Target Description

Type Detail
Target ID T77PFO
Protein Name Histone deacetylase 6
Uniprot ID Q9UBN7
Protein Name Alias HD6;  EC 3.5.1.98;  Tubulin-lysine deacetylase HDAC6;  EC 3.5.1.-
Gene ID 10013
Gene Symbol HDAC6
Gene Alias KIAA0901
TTD T22274: Clinical Trial target
Pfam PF00850 ; PF02148
GO
0048668:collateral sprouting

0010727:negative regulation of hydrogen peroxide metabolic process

0016575:histone deacetylation

0006515:protein quality control for misfolded or incompletely synthesized proteins

1903146:regulation of autophagy of mitochondrion

0016241:regulation of macroautophagy

0045861:negative regulation of proteolysis

0051787:misfolded protein binding

0040029:regulation of gene expression, epigenetic

0007026:negative regulation of microtubule depolymerization

0016235:aggresome

0045598:regulation of fat cell differentiation

0090042:tubulin deacetylation

0010634:positive regulation of epithelial cell migration

0048487:beta-tubulin binding

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0004407:histone deacetylase activity

0071218:cellular response to misfolded protein

0031593:polyubiquitin modification-dependent protein binding

0061734:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

0030425:dendrite

0060765:regulation of androgen receptor signaling pathway

0031252:cell leading edge

0060271:cilium assembly

0035973:aggrephagy

0019899:enzyme binding

0043014:alpha-tubulin binding

0048471:perinuclear region of cytoplasm

0042903:tubulin deacetylase activity

0060632:regulation of microtubule-based movement

0006886:intracellular protein transport

0042826:histone deacetylase binding

0030424:axon

0031648:protein destabilization

0031647:regulation of protein stability

0048156:tau protein binding

0000209:protein polyubiquitination

0005875:microtubule associated complex

0008013:beta-catenin binding

1901300:positive regulation of hydrogen peroxide-mediated programmed cell death

0016234:inclusion body

0031625:ubiquitin protein ligase binding

0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)

0070301:cellular response to hydrogen peroxide

0033138:positive regulation of peptidyl-serine phosphorylation

0033558:protein deacetylase activity

0060997:dendritic spine morphogenesis

0005874:microtubule

0032984:protein-containing complex disassembly

0005654:nucleoplasm

0070840:dynein complex binding

0008270:zinc ion binding

0005771:multivesicular body

0005634:nucleus

0005901:caveola

0051879:Hsp90 protein binding

0003779:actin binding

0070842:aggresome assembly

0043242:negative regulation of protein-containing complex disassembly

0008017:microtubule binding

0010506:regulation of autophagy

0043162:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

0051354:negative regulation of oxidoreductase activity

0043130:ubiquitin binding

0034983:peptidyl-lysine deacetylation

0070201:regulation of establishment of protein localization

0001226:RNA polymerase II transcription corepressor binding

0005829:cytosol

0070846:Hsp90 deacetylation

0032418:lysosome localization

0051646:mitochondrion localization

0051788:response to misfolded protein

0043204:perikaryon

0005737:cytoplasm

0006476:protein deacetylation

0070848:response to growth factor

0031333:negative regulation of protein-containing complex assembly

0035967:cellular response to topologically incorrect protein

0000118:histone deacetylase complex

0070845:polyubiquitinated misfolded protein transport

0045892:negative regulation of transcription, DNA-templated

2000273:positive regulation of signaling receptor activity

PDB 3GV4 ; 6CE8 ; 5EDU ; 5B8D ; 5WPB ; 5KH7 ; 5KH3 ; 6CE6 ; 6CEE ; 6CED ; 3PHD ; 6CEA ; 5WBN ; 3C5K ; 6CEC ; 5KH9 ; 6CEF
Drugbank DB13346 ; DB05223 ; DB02546 ; DB06603 ; DB06176 ; DB05015
KEGG hsa:10013

Related Compounds  (Total: 5)

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C0101
Name: Genistein
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C0247
Name: Nicotine
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C0416
Name: Stearic Acid
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C0551
Name: P-Hydroxybenzoic Acid
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C0612
Name: Crotonoside


