008219:cell death 0042733:embryonic digit morphogenesis 0030154:cell differentiation 0060173:limb development 0005524:ATP binding 0000287:magnesium ion binding 0007257:activation of JUN kinase activity 1904291:positive regulation of mitotic DNA damage checkpoint 0003723:RNA binding 0051403:stress-activated MAPK cascade 0043065:positive regulation of apoptotic process 0006468:protein phosphorylation 0005737:cytoplasm 0000077:DNA damage checkpoint 0000186:activation of MAPKK activity 0007010:cytoskeleton organization 0004709:MAP kinase kinase kinase activity
PDB	5HES ; 6JUU ; 5X5O ; 6JUT
Drugbank	DB12010 ; DB01254
KEGG	hsa:51776

Type

Detail

Target ID

T85BSD

Protein Name

Mitogen-activated protein kinase kinase kinase 20

Uniprot ID

Q9NYL2

Protein Name Alias

EC 2.7.11.25; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK

Gene ID

51776

Gene Symbol

MAP3K20

Gene Alias

MLTK; ZAK

TTD

T97821: Research target

Pfam

PF00536 ; PF07714

0005634:nucleus

0071480:cellular response to gamma radiation

0007050:cell cycle arrest

0106310:protein serine kinase activity

0005829:cytosol

0004674:protein serine/threonine kinase activity

0106311:protein threonine kinase activity

0008219:cell death

0042733:embryonic digit morphogenesis

0030154:cell differentiation

0060173:limb development

0005524:ATP binding

0000287:magnesium ion binding

0007257:activation of JUN kinase activity

1904291:positive regulation of mitotic DNA damage checkpoint

0003723:RNA binding

0051403:stress-activated MAPK cascade

0043065:positive regulation of apoptotic process

0006468:protein phosphorylation

0005737:cytoplasm

0000077:DNA damage checkpoint

0000186:activation of MAPKK activity

0007010:cytoskeleton organization

0004709:MAP kinase kinase kinase activity

PDB

5HES ; 6JUU ; 5X5O ; 6JUT

Drugbank

DB12010 ; DB01254

KEGG

hsa:51776

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0320	Qi Shu Gen	漆树根	true lacquertree root	Toxicodendron succedaneum
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 17)