Herb ID: H0695 | Chinese Character: 鸦胆子 |
English Name: Java brucea | Latin Name: Brucea javanica |
Chinese Pin Yin : Ya Dan Zi | TCM-ID: TCMH2360 |
Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
Herb Function: Remove toxic heat, stop malarial attacks, relieve dysentery, and cauterize vegetations |
Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
---|---|---|---|---|
T13KGH | Tyrosinase | TYR |
P14679 |
2 Reference(s) |
T31MUM | 5,6-dihydroxyindole-2-carboxylic acid oxidase | TYRP1 |
P17643 |
1 Reference(s) |
T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
4 Reference(s) |
T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
2 Reference(s) |
T77PFO | Histone deacetylase 6 | HDAC6 |
Q9UBN7 |
1 Reference(s) |
T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
T51IKV | DNA topoisomerase 2-alpha | TOP2A |
P11388 |
1 Reference(s) |
T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
4 Reference(s) |
T32R5L | Cyclin-dependent kinase 9 | CDK9 |
P50750 |
1 Reference(s) |
T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
40 Reference(s) |
T62UOD | Serine/threonine-protein kinase VRK1 | VRK1 |
Q99986 |
1 Reference(s) |
T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
T60B3R | Glutathione S-transferase kappa 1 | GSTK1 |
Q9Y2Q3 |
1 Reference(s) |
T67CB6 | Transcriptional regulator ERG | ERG |
P11308 |
1 Reference(s) |
T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
1 Reference(s) |
T11NOZ | NA | MIR132 |
NA |
1 Reference(s) |
T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
1 Reference(s) |
T68DAN | Histone deacetylase 9 | HDAC9 |
Q9UKV0 |
1 Reference(s) |
T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
T91AIW | Receptor-type tyrosine-protein kinase FLT3 | FLT3 |
P36888 |
1 Reference(s) |
T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
7 Reference(s) |
T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
2 Reference(s) |
T29B10 | Interleukin-17A | IL17A |
Q16552 |
1 Reference(s) |
T38O11 | Cyclin-G-associated kinase | GAK |
O14976 |
1 Reference(s) |
T30VNV | Myeloperoxidase | MPO |
P05164 |
1 Reference(s) |
T62P0D | Collagenase 3 | MMP13 |
P45452 |
1 Reference(s) |
T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
9 Reference(s) |
T74WWP | Peroxisome proliferator-activated receptor delta | PPARD |
Q03181 |
1 Reference(s) |
T14JSX | Plasminogen | PLG |
P00747 |
1 Reference(s) |
T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
3 Reference(s) |
T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
T67LRH | RNA-binding protein Musashi homolog 1 | MSI1 |
O43347 |
1 Reference(s) |
T70KPE | Transient receptor potential cation channel subfamily V member 3 | TRPV3 |
Q8NET8 |
1 Reference(s) |
T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
3 Reference(s) |
T26KIE | Transcription factor AP-1 | JUN |
P05412 |
5 Reference(s) |
T06VX0 | MAP/microtubule affinity-regulating kinase 4 | MARK4 |
Q96L34 |
3 Reference(s) |
T98QOA | DNA-dependent protein kinase catalytic subunit | PRKDC |
P78527 |
2 Reference(s) |
T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
4 Reference(s) |
T31EJG | Apoptotic protease-activating factor 1 | APAF1 |
O14727 |
1 Reference(s) |
T09INZ | Transient receptor potential cation channel subfamily A member 1 | TRPA1 |
O75762 |
1 Reference(s) |
T35QZO | Cytochrome c | CYCS |
P99999 |
1 Reference(s) |
T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
2 Reference(s) |
T37G49 | Platelet-activating factor acetylhydrolase | PLA2G7 |
Q13093 |
1 Reference(s) |
T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
2 Reference(s) |
T44LWL | Transcription factor p65 | RELA |
Q04206 |
1 Reference(s) |
T23P74 | Caspase-9 | CASP9 |
P55211 |
4 Reference(s) |
T85U8U | Caspase-3 | CASP3 |
P42574 |
7 Reference(s) |
T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
2 Reference(s) |