Related Herbs  (Total: 221)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H0364 Rou Cong Rong肉苁蓉 Desertliving cistancheCistanche deserticola
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0054 Jin Niu Cao金牛草 NAPolygala glomerata
H1227 Huai Zhi槐枝 NASophora japonica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H1202 Hu Huang Lian胡黄连 PicrorhizaPicrorhiza kurrooa
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0399 Sha Ren Ye砂仁叶 NAAmomum villosum
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0557 Ting Li Cao葶苈草 Descurainia sophiaLepidium apetalum
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0514 Cang Er Cao苍耳草 Cocklebur grassXanthium sibiricum
H0331 Qiang Huo羌活 Incised notopterygiumNotopterygium incisum
H0576 Tu Mu Xiang土木香 Elecampane inulaInula helenium
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H1156 Ai Di Huang矮地黄 RehmanniaeRehmannia glutinosa
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0317 Pu Huang Jin Gao蒲黄浸膏 Typha angustifoliaTypha angustata
H0509 Cang Er苍耳 Siberian cockleburXanthium sibiricum
H0456 Bu Gu Zhi补骨脂 Malaytea scurfpeaPsoralea corylifolia
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0843 Zi Bei Mu紫贝母 NAFritillaria unibracteata
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0751 Yin Yang Huo淫羊藿 NAEpimedium brevicornum
H0357 Ren Shen人参 GinsengPanax ginseng
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0079 Jiu Cai韭菜 Tuber onionAllium tuberosum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1201 Hu Er Cao虎耳草 Creeping rockfoilSaxifraga stolonifera
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0910 Ci Wu Jia Jin Gao刺五加浸膏 Manypr ickle acanthopana xEleutherococcus senticosus
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1007 Dou You豆油 Soybean oilGlycine max
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0913 Ci Wu Jia Qing Gao刺五加清膏 Manypr ickle acanthopana xEleutherococcus senticosus
H0753 Yin Yang Huo Jin Gao淫羊藿浸膏 Epimedium sagittatumEpimedium brevicornum
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0908 Ci Wu Jia刺五加 Manypr ickle acanthopana xEleutherococcus senticosus
H0973 Di Huang Tan地黄炭 RehmanniaeRehmannia glutinosa
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0134 Li Zhi He荔枝核 Lychee seedLitchi chinensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0909 Ci Wu Jia Gao刺五加膏 Manypr ickle acanthopana xEleutherococcus senticosus
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0558 Ting Li Zi葶苈子 Descurainia sophiaLepidium apetalum
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H1079 Gan Di Huang干地黄 Adhesive rehmannia dried rootRehmannia glutinosa
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0316 Pu Huang蒲黄 Typha angustifoliaTypha angustata
H0476 Can E蚕蛾 SilkwormBombyx mori
H0912 Ci Wu Jia Jin Yu刺五加浸育 Manypr ickle acanthopana xEleutherococcus senticosus
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0771 Yuan Zhi Liu Jin Gao远志流浸膏 Thinleaf milkwortPolygala tenuifolia
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0416 Shan Shen山参 NAPanax ginseng
H0352 Quan Xie全蝎 ScorpionButhus martensi
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0249 Bei Ting Li Zi北葶苈子 Descurainia sophiaLepidium apetalum
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0026 Jiang Soybean pasteGlycine max
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0752 Yin Yang Huo Gan Gao Fen淫羊藿干膏粉 Epimedium sagittatumEpimedium brevicornum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0627 Xi Xian豨莶 Common st paulswortSiegesbeckia orientalis
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0597 Wu Jia Pi五加皮 Slenderstyle acanthopanax root-barkAcanthopanax gracilistylus
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0279 Nan Gua南瓜 CushawCucurbita moschata
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H0473 Shu Di Huang熟地黄 Adhesive rehmannia cocked rootRehmannia glutinosa
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0695 Ya Dan Zi鸦胆子 Java bruceaBrucea javanica
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0144 Ban Li Ke板栗壳 Chestnut shellCastanea mollissima
H0573 Tu Jia Pi土加皮 NAAcanthopanax gracilistylus
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H1225 Huai Mi槐米 NASophora japonica
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0881 Chuan Qiang Huo川羌活 Incised notopterygiumNotopterygium incisum
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0255 Mao Zhao Cao猫爪草 Root of catclaw buttercupRanunculus ternatus
H0769 Yuan Zhi远志 Thinleaf milkwortPolygala tenuifolia
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0204 Ma Ren麻仁 NACannabis sativa
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0631 Xi Yang Shen西洋参 American ginsengPanax quinquefolium
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0686 Xuan Fu Hua旋覆花 Inula flowerFlos inulae
H0584 Tu Wu Jia土五加 NAAcanthopanax gracilistylus
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0535 Teng Wu Jia Gen藤五加根 NAAcanthopanax gracilistylus
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H1110 Gua Lou Zi瓜蒌子 mongolian snakegourd seedTrichosanthes kirilowii maxim
H0972 Di Huang地黄 RehmanniaeRehmannia glutinosa
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0398 Sha Ren砂仁 Villous amomumAmomum villosum
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H0770 Yuan Zhi Jin Gao远志浸膏 Thinleaf milkwortPolygala tenuifolia
H0086 Jiu Zi韭子 Tuber onion seedAllium tuberosum
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis