Target Description

Type Detail
Target ID T66S13
Protein Name Dual specificity mitogen-activated protein kinase kinase 2
Uniprot ID P36507
Protein Name Alias MAP kinase kinase 2;  MAPKK 2;  EC 2.7.12.2;  ERK activator kinase 2;  MAPK/ERK kinase 2;  MEK 2
Gene ID 5605
Gene Symbol MAP2K2
Gene Alias MEK2;  MKK2;  PRKMK2
TTD T89055: Clinical Trial target
Pfam PF00069
GO
0005634:nucleus

0005770:late endosome

0005925:focal adhesion

0106310:protein serine kinase activity

0005829:cytosol

0097110:scaffold protein binding

0032872:regulation of stress-activated MAPK cascade

0036289:peptidyl-serine autophosphorylation

0005778:peroxisomal membrane

0106311:protein threonine kinase activity

0005874:microtubule

0000187:activation of MAPK activity

0009898:cytoplasmic side of plasma membrane

0000165:MAPK cascade

2000641:regulation of early endosome to late endosome transport

1903800:positive regulation of production of miRNAs involved in gene silencing by miRNA

0005524:ATP binding

0005783:endoplasmic reticulum

0004712:protein serine/threonine/tyrosine kinase activity

0048471:perinuclear region of cytoplasm

0010629:negative regulation of gene expression

0070371:ERK1 and ERK2 cascade

0090170:regulation of Golgi inheritance

0045893:positive regulation of transcription, DNA-templated

0005576:extracellular region

0005794:Golgi apparatus

0005769:early endosome

0071902:positive regulation of protein serine/threonine kinase activity

0004714:transmembrane receptor protein tyrosine kinase activity

0005739:mitochondrion

0030165:PDZ domain binding

0005911:cell-cell junction

0046872:metal ion binding

0005078:MAP-kinase scaffold activity

0000186:activation of MAPKK activity

0043539:protein serine/threonine kinase activator activity

0004708:MAP kinase kinase activity

PDB 4H3Q ; 1S9I
Drugbank DB11967 ; DB12010 ; DB11689 ; DB06616 ; DB08911
KEGG hsa:5605

Related Compounds  (Total: 3)

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C0073
Name: Ferulic Acid
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C0074
Name: Fisetin
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C0435
Name: Terephthalic Acid


Related Herbs  (Total: 174)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0938 Da Suan大蒜 GarlicAllium sativum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0514 Cang Er Cao苍耳草 Cocklebur grassXanthium sibiricum
H1156 Ai Di Huang矮地黄 RehmanniaeRehmannia glutinosa
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H1052 Fu Fang Teng扶芳藤 Forture euonymusEuonymus fortunei
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0841 Chou Wu Tong臭梧桐 Harlequin glorybowerClerodendrum trichotomum
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0802 Zhi Geng枳梗 NACitrus aurantium
H0716 Yang Cong洋葱 Common onionAllium cepa
H0509 Cang Er苍耳 Siberian cockleburXanthium sibiricum
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0904 Ci Ji Li刺蒺藜 Puncturevine caltrapTribulus terrestris
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H1019 E Bu Shi Cao鹅不食草 Small centipedaCentipeda minima
H0628 Xi Xian Cao豨莶草 NASiegesbeckiae herba
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0566 Cao Cong Rong草苁蓉 Russian boschniakiaBoschniakia rossica
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0780 Zao Pi枣皮 VarietiesZiziphus jujuba mill. var. inermis (bge.) rehd.
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0158 Liu Ling Ju六棱菊 NALaggera alata
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0973 Di Huang Tan地黄炭 RehmanniaeRehmannia glutinosa
H0011 Ji Li蒺藜 Puncturevine caltrop fruitTribulus terrestris
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1116 Guan Mu Tong关木通 Manchurian dutchmanspipeAristolochia manshuriensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1079 Gan Di Huang干地黄 Adhesive rehmannia dried rootRehmannia glutinosa
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0447 Sheng Ma升麻 BugbaneCimicifuga foetida
H0717 Yang Cong Tou洋葱头 Common onionAllium cepa
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H1109 Bai Hua She She Cao白花蛇舌草 Spreading hedyitisOldenlandia diffusa
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H1121 Bai Ji Li白蒺藜 Tribulus fruitTribulus terrestris
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0100 Juan Bai卷柏 Tamariskoid spikemossSelaginella tamariscina
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0159 Ban Xia Qu半夏曲 Pinellia tuber leavenPinellia ternata
H0115 Kuan Dong Hua款冬花 Common coltsfootTussilago farfara
H0642 Xiang Jia Pi香加皮 Chinese silkvine root-barkPeriploca sepium
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0755 Ying Shan Hong映山红 Korean rhododendronRhododendron mucronulatum
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0075 Jing Mi粳米 RiceOryza sativa
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0473 Shu Di Huang熟地黄 Adhesive rehmannia cocked rootRehmannia glutinosa
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0688 Xuan Shen玄参 Ningpo figwortScrophularia ningpoensis
H0846 Chou Wu Tong Ye臭梧桐叶 Harlequin glorybowerClerodendrum trichotomum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0338 Qing Ban Xia清半夏 Ternate pinelliaPinellia ternata
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0377 San Ling三棱 Common burreedSparganium stoloniferum
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0768 Yuan Shen元参 Figwort rootScrophularia ningpoensis
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0439 Sheng Ban Xia生半夏 Ternate pinelliaPinellia ternata
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1020 E Bu Shi Cao Nong Suo Ye鹅不食草浓缩液 Small centipedaCentipeda minima
H0243 Mi Kuan Dong Hua蜜款冬花 Common coltsfootTussilago farfara
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0972 Di Huang地黄 RehmanniaeRehmannia glutinosa
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H0900 Chun Gen Pi椿根皮 Ailanthus bark, tree of heaven barkAilanthus altissima
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis