Herb Description
| Herb ID: H0447 | Chinese Character: 升麻 |
| English Name: Bugbane | Latin Name: Cimicifuga foetida |
| Chinese Pin Yin : Sheng Ma | TCM-ID: TCMH1906 |
| Therapeutic Function in Chinese : 解表 | Therapeutic Function in English: For relieving exterior syndrome |
| Herb Function: Induce perspiration and promote eruption, remove toxic heat, and cure drooping and ptosis | |
Related Targets (Total: 64)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
3 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
3 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
2 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
2 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
2 Reference(s) |
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
1 Reference(s) |
| T54X6V | Intermediate conductance calcium-activated potassium channel protein 4 | KCNN4 |
O15554 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
3 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
1 Reference(s) |
| T24F1A | Pyruvate kinase PKLR | PKLR |
P30613 |
1 Reference(s) |
| T32JN2 | Beta-glucuronidase | GUSB |
P08236 |
1 Reference(s) |
| T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
2 Reference(s) |
| T22XGJ | Alpha-1A adrenergic receptor | ADRA1A |
P35348 |
2 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
1 Reference(s) |
| T68BGR | Glial fibrillary acidic protein | GFAP |
P14136 |
1 Reference(s) |
| T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
2 Reference(s) |
| T93R42 | Dipeptidyl peptidase 1 | CTSC |
P53634 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
1 Reference(s) |
| T47DIY | ATP-dependent 6-phosphofructokinase, muscle type | PFKM |
P08237 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
1 Reference(s) |
| T48J1U | Aldo-keto reductase family 1 member C1 | AKR1C1 |
Q04828 |
1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T92HNO | High mobility group protein B1 | HMGB1 |
P09429 |
1 Reference(s) |
| T23Z2G | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH |
P04406 |
1 Reference(s) |
| T97F4Y | High mobility group protein B3 | HMGB3 |
O15347 |
1 Reference(s) |
| T41S16 | Atrial natriuretic peptide receptor 3 | NPR3 |
P17342 |
1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
1 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
2 Reference(s) |
| T60UPF | Parvalbumin alpha | PVALB |
P20472 |
2 Reference(s) |
| T18CUI | Neuron-specific calcium-binding protein hippocalcin | HPCA |
P84074 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T39RV3 | Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 |
Q02750 |
1 Reference(s) |
| T66S13 | Dual specificity mitogen-activated protein kinase kinase 2 | MAP2K2 |
P36507 |
1 Reference(s) |
| T08SJX | Astrocytic phosphoprotein PEA-15 | PEA15 |
Q15121 |
1 Reference(s) |
| T38OQ4 | Peroxiredoxin-2 | PRDX2 |
P32119 |
1 Reference(s) |
| T38J3Y | Gamma-enolase | ENO2 |
P09104 |
1 Reference(s) |
| T02FO3 | Golgi-associated plant pathogenesis-related protein 1 | GLIPR2 |
Q9H4G4 |
1 Reference(s) |
| T10I26 | Interferon beta | IFNB1 |
P01574 |
1 Reference(s) |
| T14JSX | Plasminogen | PLG |
P00747 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
1 Reference(s) |
| T44S1A | Apolipoprotein A-I | APOA1 |
P02647 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T20PAH | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | FTH1 |
P02794 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
| T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
1 Reference(s) |
| T86DIE | Folate binding protein | NA |
Q6LDL1 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T18CPB | Choline O-acetyltransferase | CHAT |
P28329 |
1 Reference(s) |
Related Compounds (Total: 6)
C0149
Name: Isoferulic Acid
C1203
Name: Caffeic Acid
C0073
Name: Ferulic Acid
C0383
Name: Salicylic Acid
C0577
Name: Visnagin
key description of the interaction between compound and target