T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
5 Reference(s) |
T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
1 Reference(s) |
T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
T20IHC | Diacylglycerol O-acyltransferase 1 | DGAT1 |
O75907 |
1 Reference(s) |
T16UZ4 | Dipeptidyl peptidase 4 | DPP4 |
P27487 |
1 Reference(s) |
T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
2 Reference(s) |
T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
T22H8P | Carbonic anhydrase 3 | CA3 |
P07451 |
1 Reference(s) |
T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
3 Reference(s) |
T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
1 Reference(s) |
T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
5 Reference(s) |
T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
1 Reference(s) |
T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
3 Reference(s) |
T33OPP | Interleukin-6 | IL6 |
P05231 |
3 Reference(s) |
T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
2 Reference(s) |
T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
3 Reference(s) |
T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
4 Reference(s) |
T47HTN | Prostaglandin E synthase | PTGES |
O14684 |
1 Reference(s) |
T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
2 Reference(s) |
T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
3 Reference(s) |
T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
1 Reference(s) |
T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
1 Reference(s) |
T06PVX | E3 ubiquitin-protein ligase Mdm2 | MDM2 |
Q00987 |
1 Reference(s) |
T92AMR | Hepatocyte growth factor receptor | MET |
P08581 |
1 Reference(s) |
T23VMI | Tumor necrosis factor | TNF |
P01375 |
4 Reference(s) |
T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
T69NG6 | Interleukin-10 | IL10 |
P22301 |
2 Reference(s) |
T37VLU | Interferon gamma | IFNG |
P01579 |
1 Reference(s) |
T88B8X | Insulin receptor | INSR |
P06213 |
1 Reference(s) |
T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
2 Reference(s) |
T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
T60GGR | Serine/threonine-protein kinase TBK1 | TBK1 |
Q9UHD2 |
1 Reference(s) |
T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
T01E7W | Aurora kinase B | AURKB |
Q96GD4 |
1 Reference(s) |
T77M4W | Adenosine receptor A2a | ADORA2A |
P29274 |
1 Reference(s) |
T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
1 Reference(s) |
T35LKG | Adenosine receptor A1 | ADORA1 |
P30542 |
1 Reference(s) |
T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
1 Reference(s) |
T39YFG | Trypsin-1 | PRSS1 |
P07477 |
1 Reference(s) |
T54WR0 | Fatty acid-binding protein 5 | FABP5 |
Q01469 |
1 Reference(s) |
T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
T07S0E | BDNF/NT-3 growth factors receptor | NTRK2 |
Q16620 |
1 Reference(s) |
T90XYZ | C-reactive protein | CRP |
P02741 |
1 Reference(s) |
T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
1 Reference(s) |
T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
1 Reference(s) |
T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
T38WWN | Serum paraoxonase/arylesterase 1 | PON1 |
P27169 |
1 Reference(s) |
T23YZF | Peptidyl-glycine alpha-amidating monooxygenase | PAM |
P19021 |
1 Reference(s) |
T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
T93VFT | Endothelin-1 | EDN1 |
P05305 |
1 Reference(s) |
T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
T02DEN | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide | GCG |
P01275 |
1 Reference(s) |
T48UT8 | Cholesteryl ester transfer protein | CETP |
P11597 |
1 Reference(s) |
T32HPO | Aspartyl aminopeptidase | DNPEP |
Q9ULA0 |
1 Reference(s) |
T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
T02YLA | Alpha-lactalbumin | LALBA |
P00709 |
1 Reference(s) |
T90SGJ | Caspase-2 | CASP2 |
P42575 |
1 Reference(s) |
