Target Description

Type Detail
Target ID T90SGJ
Protein Name Caspase-2
Uniprot ID P42575
Protein Name Alias CASP-2;  EC 3.4.22.55;  Neural precursor cell expressed developmentally down-regulated protein 2;  NEDD-2;  Protease ICH-1
Gene ID 835
Gene Symbol CASP2
Gene Alias ICH1;  NEDD2
TTD T09128: Patented target
Pfam PF00619
GO
0005634:nucleus

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0003407:neural retina development

0005829:cytosol

0016020:membrane

0097190:apoptotic signaling pathway

0004197:cysteine-type endopeptidase activity

0001554:luteolysis

0016485:protein processing

0043066:negative regulation of apoptotic process

0042802:identical protein binding

0019899:enzyme binding

0035234:ectopic germ cell programmed cell death

0097153:cysteine-type endopeptidase activity involved in apoptotic process

0007420:brain development

0005737:cytoplasm

0006915:apoptotic process

0097192:extrinsic apoptotic signaling pathway in absence of ligand

0097200:cysteine-type endopeptidase activity involved in execution phase of apoptosis

0043065:positive regulation of apoptotic process

0097194:execution phase of apoptosis

0097199:cysteine-type endopeptidase activity involved in apoptotic signaling pathway

0043525:positive regulation of neuron apoptotic process

0042981:regulation of apoptotic process

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

2001235:positive regulation of apoptotic signaling pathway

0019904:protein domain specific binding

0071260:cellular response to mechanical stimulus

0007568:aging

0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

0005739:mitochondrion

PDB 6GKG ; 3R6G ; 3R7B ; 3R7N ; 3RJM ; 6GKF ; 6Y8D ; 1PYO ; 3R7S ; 6SAD ; 2P2C ; 6S9K ; 6Y8B ; 3R5J ; 3R6L
Drugbank NA
KEGG hsa:835

Related Compounds  (Total: 3)

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C0077
Name: Flavone
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C1019
Name: Atropine
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C1115
Name: cocaine


Related Herbs  (Total: 17)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0550 Tie Bang Chui Ye铁棒锤叶 Leaf of pendulous monkshoodFolium aconiti szechenyiani
H0667 Xiao Qing Pi小青皮 Green tangerine peelPericarpium citri reticulatae viride
H0222 Man Tuo Luo曼陀罗 JimsonweedDatura stramonium
H0223 Man Tuo Luo Jin Gao曼陀罗浸膏 JimsonweedDatura stramonium
H0347 Qing Pi青皮 Green tangerine peelPericarpium citri reticulatae viride
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0976 Di Qing Pi地青皮 NAPericarpium citri reticulatae viride
H0078 Jiu Bi Ying救必应 Ovateleaf hollyIlex rotunda
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H0700 Ya Zhi Cao鸭跖草 Common dayflowerCommelina communis
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0863 Zui Xian Tao醉仙桃 jimsonweedDatura stramonium
H0820 Chong Lou重楼 Paris rootRhizoma paridis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0388 San Ye Qing三叶青 Hemsley rockvine rootRadix tetrastigmatis hemsleyani
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1041 Feng Qie Hua枫茄花 JimsonweedDatura stramonium