Target Description

Type Detail
Target ID T91AIW
Protein Name Receptor-type tyrosine-protein kinase FLT3
Uniprot ID P36888
Protein Name Alias EC 2.7.10.1;  FL cytokine receptor;  Fetal liver kinase-2;  FLK-2;  Fms-like tyrosine kinase 3;  FLT-3;  Stem cell tyrosine kinase 1;  STK-1;  CD antigen CD135
Gene ID 2322
Gene Symbol FLT3
Gene Alias CD135;  FLK2;  STK1
TTD T74312: Successful target
Pfam PF00047 ; PF07714
GO
0005634:nucleus

0043235:receptor complex

0007275:multicellular organism development

0043410:positive regulation of MAPK cascade

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0046777:protein autophosphorylation

0042981:regulation of apoptotic process

0018108:peptidyl-tyrosine phosphorylation

0035259:glucocorticoid receptor binding

0005788:endoplasmic reticulum lumen

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0071345:cellular response to cytokine stimulus

0046651:lymphocyte proliferation

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0097028:dendritic cell differentiation

0010243:response to organonitrogen compound

0008284:positive regulation of cell population proliferation

0051897:positive regulation of protein kinase B signaling

0005021:vascular endothelial growth factor-activated receptor activity

0002328:pro-B cell differentiation

0019838:growth factor binding

0000165:MAPK cascade

0005887:integral component of plasma membrane

0044877:protein-containing complex binding

0005829:cytosol

0005524:ATP binding

0005783:endoplasmic reticulum

0005886:plasma membrane

0030183:B cell differentiation

0071385:cellular response to glucocorticoid stimulus

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0030097:hemopoiesis

0031100:animal organ regeneration

0002318:myeloid progenitor cell differentiation

0043406:positive regulation of MAP kinase activity

0004714:transmembrane receptor protein tyrosine kinase activity

0016032:viral process

0033674:positive regulation of kinase activity

0035726:common myeloid progenitor cell proliferation

0004896:cytokine receptor activity

0019221:cytokine-mediated signaling pathway

0001776:leukocyte homeostasis

0043621:protein self-association

0010008:endosome membrane

PDB 5X02 ; 6IL3 ; 1RJB ; 3QS9 ; 4RT7 ; 3QS7 ; 4XUF ; 6JQR
Drugbank DB12874 ; DB08901 ; DB12267 ; DB05014 ; DB01268 ; DB09079 ; DB05465 ; DB12500 ; DB12010 ; DB12742 ; DB12141 ; DB06469 ; DB12978 ; DB06080 ; DB06595 ; DB15822 ; DB00398
KEGG hsa:2322

Related Compounds  (Total: 3)

Go to browser
C0199
Name: Luteolin
Go to browser
C0612
Name: Crotonoside
Go to browser
C1260
Name: Coumestrol


Related Herbs  (Total: 159)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H0183 Luo Hua Sheng Zhi Ye落花生枝叶 Peanut branch-leafArachis hypogaea
H0026 Jiang Soybean pasteGlycine max
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H1007 Dou You豆油 Soybean oilGlycine max
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0730 Ye Ma Zhui野马追 NAEupatorium lindleyanum
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0247 Mi Meng Hua密蒙花 Pale butterflybushBuddleja officinalis
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0516 Suan Zao酸枣 Spine dateZiziphus jujuba var. spinosa
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0010 Ji Guan Hua鸡冠花 Common cockscomb flowerCelosia cristata
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H1219 Hua Sheng Mi花生米 NAArachis hypogaea
H1218 Hua Sheng花生 NAArachis hypogaea
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0781 Zao Ren枣仁 seed of spine dateZiziphus jujuba var. spinosa
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0517 Suan Zao Ren酸枣仁 Spine date seedZiziphus jujuba var. spinosa
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0727 Ye Gan Cao野甘草 Sweet broomwortScoparia dulcis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0204 Ma Ren麻仁 NACannabis sativa
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H1160 Han Xin Cao韩信草 Indian skullcapScutellaria indica
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius