HIT-result

Target Description

Type	Detail
Target ID	T22XGJ
Protein Name	Alpha-1A adrenergic receptor
Uniprot ID	P35348
Protein Name Alias	Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c
Gene ID	148
Gene Symbol	ADRA1A
Gene Alias	ADRA1C
TTD	T92609: Successful target
Pfam	PF00001
GO	0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0005634:nucleus 0097195:pilomotor reflex 0005829:cytosol 0060073:micturition 0009725:response to hormone 0010507:negative regulation of autophagy 0098982:GABA-ergic synapse 0030018:Z disc 0098978:glutamatergic synapse 0060402:calcium ion transport into cytosol 0043231:intracellular membrane-bounded organelle 0035024:negative regulation of Rho protein signal transduction 0046982:protein heterodimerization activity 0007204:positive regulation of cytosolic calcium ion concentration 0045987:positive regulation of smooth muscle contraction 0099056:integral component of presynaptic membrane 0005901:caveola 0005654:nucleoplasm 1903997:positive regulation of non-membrane spanning protein tyrosine kinase activity 0006939:smooth muscle contraction 0001985:negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure 0007165:signal transduction 0043410:positive regulation of MAPK cascade 0031965:nuclear membrane 0035556:intracellular signal transduction 0001994:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure 0008285:negative regulation of cell population proliferation 0060452:positive regulation of cardiac muscle contraction 0098691:dopaminergic synapse 0150099:neuron-glial cell signaling 0007202:activation of phospholipase C activity 0045760:positive regulation of action potential 0006915:apoptotic process 0090037:positive regulation of protein kinase C signaling 2000300:regulation of synaptic vesicle exocytosis 0004937:alpha1-adrenergic receptor activity 0061049:cell growth involved in cardiac muscle cell development 0070374:positive regulation of ERK1 and ERK2 cascade 0004930:G protein-coupled receptor activity 0099055:integral component of postsynaptic membrane 0030315:T-tubule 0003084:positive regulation of systemic arterial blood pressure 0005886:plasma membrane 0007512:adult heart development 0045907:positive regulation of vasoconstriction 0007186:G protein-coupled receptor signaling pathway 0010613:positive regulation of cardiac muscle hypertrophy 0005887:integral component of plasma membrane 0042493:response to drug 0001996:positive regulation of heart rate by epinephrine-norepinephrine 0071880:adenylate cyclase-activating adrenergic receptor signaling pathway 0007568:aging 0007267:cell-cell signaling 0005737:cytoplasm 0032230:positive regulation of synaptic transmission, GABAergic 0001997:positive regulation of the force of heart contraction by epinephrine-norepinephrine
PDB	NA
Drugbank	DB13345 ; DB08950 ; DB00622 ; DB01365 ; DB00925 ; DB00458 ; DB00450 ; DB00852 ; DB06694 ; DB00449 ; DB01175 ; DB00346 ; DB00246 ; DB00182 ; DB00211 ; DB00408 ; DB00490 ; DB06764 ; DB00457 ; DB14185 ; DB00723 ; DB13025 ; DB00797 ; DB00800 ; DB04948 ; DB01149 ; DB00715 ; DB00590 ; DB06706 ; DB00420 ; DB01224 ; DB00610 ; DB05492 ; DB12278 ; DB00540 ; DB00321 ; DB00575 ; DB01238 ; DB09194 ; DB09203 ; DB00726 ; DB00243 ; DB09204 ; DB04855 ; DB01624 ; DB01472 ; DB00865 ; DB00692 ; DB01162 ; DB00477 ; DB00908 ; DB08922 ; DB11278 ; DB05469 ; DB00543 ; DB01200 ; DB00696 ; DB00298 ; DB01151 ; DB01403 ; DB01142 ; DB06229 ; DB00935 ; DB00661 ; DB00841 ; DB11577 ; DB06148 ; DB00668 ; DB06711 ; DB01267 ; DB01186 ; DB00268 ; DB06216 ; DB00734 ; DB00697 ; DB01576 ; DB11273 ; DB00598 ; DB09202 ; DB01295 ; DB00368 ; DB09229 ; DB11124 ; DB01253 ; DB00433 ; DB09195 ; DB01579 ; DB09167 ; DB00502 ; DB00875 ; DB00370 ; DB01364 ; DB00248 ; DB00363 ; DB06207 ; DB00656 ; DB00777 ; DB09286 ; DB00831 ; DB00679 ; DB04946 ; DB00388 ; DB06153 ; DB01614 ; DB00964 ; DB09205 ; DB06144 ; DB00934 ; DB01136 ; DB00555 ; DB06262 ; DB00699 ; DB01622 ; DB01049 ; DB00706 ; DB09239 ; DB00334 ; DB00751 ; DB01069
KEGG	hsa:148

Type

Detail

Target ID

T22XGJ

Protein Name

Alpha-1A adrenergic receptor

Uniprot ID

P35348

Protein Name Alias

Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c

Gene ID

148

Gene Symbol

ADRA1A

Gene Alias

ADRA1C

TTD

T92609: Successful target

Pfam

PF00001

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0005634:nucleus

0097195:pilomotor reflex

0005829:cytosol

0060073:micturition

0009725:response to hormone

0010507:negative regulation of autophagy

0098982:GABA-ergic synapse

0030018:Z disc

0098978:glutamatergic synapse

0060402:calcium ion transport into cytosol

0043231:intracellular membrane-bounded organelle

0035024:negative regulation of Rho protein signal transduction

0046982:protein heterodimerization activity

0007204:positive regulation of cytosolic calcium ion concentration

0045987:positive regulation of smooth muscle contraction

0099056:integral component of presynaptic membrane

0005901:caveola

0005654:nucleoplasm

1903997:positive regulation of non-membrane spanning protein tyrosine kinase activity

0006939:smooth muscle contraction

0001985:negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

0007165:signal transduction

0043410:positive regulation of MAPK cascade

0031965:nuclear membrane

0035556:intracellular signal transduction

0001994:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

0008285:negative regulation of cell population proliferation

0060452:positive regulation of cardiac muscle contraction

0098691:dopaminergic synapse

0150099:neuron-glial cell signaling

0007202:activation of phospholipase C activity

0045760:positive regulation of action potential

0006915:apoptotic process

0090037:positive regulation of protein kinase C signaling

2000300:regulation of synaptic vesicle exocytosis

0004937:alpha1-adrenergic receptor activity

0061049:cell growth involved in cardiac muscle cell development

0070374:positive regulation of ERK1 and ERK2 cascade

0004930:G protein-coupled receptor activity

0099055:integral component of postsynaptic membrane

0030315:T-tubule

0003084:positive regulation of systemic arterial blood pressure

0005886:plasma membrane

0007512:adult heart development

0045907:positive regulation of vasoconstriction

0007186:G protein-coupled receptor signaling pathway

0010613:positive regulation of cardiac muscle hypertrophy

0005887:integral component of plasma membrane

0042493:response to drug

0001996:positive regulation of heart rate by epinephrine-norepinephrine

0071880:adenylate cyclase-activating adrenergic receptor signaling pathway

0007568:aging

0007267:cell-cell signaling

0005737:cytoplasm

0032230:positive regulation of synaptic transmission, GABAergic

0001997:positive regulation of the force of heart contraction by epinephrine-norepinephrine

PDB

Drugbank

DB13345 ; DB08950 ; DB00622 ; DB01365 ; DB00925 ; DB00458 ; DB00450 ; DB00852 ; DB06694 ; DB00449 ; DB01175 ; DB00346 ; DB00246 ; DB00182 ; DB00211 ; DB00408 ; DB00490 ; DB06764 ; DB00457 ; DB14185 ; DB00723 ; DB13025 ; DB00797 ; DB00800 ; DB04948 ; DB01149 ; DB00715 ; DB00590 ; DB06706 ; DB00420 ; DB01224 ; DB00610 ; DB05492 ; DB12278 ; DB00540 ; DB00321 ; DB00575 ; DB01238 ; DB09194 ; DB09203 ; DB00726 ; DB00243 ; DB09204 ; DB04855 ; DB01624 ; DB01472 ; DB00865 ; DB00692 ; DB01162 ; DB00477 ; DB00908 ; DB08922 ; DB11278 ; DB05469 ; DB00543 ; DB01200 ; DB00696 ; DB00298 ; DB01151 ; DB01403 ; DB01142 ; DB06229 ; DB00935 ; DB00661 ; DB00841 ; DB11577 ; DB06148 ; DB00668 ; DB06711 ; DB01267 ; DB01186 ; DB00268 ; DB06216 ; DB00734 ; DB00697 ; DB01576 ; DB11273 ; DB00598 ; DB09202 ; DB01295 ; DB00368 ; DB09229 ; DB11124 ; DB01253 ; DB00433 ; DB09195 ; DB01579 ; DB09167 ; DB00502 ; DB00875 ; DB00370 ; DB01364 ; DB00248 ; DB00363 ; DB06207 ; DB00656 ; DB00777 ; DB09286 ; DB00831 ; DB00679 ; DB04946 ; DB00388 ; DB06153 ; DB01614 ; DB00964 ; DB09205 ; DB06144 ; DB00934 ; DB01136 ; DB00555 ; DB06262 ; DB00699 ; DB01622 ; DB01049 ; DB00706 ; DB09239 ; DB00334 ; DB00751 ; DB01069

KEGG

hsa:148

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0890	Chuan Xin Lian Nong Suo Ye	穿心莲浓缩液	Common andrographis	Andrographis paniculata
H0920	Da Ban Bian Lian	大半边莲	Asian lobelia	Lobelia chinensis
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0967	Di Er Cao	地耳草	Japanese stJohn’swort	Hypericum japonicum
H0243	Mi Kuan Dong Hua	蜜款冬花	Common coltsfoot	Tussilago farfara
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H0447	Sheng Ma	升麻	Bugbane	Cimicifuga foetida
H0887	Chuan Xin Lian Gan Jin Gao	穿心莲干浸膏	Common andrographis	Andrographis paniculata
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0886	Chuan Xin Lian	穿心莲	Common andrographis	Andrographis paniculata
H0671	Xie Cao	缬草	Common valeriana	Valeriana officinalis
H0113	Ban Bian Lian	半边莲	Chinese lobelia	Lobelia chinensis
H0889	Chuan Xin Lian Jin Gao	穿心莲浸膏	Common andrographis	Andrographis paniculata
H0839	Zhua Di Hu	抓地虎	Valerian	Valeriana officinalis
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0115	Kuan Dong Hua	款冬花	Common coltsfoot	Tussilago farfara
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H0116	Kuan Ye Xie Cao	宽叶缬草	NA	Valeriana officinalis
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0074	Jing Jie Tan	荆芥炭	NA	Schizonepetae herba
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 30)