HIT-result

Target Description

Type	Detail
Target ID	T52ARL
Protein Name	Suppressor of cytokine signaling 3
Uniprot ID	O14543
Protein Name Alias	SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3
Gene ID	9021
Gene Symbol	SOCS3
Gene Alias	CIS3; SSI3
TTD	T92477: Research target
Pfam	PF00017
GO	0016567:protein ubiquitination 0035556:intracellular signal transduction 0042532:negative regulation of tyrosine phosphorylation of STAT protein 0070102:interleukin-6-mediated signaling pathway 0046426:negative regulation of receptor signaling pathway via JAK-STAT 0046935:1-phosphatidylinositol-3-kinase regulator activity 0046627:negative regulation of insulin receptor signaling pathway 0060670:branching involved in labyrinthine layer morphogenesis 0046854:phosphatidylinositol phosphorylation 0005829:cytosol 0060334:regulation of interferon-gamma-mediated signaling pathway 0060708:spongiotrophoblast differentiation 0007259:receptor signaling pathway via JAK-STAT 0005942:phosphatidylinositol 3-kinase complex 0001784:phosphotyrosine residue binding 0050728:negative regulation of inflammatory response 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0004860:protein kinase inhibitor activity 0060674:placenta blood vessel development 0045597:positive regulation of cell differentiation 0060707:trophoblast giant cell differentiation 0019221:cytokine-mediated signaling pathway 1990830:cellular response to leukemia inhibitory factor 0040008:regulation of growth 0043687:post-translational protein modification 0043066:negative regulation of apoptotic process
PDB	NA
Drugbank	NA
KEGG	hsa:9021

Type

Detail

Target ID

T52ARL

Protein Name

Suppressor of cytokine signaling 3

Uniprot ID

O14543

Protein Name Alias

SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3

Gene ID

9021

Gene Symbol

SOCS3

Gene Alias

CIS3; SSI3

TTD

T92477: Research target

Pfam

PF00017

0016567:protein ubiquitination

0035556:intracellular signal transduction

0042532:negative regulation of tyrosine phosphorylation of STAT protein

0070102:interleukin-6-mediated signaling pathway

0046426:negative regulation of receptor signaling pathway via JAK-STAT

0046935:1-phosphatidylinositol-3-kinase regulator activity

0046627:negative regulation of insulin receptor signaling pathway

0060670:branching involved in labyrinthine layer morphogenesis

0046854:phosphatidylinositol phosphorylation

0005829:cytosol

0060334:regulation of interferon-gamma-mediated signaling pathway

0060708:spongiotrophoblast differentiation

0007259:receptor signaling pathway via JAK-STAT

0005942:phosphatidylinositol 3-kinase complex

0001784:phosphotyrosine residue binding

0050728:negative regulation of inflammatory response

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0004860:protein kinase inhibitor activity

0060674:placenta blood vessel development

0045597:positive regulation of cell differentiation

0060707:trophoblast giant cell differentiation

0019221:cytokine-mediated signaling pathway

1990830:cellular response to leukemia inhibitory factor

0040008:regulation of growth

0043687:post-translational protein modification

0043066:negative regulation of apoptotic process

PDB

Drugbank

KEGG

hsa:9021

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0388	San Ye Qing	三叶青	Hemsley rockvine root	Radix tetrastigmatis hemsleyani
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1162	Hang Shao	杭芍	White peony root	Paeonia albiflora
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0550	Tie Bang Chui Ye	铁棒锤叶	Leaf of pendulous monkshood	Folium aconiti szechenyiani
H0976	Di Qing Pi	地青皮	NA	Pericarpium citri reticulatae viride
H0078	Jiu Bi Ying	救必应	Ovateleaf holly	Ilex rotunda
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0700	Ya Zhi Cao	鸭跖草	Common dayflower	Commelina communis
H0023	Bai Shao Gan Jin Gao	白芍干浸膏	Common peony	Paeonia lactiflora
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H1036	Fen Dan Pi	粉丹皮	Tree peony bark	Paeonia suffruticosa
H0347	Qing Pi	青皮	Green tangerine peel	Pericarpium citri reticulatae viride
H0021	Bai Shao	白芍	Common peony	Paeonia lactiflora
H0667	Xiao Qing Pi	小青皮	Green tangerine peel	Pericarpium citri reticulatae viride
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0820	Chong Lou	重楼	Paris root	Rhizoma paridis
H0695	Ya Dan Zi	鸦胆子	Java brucea	Brucea javanica

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 27)