HIT-result

Type	Detail
Target ID	T81R79
Protein Name	Protein Wnt-5a
Uniprot ID	P41221
Protein Name Alias	NA
Gene ID	7474
Gene Symbol	WNT5A
Gene Alias	NA
TTD	T13175: Research target
Pfam	PF00110
GO	0010820:positive regulation of T cell chemotaxis 0019904:protein domain specific binding 2000049:positive regulation of cell-cell adhesion mediated by cadherin 1904934:negative regulation of cell proliferation in midbrain 0007223:Wnt signaling pathway, calcium modulating pathway 0098978:glutamatergic synapse 0060744:mammary gland branching involved in thelarche 0032755:positive regulation of interleukin-6 production 0061024:membrane organization 0035567:non-canonical Wnt signaling pathway 1904955:planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation 0032729:positive regulation of interferon-gamma production 0001837:epithelial to mesenchymal transition 0038031:non-canonical Wnt signaling pathway via JNK cascade 0060638:mesenchymal-epithelial cell signaling 0010033:response to organic substance 0045778:positive regulation of ossification 0050680:negative regulation of epithelial cell proliferation 0031012:extracellular matrix 0060809:mesodermal to mesenchymal transition involved in gastrulation 0032092:positive regulation of protein binding 0001822:kidney development 0002720:positive regulation of cytokine production involved in immune response 0007257:activation of JUN kinase activity 0030514:negative regulation of BMP signaling pathway 0050729:positive regulation of inflammatory response 0005796:Golgi lumen 0061348:planar cell polarity pathway involved in ventricular septum morphogenesis 0005576:extracellular region 0003283:atrial septum development 0045766:positive regulation of angiogenesis 0010800:positive regulation of peptidyl-threonine phosphorylation 0061347:planar cell polarity pathway involved in outflow tract morphogenesis 0060907:positive regulation of macrophage cytokine production 0090179:planar cell polarity pathway involved in neural tube closure 0036342:post-anal tail morphogenesis 0051964:negative regulation of synapse assembly 0099566:regulation of postsynaptic cytosolic calcium ion concentration 0045599:negative regulation of fat cell differentiation 0060760:positive regulation of response to cytokine stimulus 0045944:positive regulation of transcription by RNA polymerase II 0043066:negative regulation of apoptotic process 1903827:regulation of cellular protein localization 0060067:cervix development 0061349:planar cell polarity pathway involved in cardiac right atrium morphogenesis 0060071:Wnt signaling pathway, planar cell polarity pathway 0048018:receptor ligand activity 0045807:positive regulation of endocytosis 0010976:positive regulation of neuron projection development 0062009:secondary palate development 0099054:presynapse assembly 0048570:notochord morphogenesis 0030216:keratinocyte differentiation 0071222:cellular response to lipopolysaccharide 0048341:paraxial mesoderm formation 0060775:planar cell polarity pathway involved in gastrula mediolateral intercalation 0007494:midgut development 0060762:regulation of branching involved in mammary gland duct morphogenesis 0061350:planar cell polarity pathway involved in cardiac muscle tissue morphogenesis 0001736:establishment of planar polarity 0032148:activation of protein kinase B activity 0099175:regulation of postsynapse organization 0046330:positive regulation of JNK cascade 0005615:extracellular space 0030669:clathrin-coated endocytic vesicle membrane 0043122:regulation of I-kappaB kinase/NF-kappaB signaling 0010628:positive regulation of gene expression 0045165:cell fate commitment 0002053:positive regulation of mesenchymal cell proliferation 2000052:positive regulation of non-canonical Wnt signaling pathway 1902379:chemoattractant activity involved in axon guidance 0060599:lateral sprouting involved in mammary gland duct morphogenesis 0036517:chemoattraction of serotonergic neuron axon 1901216:positive regulation of neuron death 0070245:positive regulation of thymocyte apoptotic process 0071277:cellular response to calcium ion 0097325:melanocyte proliferation 0032757:positive regulation of interleukin-8 production 0006468:protein phosphorylation 0071300:cellular response to retinoic acid 0032760:positive regulation of tumor necrosis factor production 0045198:establishment of epithelial cell apical/basal polarity 0007442:hindgut morphogenesis 1904861:excitatory synapse assembly 0090090:negative regulation of canonical Wnt signaling pathway 0033138:positive regulation of peptidyl-serine phosphorylation 0042060:wound healing 0003408:optic cup formation involved in camera-type eye development 0099068:postsynapse assembly 0060028:convergent extension involved in axis elongation 0045836:positive regulation of meiotic nuclear division 0061354:planar cell polarity pathway involved in pericardium morphogenesis 0030182:neuron differentiation 0001756:somitogenesis 1904862:inhibitory synapse assembly 0001938:positive regulation of endothelial cell proliferation 0060340:positive regulation of type I interferon-mediated signaling pathway 0030324:lung development 0048146:positive regulation of fibroblast proliferation 0005543:phospholipid binding 0048022:negative regulation of melanin biosynthetic process 0003139:secondary heart field specification 1902474:positive regulation of protein localization to synapse 0048850:hypophysis morphogenesis 0031343:positive regulation of cell killing 0032722:positive regulation of chemokine production 0071346:cellular response to interferon-gamma 0005125:cytokine activity 0016055:Wnt signaling pathway 0034613:cellular protein localization 1900020:positive regulation of protein kinase C activity 0060065:uterus development 1904953:Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 0090630:activation of GTPase activity 0009986:cell surface 0045732:positive regulation of protein catabolic process 0060324:face development 0060157:urinary bladder development 0072201:negative regulation of mesenchymal cell proliferation 0032731:positive regulation of interleukin-1 beta production 0045893:positive regulation of transcription, DNA-templated 0050727:regulation of inflammatory response 0003323:type B pancreatic cell development 0060068:vagina development 0005115:receptor tyrosine kinase-like orphan receptor binding 0003138:primary heart field specification 0005788:endoplasmic reticulum lumen 0050807:regulation of synapse organization 0040037:negative regulation of fibroblast growth factor receptor signaling pathway 0005109:frizzled binding 0070062:extracellular exosome 0061036:positive regulation of cartilage development 0030666:endocytic vesicle membrane 0071425:hematopoietic stem cell proliferation 0098794:postsynapse 0048806:genitalia development 0008595:anterior/posterior axis specification, embryo 0001947:heart looping 0010595:positive regulation of endothelial cell migration 0048706:embryonic skeletal system development 0071560:cellular response to transforming growth factor beta stimulus 0042733:embryonic digit morphogenesis 0051885:positive regulation of timing of anagen 0045892:negative regulation of transcription, DNA-templated 0000187:activation of MAPK activity 0051092:positive regulation of NF-kappaB transcription factor activity 0051216:cartilage development 0002088:lens development in camera-type eye 0060070:canonical Wnt signaling pathway 0005886:plasma membrane 0060029:convergent extension involved in organogenesis 0036518:chemorepulsion of dopaminergic neuron axon 0048843:negative regulation of axon extension involved in axon guidance 0008584:male gonad development 1904938:planar cell polarity pathway involved in axon guidance 0090009:primitive streak formation 0060686:negative regulation of prostatic bud formation 0090103:cochlea morphogenesis 0021891:olfactory bulb interneuron development 0003402:planar cell polarity pathway involved in axis elongation 0043032:positive regulation of macrophage activation 0090037:positive regulation of protein kinase C signaling 0060750:epithelial cell proliferation involved in mammary gland duct elongation 0150012:positive regulation of neuron projection arborization 0090082:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway 0007411:axon guidance
PDB	NA
Drugbank	NA
KEGG	hsa:7474

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 1)