Compound Description

ID:   C0199 Common name:   Luteolin
IUPAC:  2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one CAS:  CAS:491-70-3
Chembl ID:   CHEMBL151 Pubchem ID:   CID:5280445
Formula:  C15H10O6 TCM-ID:  TCMC1516
Smiles:  C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O
Alias:

Flavone, 3',4',5,7-tetrahydroxy-;

Luteolin;

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-benzopyran-4-one;

3',4',5,7-Tetrahydroxyflavone;

5,7,3',4'-Tetrahydroxyflavone;

Cyanidenon;

Cyanidenon 1470;

Digitoflavone;

Flacitran;

Luteoline;

Luteolol;

Salifazide;

Weld lake;

Yama Kariyasu
Structure:

Related Targets  (Total: 79)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T51IKV DNA topoisomerase 2-alphaTOP2A P11388
A 1 Reference(s)
T87DEX Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseXDH P47989
A 4 Reference(s)
T32R5L Cyclin-dependent kinase 9CDK9 P50750
A 1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
A 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
A 2 Reference(s)
T62UOD Serine/threonine-protein kinase VRK1VRK1 Q99986
A 1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
A 1 Reference(s)
T60B3R Glutathione S-transferase kappa 1GSTK1 Q9Y2Q3
A 1 Reference(s)
T67CB6 Transcriptional regulator ERGERG P11308
A 1 Reference(s)
T39M6J ATP-binding cassette sub-family C member 2ABCC2 Q92887
A 1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
A 1 Reference(s)
T11NOZ NAMIR132 NA
A 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
A 1 Reference(s)
T68DAN Histone deacetylase 9HDAC9 Q9UKV0
A 1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
A 1 Reference(s)
T91AIW Receptor-type tyrosine-protein kinase FLT3FLT3 P36888
A 1 Reference(s)
T25M2J Anoctamin-1ANO1 Q5XXA6
A 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
A 2 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
A 1 Reference(s)
T29B10 Interleukin-17AIL17A Q16552
A 1 Reference(s)
T38O11 Cyclin-G-associated kinaseGAK O14976
A 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
B 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
B 1 Reference(s)
T99XQ3 DNA topoisomerase 1TOP1 P11387
B 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
B 1 Reference(s)
T14LSK E3 ubiquitin-protein ligase XIAPXIAP P98170
B 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
B 3 Reference(s)
T13KGH TyrosinaseTYR P14679
B 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
B 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
B 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
B 3 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
B 3 Reference(s)
T85U8U Caspase-3CASP3 P42574
B 3 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
B 2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
B 3 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
B 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
B 4 Reference(s)
T47HTN Prostaglandin E synthasePTGES O14684
B 1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
B 1 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
B 2 Reference(s)
T50V79 Interleukin-4IL4 P05112
B 1 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
B 1 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
B 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
B 1 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
B 1 Reference(s)
T75HMM Induced myeloid leukemia cell differentiation protein Mcl-1MCL1 Q07820
B 1 Reference(s)
T74I49 Bcl-2-like protein 1BCL2L1 Q07817
B 1 Reference(s)
T06PVX E3 ubiquitin-protein ligase Mdm2MDM2 Q00987
B 1 Reference(s)
T92AMR Hepatocyte growth factor receptorMET P08581
B 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
B 3 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
B 6 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
B 1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
B 1 Reference(s)
T37VLU Interferon gammaIFNG P01579
B 1 Reference(s)
T88B8X Insulin receptorINSR P06213
B 1 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
B 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
B 1 Reference(s)
T60GGR Serine/threonine-protein kinase TBK1TBK1 Q9UHD2
B 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
B 1 Reference(s)
T01E7W Aurora kinase BAURKB Q96GD4
B 1 Reference(s)
T77M4W Adenosine receptor A2aADORA2A P29274
B 1 Reference(s)
T62Y4H Protein kinase C epsilon typePRKCE Q02156
B 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
B 1 Reference(s)
T35LKG Adenosine receptor A1ADORA1 P30542
B 1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
B 1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
C 1 Reference(s)
T68AKE Zinc fingers and homeoboxes protein 2ZHX2 Q9Y6X8
C 1 Reference(s)
T73LPO Poly [ADP-ribose] polymerase 1PARP1 P09874
C 1 Reference(s)
T10K5R NAMIR203A NA
C 1 Reference(s)
T66WWM Claudin-2CLDN2 P57739
C 2 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
C 1 Reference(s)
T92HNO High mobility group protein B1HMGB1 P09429
C 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
C 1 Reference(s)
T78IOY Telomerase reverse transcriptaseTERT O14746
C 1 Reference(s)
T41BXR NAD-dependent protein deacetylase sirtuin-3, mitochondrialSIRT3 Q9NTG7
C 1 Reference(s)
T41DXP PleiotrophinPTN P21246
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
C 1 Reference(s)
T62RLH NAMIR384 NA
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 140)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0524 Tan Xiang檀香 SandalwoodSantalum album
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H1219 Hua Sheng Mi花生米 NAArachis hypogaea
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H1160 Han Xin Cao韩信草 Indian skullcapScutellaria indica
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0247 Mi Meng Hua密蒙花 Pale butterflybushBuddleja officinalis
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0727 Ye Gan Cao野甘草 Sweet broomwortScoparia dulcis
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H1218 Hua Sheng花生 NAArachis hypogaea
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1021 E Da Xia莪大夏 NAOxytropis falcata
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0204 Ma Ren麻仁 NACannabis sativa
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0010 Ji Guan Hua鸡冠花 Common cockscomb flowerCelosia cristata
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0730 Ye Ma Zhui野马追 NAEupatorium lindleyanum
H0183 Luo Hua Sheng Zhi Ye落花生枝叶 Peanut branch-leafArachis hypogaea
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii