HIT-result

Target Description

Type	Detail
Target ID	T46PRA
Protein Name	Excitatory amino acid transporter 3
Uniprot ID	P43005
Protein Name Alias	Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
Gene ID	6505
Gene Symbol	SLC1A1
Gene Alias	EAAC1; EAAT3
TTD	T31721: Research target
Pfam	PF00375
GO	0098877:neurotransmitter receptor transport to plasma membrane 0010842:retina layer formation 0007215:glutamate receptor signaling pathway 0001975:response to amphetamine 0018105:peptidyl-serine phosphorylation 0071407:cellular response to organic cyclic compound 0005783:endoplasmic reticulum 0016021:integral component of membrane 0150104:transport across blood-brain barrier 0031902:late endosome membrane 0043197:dendritic spine 0098712:L-glutamate import across plasma membrane 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0043278:response to morphine 0051938:L-glutamate import 0030424:axon 0043198:dendritic shaft 0005313:L-glutamate transmembrane transporter activity 0033229:cysteine transmembrane transporter activity 0060047:heart contraction 0010460:positive regulation of heart rate 0042802:identical protein binding 1990708:conditioned place preference 0006836:neurotransmitter transport 0070777:D-aspartate transport 0005314:high-affinity glutamate transmembrane transporter activity 0035633:maintenance of blood-brain barrier 0016324:apical plasma membrane 0061744:motor behavior 0007626:locomotory behavior 0015108:chloride transmembrane transporter activity 0032148:activation of protein kinase B activity 0001662:behavioral fear response 0005887:integral component of plasma membrane 0071288:cellular response to mercury ion 0005253:anion channel activity 0045121:membrane raft 0048514:blood vessel morphogenesis 0055038:recycling endosome membrane 0031901:early endosome membrane 0015183:L-aspartate transmembrane transporter activity 0090461:glutamate homeostasis 0042417:dopamine metabolic process 0043083:synaptic cleft 0006882:cellular zinc ion homeostasis 0046872:metal ion binding 0140009:L-aspartate import across plasma membrane 1990635:proximal dendrite 0090313:regulation of protein targeting to membrane 0048678:response to axon injury 0098793:presynapse 0006811:ion transport 0043524:negative regulation of neuron apoptotic process 0007268:chemical synaptic transmission 0009986:cell surface 0016595:glutamate binding 0015501:glutamate:sodium symporter activity 0140010:D-aspartate transmembrane transporter activity 0071242:cellular response to ammonium ion 0072347:response to anesthetic 0032279:asymmetric synapse 0043204:perikaryon 0016020:membrane 0070633:transepithelial transport 0007625:grooming behavior 1902476:chloride transmembrane transport 0036293:response to decreased oxygen levels 0070778:L-aspartate transmembrane transport 0036475:neuron death in response to oxidative stress 0070062:extracellular exosome 0030425:dendrite 0015813:L-glutamate transmembrane transport 0097386:glial cell projection 0097049:motor neuron apoptotic process 0071944:cell periphery 0042883:cysteine transport 0097440:apical dendrite 0099544:perisynaptic space 0005886:plasma membrane 0150002:distal dendrite 0007212:dopamine receptor signaling pathway 0010467:gene expression 0006750:glutathione biosynthetic process 0060291:long-term synaptic potentiation 0070779:D-aspartate import across plasma membrane 0022008:neurogenesis 0043025:neuronal cell body 0043679:axon terminus 0060013:righting reflex
PDB	6S3Q
Drugbank	DB00128 ; DB00142 ; DB00230
KEGG	hsa:6505

Type

Detail

Target ID

T46PRA

Protein Name

Excitatory amino acid transporter 3

Uniprot ID

P43005

Protein Name Alias

Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1

Gene ID

6505

Gene Symbol

SLC1A1

Gene Alias

EAAC1; EAAT3

TTD

T31721: Research target

Pfam

PF00375

0098877:neurotransmitter receptor transport to plasma membrane

0010842:retina layer formation

0007215:glutamate receptor signaling pathway

0001975:response to amphetamine

0018105:peptidyl-serine phosphorylation

0071407:cellular response to organic cyclic compound

0005783:endoplasmic reticulum

0016021:integral component of membrane

0150104:transport across blood-brain barrier

0031902:late endosome membrane

0043197:dendritic spine

0098712:L-glutamate import across plasma membrane

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0043278:response to morphine

0051938:L-glutamate import

0030424:axon

0043198:dendritic shaft

0005313:L-glutamate transmembrane transporter activity

0033229:cysteine transmembrane transporter activity

0060047:heart contraction

0010460:positive regulation of heart rate

0042802:identical protein binding

1990708:conditioned place preference

0006836:neurotransmitter transport

0070777:D-aspartate transport

0005314:high-affinity glutamate transmembrane transporter activity

0035633:maintenance of blood-brain barrier

0016324:apical plasma membrane

0061744:motor behavior

0007626:locomotory behavior

0015108:chloride transmembrane transporter activity

0032148:activation of protein kinase B activity

0001662:behavioral fear response

0005887:integral component of plasma membrane

0071288:cellular response to mercury ion

0005253:anion channel activity

0045121:membrane raft

0048514:blood vessel morphogenesis

0055038:recycling endosome membrane

0031901:early endosome membrane

0015183:L-aspartate transmembrane transporter activity

0090461:glutamate homeostasis

0042417:dopamine metabolic process

0043083:synaptic cleft

0006882:cellular zinc ion homeostasis

0046872:metal ion binding

0140009:L-aspartate import across plasma membrane

1990635:proximal dendrite

0090313:regulation of protein targeting to membrane

0048678:response to axon injury

0098793:presynapse

0006811:ion transport

0043524:negative regulation of neuron apoptotic process

0007268:chemical synaptic transmission

0009986:cell surface

0016595:glutamate binding

0015501:glutamate:sodium symporter activity

0140010:D-aspartate transmembrane transporter activity

0071242:cellular response to ammonium ion

0072347:response to anesthetic

0032279:asymmetric synapse

0043204:perikaryon

0016020:membrane

0070633:transepithelial transport

0007625:grooming behavior

1902476:chloride transmembrane transport

0036293:response to decreased oxygen levels

0070778:L-aspartate transmembrane transport

0036475:neuron death in response to oxidative stress

0070062:extracellular exosome

0030425:dendrite

0015813:L-glutamate transmembrane transport

0097386:glial cell projection

0097049:motor neuron apoptotic process

0071944:cell periphery

0042883:cysteine transport

0097440:apical dendrite

0099544:perisynaptic space

0005886:plasma membrane

0150002:distal dendrite

0007212:dopamine receptor signaling pathway

0010467:gene expression

0006750:glutathione biosynthetic process

0060291:long-term synaptic potentiation

0070779:D-aspartate import across plasma membrane

0022008:neurogenesis

0043025:neuronal cell body

0043679:axon terminus

0060013:righting reflex

PDB

6S3Q

Drugbank

DB00128 ; DB00142 ; DB00230

KEGG

hsa:6505

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0077	Jiu	酒	Ethanol	Vinum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 29)