Compound Description
| ID: C0073 | Common name: Ferulic Acid |
| IUPAC: (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid | CAS: CAS:1135-24-6 |
| Chembl ID: CHEMBL32749 | Pubchem ID: CID:445858 |
| Formula: C10H10O4 | TCM-ID: TCMC1173 |
| Smiles: COc1cc(/C=C/C(=O)O)ccc1O | |
| Alias:
Cinnamic acid, 4-hydroxy-3-methoxy-;
3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; 3-(4-Hydroxy-3-methoxyphenyl)acrylic acid; 3-Methoxy-4-hydroxycinnamic acid; 4-Hydroxy-3-methoxycinnamic acid; 4'-Hydroxy-3'-methoxycinnamic acid; Coniferic acid; Ferulaic acid; Ferulic acid; NSC 2821; NSC 51986; NSC 674320 |
Structure:
|
Related Targets (Total: 16)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
A | 2 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
A | 1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
A | 1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
A | 1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
A | 1 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
C | 2 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
C | 1 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
C | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
C | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
C | 1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
C | 1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
C | 1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
C | 1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
C | 1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
C | 1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 158)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0566 | Cao Cong Rong | 草苁蓉 | Russian boschniakia | Boschniakia rossica |
| H1109 | Bai Hua She She Cao | 白花蛇舌草 | Spreading hedyitis | Oldenlandia diffusa |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H1228 | Huang Bai | 黄柏 | Amur corktree | Phellodendron amurense |
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H0159 | Ban Xia Qu | 半夏曲 | Pinellia tuber leaven | Pinellia ternata |
| H0897 | Chuan Lian | 川楝 | Chinaberry | Melia azedarach |
| H0365 | Rou Dou Kou | 肉豆蔻 | Common nutmeg | Myristica fragrans |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H1173 | Hei Chou | 黑丑 | Pharbitis seed | Semen pharbitidis |
| H1231 | Huang Bai Tan | 黄柏炭 | Amur corktree | Phellodendron amurense |
| H0893 | Chuan Xiong Jin Gao | 川芎浸膏 | cnidium officinale | Cnidium officinale |
| H0308 | Pi Ba Ren | 枇杷仁 | NA | Eriobotrya japonica |
| H0780 | Zao Pi | 枣皮 | Varieties | Ziziphus jujuba mill. var. inermis (bge.) rehd. |
| H0693 | Xue Xie | 血蝎 | Dragon's blood | Daemonorops draco |
| H0447 | Sheng Ma | 升麻 | Bugbane | Cimicifuga foetida |
| H0887 | Chuan Xin Lian Gan Jin Gao | 穿心莲干浸膏 | Common andrographis | Andrographis paniculata |
| H0690 | Xue Lian | 雪莲 | Snow lotus | Saussurea involucrata |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
| H1241 | Huang Lian | 黄连 | Coptis deltoidea | Coptis chinensis |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0755 | Ying Shan Hong | 映山红 | Korean rhododendron | Rhododendron mucronulatum |
| H1090 | Gao Ben | 藁本 | Chinese ligusticum | Ligusticum sinense |
| H1181 | Hei Zhi Ma | 黑芝麻 | Oriental sesame | Sesamum indicum |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H1115 | Guan Huang Bai | 关黄柏 | Amur cork tree | Phellodendron amurense |
| H0760 | Yu Huang Lian | 萸黄连 | Coptis deltoidea | Coptis chinensis |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0632 | Xia Ku Cao | 夏枯草 | Common selfheal | Prunella vulgaris |
| H0900 | Chun Gen Pi | 椿根皮 | Ailanthus bark, tree of heaven bark | Ailanthus altissima |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0973 | Di Huang Tan | 地黄炭 | Rehmanniae | Rehmannia glutinosa |
| H1011 | Bai Chou | 白丑 | Pharbitis seed | Semen pharbitidis |
| H0075 | Jing Mi | 粳米 | Rice | Oryza sativa |
| H0628 | Xi Xian Cao | 豨莶草 | NA | Siegesbeckiae herba |
| H0011 | Ji Li | 蒺藜 | Puncturevine caltrop fruit | Tribulus terrestris |
| H0892 | Chuan Xiong | 川芎 | cnidium officinale | Cnidium officinale |
| H0972 | Di Huang | 地黄 | Rehmanniae | Rehmannia glutinosa |
| H0514 | Cang Er Cao | 苍耳草 | Cocklebur grass | Xanthium sibiricum |
| H0765 | Chi Dou | 赤豆 | Assuki bean | Vigna angularis |
| H1207 | Hu Ma | 胡麻 | white seed of oriental sesame | Sesamum indicum |
| H1208 | Hu Ma Ren | 胡麻仁 | white seed of oriental sesame | Sesamum indicum |
| H1230 | Huang Bai Fen | 黄柏粉 | Amur corktree | Phellodendron amurense |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1138 | Bai Jiang Cao | 败酱草 | All - grass of dahurian patrinia | Thlaspi arvense |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H0338 | Qing Ban Xia | 清半夏 | Ternate pinellia | Pinellia ternata |
| H0082 | Jiu Huang Lian | 酒黄连 | Coptis deltoidea | Coptis chinensis |
| H0242 | Bei Sha Shen Liu Jin Gao | 北沙参流浸膏 | Glehnia littoralis | Glehnia littoralis |
| H0890 | Chuan Xin Lian Nong Suo Ye | 穿心莲浓缩液 | Common andrographis | Andrographis paniculata |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H1116 | Guan Mu Tong | 关木通 | Manchurian dutchmanspipe | Aristolochia manshuriensis |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H0868 | Chuan Du Huo | 川独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H1242 | Huang Lian Gan Jin Gao | 黄连干浸膏 | Coptis deltoidea | Coptis chinensis |
| H0938 | Da Suan | 大蒜 | Garlic | Allium sativum |
| H1079 | Gan Di Huang | 干地黄 | Adhesive rehmannia dried root | Rehmannia glutinosa |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H1220 | Hua Xiang Shu Guo | 化香树果 | NA | Platycarya strobilacea |
| H0704 | Yan Guan Huang Bai | 盐关黄柏 | Amur cork tree | Phellodendron amurense |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H0100 | Juan Bai | 卷柏 | Tamariskoid spikemoss | Selaginella tamariscina |
| H1183 | Hong Dou | 红豆 | Hosie ormosia | Ormosia hosiei |
| H0717 | Yang Cong Tou | 洋葱头 | Common onion | Allium cepa |
| H1052 | Fu Fang Teng | 扶芳藤 | Forture euonymus | Euonymus fortunei |
| H1221 | Hua Xiang Shu Guo Xu | 化香树果序 | NA | Platycarya strobilacea |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H0125 | Lai Fu | 莱菔 | Garden radish | Raphanus sativus |
| H0841 | Chou Wu Tong | 臭梧桐 | Harlequin glorybower | Clerodendrum trichotomum |
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0029 | Jiang Huang Lian | 姜黄连 | Coptis deltoidea | Coptis chinensis |
| H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
| H0108 | Ku Lian Pi | 苦楝皮 | Chinaberry-tree bark | Melia azedarach |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0275 | Mu Zei | 木贼 | Common scouring rush | Equisetum hiemale |
| H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
| H0509 | Cang Er | 苍耳 | Siberian cocklebur | Xanthium sibiricum |
| H0768 | Yuan Shen | 元参 | Figwort root | Scrophularia ningpoensis |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0642 | Xiang Jia Pi | 香加皮 | Chinese silkvine root-bark | Periploca sepium |
| H1121 | Bai Ji Li | 白蒺藜 | Tribulus fruit | Tribulus terrestris |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H1188 | Hong Hua | 红花 | Safflower | Carthamus tinctorius |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0688 | Xuan Shen | 玄参 | Ningpo figwort | Scrophularia ningpoensis |
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H1020 | E Bu Shi Cao Nong Suo Ye | 鹅不食草浓缩液 | Small centipeda | Centipeda minima |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0109 | Ku Lian Zi | 苦楝子 | NA | Melia azedarach |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0846 | Chou Wu Tong Ye | 臭梧桐叶 | Harlequin glorybower | Clerodendrum trichotomum |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0377 | San Ling | 三棱 | Common burreed | Sparganium stoloniferum |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0716 | Yang Cong | 洋葱 | Common onion | Allium cepa |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0126 | Lai Fu Zi | 莱菔子 | Garden radish seed | Raphanus sativus |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0158 | Liu Ling Ju | 六棱菊 | NA | Laggera alata |
| H1156 | Ai Di Huang | 矮地黄 | Rehmanniae | Rehmannia glutinosa |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0872 | Chuan Huang Lian | 川黄连 | rhizome of chinese goldthread | Coptis chinensis |
| H0473 | Shu Di Huang | 熟地黄 | Adhesive rehmannia cocked root | Rehmannia glutinosa |
| H1243 | Huang Lian Xu | 黄连须 | Coptis deltoidea | Coptis chinensis |
| H0682 | Xiong Huang Lian | 雄黄连 | Coptis deltoidea | Coptis chinensis |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
| H0155 | Ban Xia | 半夏 | Ternate pinellia | Pinellia ternata |
| H0546 | Tian Shan Xue Lian Hua | 天山雪莲花 | NA | Saussurea involucrata |
| H1009 | Du Huo | 独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H0243 | Mi Kuan Dong Hua | 蜜款冬花 | Common coltsfoot | Tussilago farfara |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H0056 | Jin Qiao Mai | 金荞麦 | Wild buckwheat rhizome | Rhizoma fagopyri cymosi |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H0886 | Chuan Xin Lian | 穿心莲 | Common andrographis | Andrographis paniculata |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
| H0439 | Sheng Ban Xia | 生半夏 | Ternate pinellia | Pinellia ternata |
| H0889 | Chuan Xin Lian Jin Gao | 穿心莲浸膏 | Common andrographis | Andrographis paniculata |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0904 | Ci Ji Li | 刺蒺藜 | Puncturevine caltrap | Tribulus terrestris |
| H0115 | Kuan Dong Hua | 款冬花 | Common coltsfoot | Tussilago farfara |
| H0785 | Ze Xi Huang Lian | 择细黄连 | Coptis deltoidea | Coptis chinensis |
| H0697 | Ya Ma Zi | 亚麻子 | Common flax seed | Linum usitatissimum |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0466 | Cai Fu Zi | 菜菔子 | Semen raphani | Raphanus sativus |
| H0691 | Xue Lian Hua | 雪莲花 | Snow lotus | Saussurea involucrata |
| H0006 | Bai Qu Cai | 白屈菜 | Greater celandine | Chelidonium majus |
| H0633 | Xia Tian Wu | 夏天无 | Decumbent corydalis | Corydalis decumbens |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H1019 | E Bu Shi Cao | 鹅不食草 | Small centipeda | Centipeda minima |
| H0239 | Bei Sha Shen | 北沙参 | Coastal glehnia | Glehnia littoralis |
| H0002 | Hui Xiang | 茴香 | Fennel fruit | Foeniculum vulgare |
Ckey description of the interaction between compound and target