Target Description

Type Detail
Target ID T17E49
Protein Name Cannabinoid receptor 1
Uniprot ID P21554
Protein Name Alias CB-R;  CB1;  CANN6
Gene ID 1268
Gene Symbol CNR1
Gene Alias CNR
TTD T76685: Successful target
Pfam PF00001
GO
0005741:mitochondrial outer membrane

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway

0050796:regulation of insulin secretion

0002866:positive regulation of acute inflammatory response to antigenic stimulus

0098921:retrograde trans-synaptic signaling by endocannabinoid

0010976:positive regulation of neuron projection development

0042593:glucose homeostasis

0060135:maternal process involved in female pregnancy

0031999:negative regulation of fatty acid beta-oxidation

0098982:GABA-ergic synapse

0098978:glutamatergic synapse

0032496:response to lipopolysaccharide

0045759:negative regulation of action potential

0099553:trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

0099056:integral component of presynaptic membrane

0042802:identical protein binding

0014063:negative regulation of serotonin secretion

0008144:drug binding

0051966:regulation of synaptic transmission, glutamatergic

0007283:spermatogenesis

0019233:sensory perception of pain

0033602:negative regulation of dopamine secretion

0015629:actin cytoskeleton

0045121:membrane raft

0043278:response to morphine

0045776:negative regulation of blood pressure

0045471:response to ethanol

0004949:cannabinoid receptor activity

0043065:positive regulation of apoptotic process

0004930:G protein-coupled receptor activity

0045777:positive regulation of blood pressure

0042220:response to cocaine

0035094:response to nicotine

0030426:growth cone

0007613:memory

0005886:plasma membrane

0007413:axonal fasciculation

0033004:negative regulation of mast cell activation

0032228:regulation of synaptic transmission, GABAergic

0007186:G protein-coupled receptor signaling pathway

0051001:negative regulation of nitric-oxide synthase activity

0019222:regulation of metabolic process

0005887:integral component of plasma membrane

0038171:cannabinoid signaling pathway

0007584:response to nutrient

0007568:aging

0032592:integral component of mitochondrial membrane

0031622:positive regulation of fever generation

0060405:regulation of penile erection

0005737:cytoplasm

0060259:regulation of feeding behavior

0099635:voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

PDB 6KPG ; 6KQI ; 1LVR ; 1LVQ ; 6N4B ; 2KOE ; 5TGZ ; 2MZ2 ; 5XR8 ; 2MZ3 ; 2MZA ; 5XRA ; 2B0Y ; 5U09
Drugbank DB09288 ; DB02955 ; DB06155 ; DB00486 ; DB00470 ; DB11745 ; DB14011 ; DB09061 ; DB14009 ; DB05201 ; DB11755 ; DB05750 ; DB05077
KEGG hsa:1268

Related Compounds  (Total: 14)

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C0035
Name: Dronabinol
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C0088
Name: Gabapentin
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C0226
Name: Morphine
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C0261
Name: Oleamide
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C0299
Name: Phenethylamine


Related Herbs  (Total: 49)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1191 Hong Shen红参 Red ginsengRadix ginseng rubra
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0416 Shan Shen山参 NAPanax ginseng
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0378 San Qi三七 SanchiPanax notoginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0204 Ma Ren麻仁 NACannabis sativa
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0736 Yi Dian Hong一点红 Sowthistle tasselflowerEmilia sonchifolia
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0938 Da Suan大蒜 GarlicAllium sativum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0849 Zi Su Geng紫苏梗 Common perilla stemPerilla frutescens var. arguta
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0943 Dan Cai淡菜 MusselMytilus edulis
H0357 Ren Shen人参 GinsengPanax ginseng
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H1030 Fang Feng防风 Divaricate saposhnikoviaSaposhnikovia divaricata
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0850 Zi Su Ye紫苏叶 Common perilla leafPerilla frutescens var. arguta
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis