HIT-result

Target Description

Type	Detail
Target ID	T04NYZ
Protein Name	Disintegrin and metalloproteinase domain-containing protein 9
Uniprot ID	Q13443
Protein Name Alias	ADAM 9; EC 3.4.24.-; Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase
Gene ID	8754
Gene Symbol	ADAM9
Gene Alias	KIAA0021; MCMP; MDC9; MLTNG
TTD	T03672: Clinical Trial target
Pfam	PF00200 ; PF01421 ; PF08516 ; PF01562
GO	0042542:response to hydrogen peroxide 0070062:extracellular exosome 0007155:cell adhesion 0007179:transforming growth factor beta receptor signaling pathway 0043236:laminin binding 0005925:focal adhesion 1902945:metalloendopeptidase activity involved in amyloid precursor protein catabolic process 0030335:positive regulation of cell migration 0010042:response to manganese ion 0006509:membrane protein ectodomain proteolysis 0008237:metallopeptidase activity 0033627:cell adhesion mediated by integrin 0050714:positive regulation of protein secretion 0031233:intrinsic component of external side of plasma membrane 0030216:keratinocyte differentiation 0071222:cellular response to lipopolysaccharide 0007160:cell-matrix adhesion 0004222:metalloendopeptidase activity 0042117:monocyte activation 0033630:positive regulation of cell adhesion mediated by integrin 0051592:response to calcium ion 0051549:positive regulation of keratinocyte migration 0005615:extracellular space 0005518:collagen binding 0034612:response to tumor necrosis factor 0042987:amyloid precursor protein catabolic process 0017124:SH3 domain binding 0016021:integral component of membrane 0005080:protein kinase C binding 0034241:positive regulation of macrophage fusion 0051384:response to glucocorticoid 0005178:integrin binding 0009986:cell surface 0007229:integrin-mediated signaling pathway 0016485:protein processing 0031293:membrane protein intracellular domain proteolysis 0016477:cell migration 0046872:metal ion binding 0000186:activation of MAPKK activity 0051044:positive regulation of membrane protein ectodomain proteolysis 0033631:cell-cell adhesion mediated by integrin
PDB	1M1V
Drugbank	DB05033
KEGG	hsa:8754

Type

Detail

Target ID

T04NYZ

Protein Name

Disintegrin and metalloproteinase domain-containing protein 9

Uniprot ID

Q13443

Protein Name Alias

ADAM 9; EC 3.4.24.-; Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase

Gene ID

8754

Gene Symbol

ADAM9

Gene Alias

KIAA0021; MCMP; MDC9; MLTNG

TTD

T03672: Clinical Trial target

Pfam

PF00200 ; PF01421 ; PF08516 ; PF01562

0042542:response to hydrogen peroxide

0070062:extracellular exosome

0007155:cell adhesion

0007179:transforming growth factor beta receptor signaling pathway

0043236:laminin binding

0005925:focal adhesion

1902945:metalloendopeptidase activity involved in amyloid precursor protein catabolic process

0030335:positive regulation of cell migration

0010042:response to manganese ion

0006509:membrane protein ectodomain proteolysis

0008237:metallopeptidase activity

0033627:cell adhesion mediated by integrin

0050714:positive regulation of protein secretion

0031233:intrinsic component of external side of plasma membrane

0030216:keratinocyte differentiation

0071222:cellular response to lipopolysaccharide

0007160:cell-matrix adhesion

0004222:metalloendopeptidase activity

0042117:monocyte activation

0033630:positive regulation of cell adhesion mediated by integrin

0051592:response to calcium ion

0051549:positive regulation of keratinocyte migration

0005615:extracellular space

0005518:collagen binding

0034612:response to tumor necrosis factor

0042987:amyloid precursor protein catabolic process

0017124:SH3 domain binding

0016021:integral component of membrane

0005080:protein kinase C binding

0034241:positive regulation of macrophage fusion

0051384:response to glucocorticoid

0005178:integrin binding

0009986:cell surface

0007229:integrin-mediated signaling pathway

0016485:protein processing

0031293:membrane protein intracellular domain proteolysis

0016477:cell migration

0046872:metal ion binding

0000186:activation of MAPKK activity

0051044:positive regulation of membrane protein ectodomain proteolysis

0033631:cell-cell adhesion mediated by integrin

PDB

1M1V

Drugbank

DB05033

KEGG

hsa:8754

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0457	Shi Er	石耳	Rock-Ears	Umbilicaria esculenta
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H1141	Guo Gang Long Jin Gao	过岗龙浸膏	NA	Entada phaseoloides
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1140	Guo Gang Long	过岗龙	NA	Entada phaseoloides
H0320	Qi Shu Gen	漆树根	true lacquertree root	Toxicodendron succedaneum
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 28)