T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
T52YQN | Caspase-10 | CASP10 |
Q92851 |
1 Reference(s) |
T01QLH | Estrogen receptor | ESR1 |
P03372 |
2 Reference(s) |
T76TED | Pro-opiomelanocortin | POMC |
P01189 |
1 Reference(s) |
T37JN5 | Neutrophil gelatinase-associated lipocalin | LCN2 |
P80188 |
1 Reference(s) |
T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
1 Reference(s) |
T18CWB | Transcriptional activator Myb | MYB |
P10242 |
1 Reference(s) |
T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
2 Reference(s) |
T97KL5 | Microsomal glutathione S-transferase 1 | MGST1 |
P10620 |
2 Reference(s) |
T81BH5 | Sulfotransferase 1A1 | SULT1A1 |
P50225 |
2 Reference(s) |
T32SPJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PIK3CG |
P48736 |
1 Reference(s) |
T04V7K | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | ENPP7 |
Q6UWV6 |
1 Reference(s) |
T51U9M | Carnitine O-palmitoyltransferase 1, muscle isoform | CPT1B |
Q92523 |
1 Reference(s) |
T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
1 Reference(s) |
T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
1 Reference(s) |
T68AKE | Zinc fingers and homeoboxes protein 2 | ZHX2 |
Q9Y6X8 |
1 Reference(s) |
T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
1 Reference(s) |
T10K5R | NA | MIR203A |
NA |
1 Reference(s) |
T66WWM | Claudin-2 | CLDN2 |
P57739 |
2 Reference(s) |
T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
1 Reference(s) |
T92HNO | High mobility group protein B1 | HMGB1 |
P09429 |
1 Reference(s) |
T78IOY | Telomerase reverse transcriptase | TERT |
O14746 |
1 Reference(s) |
T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
1 Reference(s) |
T41DXP | Pleiotrophin | PTN |
P21246 |
1 Reference(s) |
T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
T62RLH | NA | MIR384 |
NA |
1 Reference(s) |
T67RBZ | Mitochondrial uncoupling protein 2 | UCP2 |
P55851 |
1 Reference(s) |
T67HYX | Mitochondrial uncoupling protein 3 | UCP3 |
P55916 |
1 Reference(s) |
T19EKF | Cholecystokinin | CCK |
P06307 |
1 Reference(s) |
T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
1 Reference(s) |
T23APZ | Retinol-binding protein 2 | RBP2 |
P50120 |
1 Reference(s) |
T03NWF | Sterol O-acyltransferase 1 | SOAT1 |
P35610 |
1 Reference(s) |
T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
T53SLQ | Aquaporin-9 | AQP9 |
O43315 |
1 Reference(s) |
T75EH8 | Glucagon-like peptide 1 receptor | GLP1R |
P43220 |
1 Reference(s) |
T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
1 Reference(s) |
T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
1 Reference(s) |
T27M4K | Rho GTPase-activating protein 7 | DLC1 |
Q96QB1 |
1 Reference(s) |
T52ARL | Suppressor of cytokine signaling 3 | SOCS3 |
O14543 |
1 Reference(s) |
T08VHE | Probable threonine protease PRSS50 | PRSS50 |
Q9UI38 |
1 Reference(s) |
T85NRC | Pyruvate kinase PKM | PKM |
P14618 |
1 Reference(s) |
T98DNG | Natriuretic peptides A | NPPA |
P01160 |
1 Reference(s) |
T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
T68IZC | Natriuretic peptides B | NPPB |
P16860 |
1 Reference(s) |
T02H9U | Nuclear factor of activated T-cells, cytoplasmic 4 | NFATC4 |
Q14934 |
1 Reference(s) |
T52T5O | Axin-1 | AXIN1 |
O15169 |
1 Reference(s) |
T06YQX | Frizzled-8 | FZD8 |
Q9H461 |
1 Reference(s) |
T81R79 | Protein Wnt-5a | WNT5A |
P41221 |
1 Reference(s) |
T06IYF | Adenomatous polyposis coli protein | APC |
P25054 |
1 Reference(s) |
T08B2M | M-phase inducer phosphatase 1 | CDC25A |
P30304 |
1 Reference(s) |
T33UEM | Lactoperoxidase | LPO |
P22079 |
1 Reference(s) |
T03TJ0 | Interleukin-33 | IL33 |
O95760 |
1 Reference(s) |
T40G6B | Prostaglandin reductase 1 | PTGR1 |
Q14914 |
1 Reference(s) |
T31VDH | Myeloid differentiation primary response protein MyD88 | MYD88 |
Q99836 |
1 Reference(s) |
T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
1 Reference(s) |