HIT-result

Target Description

Type	Detail
Target ID	T08OEP
Protein Name	Monocyte differentiation antigen CD14
Uniprot ID	P08571
Protein Name Alias	Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14
Gene ID	929
Gene Symbol	CD14
Gene Alias	NA
TTD	T23212: Clinical Trial target
Pfam	NA
GO	0070062:extracellular exosome 0002755:MyD88-dependent toll-like receptor signaling pathway 0005615:extracellular space 0030667:secretory granule membrane 0016019:peptidoglycan immune receptor activity 0001847:opsonin receptor activity 0070266:necroptotic process 0097190:apoptotic signaling pathway 1901224:positive regulation of NIK/NF-kappaB signaling 0031663:lipopolysaccharide-mediated signaling pathway 0032760:positive regulation of tumor necrosis factor production 0071723:lipopeptide binding 0032757:positive regulation of interleukin-8 production 0038123:toll-like receptor TLR1:TLR2 signaling pathway 0035666:TRIF-dependent toll-like receptor signaling pathway 0071726:cellular response to diacyl bacterial lipopeptide 0009897:external side of plasma membrane 0005576:extracellular region 0046696:lipopolysaccharide receptor complex 0032729:positive regulation of interferon-gamma production 0034142:toll-like receptor 4 signaling pathway 0007166:cell surface receptor signaling pathway 0032481:positive regulation of type I interferon production 0006915:apoptotic process 0005794:Golgi apparatus 0005886:plasma membrane 0006898:receptor-mediated endocytosis 0001530:lipopolysaccharide binding 0009408:response to heat 0071219:cellular response to molecule of bacterial origin 0045087:innate immune response 0071727:cellular response to triacyl bacterial lipopeptide 0034128:negative regulation of MyD88-independent toll-like receptor signaling pathway 0034612:response to tumor necrosis factor 0045807:positive regulation of endocytosis 0032026:response to magnesium ion 0007249:I-kappaB kinase/NF-kappaB signaling 0043312:neutrophil degranulation 0071222:cellular response to lipopolysaccharide 0010008:endosome membrane 0002224:toll-like receptor signaling pathway 0031362:anchored component of external side of plasma membrane 0045121:membrane raft 0038124:toll-like receptor TLR6:TLR2 signaling pathway 0070891:lipoteichoic acid binding 0006954:inflammatory response 0045471:response to ethanol 0071223:cellular response to lipoteichoic acid 0051602:response to electrical stimulus 0006909:phagocytosis 0002756:MyD88-independent toll-like receptor signaling pathway
PDB	4GLP
Drugbank	NA
KEGG	hsa:929

Type

Detail

Target ID

T08OEP

Protein Name

Monocyte differentiation antigen CD14

Uniprot ID

P08571

Protein Name Alias

Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14

Gene ID

929

Gene Symbol

CD14

Gene Alias

TTD

T23212: Clinical Trial target

Pfam

0070062:extracellular exosome

0002755:MyD88-dependent toll-like receptor signaling pathway

0005615:extracellular space

0030667:secretory granule membrane

0016019:peptidoglycan immune receptor activity

0001847:opsonin receptor activity

0070266:necroptotic process

0097190:apoptotic signaling pathway

1901224:positive regulation of NIK/NF-kappaB signaling

0031663:lipopolysaccharide-mediated signaling pathway

0032760:positive regulation of tumor necrosis factor production

0071723:lipopeptide binding

0032757:positive regulation of interleukin-8 production

0038123:toll-like receptor TLR1:TLR2 signaling pathway

0035666:TRIF-dependent toll-like receptor signaling pathway

0071726:cellular response to diacyl bacterial lipopeptide

0009897:external side of plasma membrane

0005576:extracellular region

0046696:lipopolysaccharide receptor complex

0032729:positive regulation of interferon-gamma production

0034142:toll-like receptor 4 signaling pathway

0007166:cell surface receptor signaling pathway

0032481:positive regulation of type I interferon production

0006915:apoptotic process

0005794:Golgi apparatus

0005886:plasma membrane

0006898:receptor-mediated endocytosis

0001530:lipopolysaccharide binding

0009408:response to heat

0071219:cellular response to molecule of bacterial origin

0045087:innate immune response

0071727:cellular response to triacyl bacterial lipopeptide

0034128:negative regulation of MyD88-independent toll-like receptor signaling pathway

0034612:response to tumor necrosis factor

0045807:positive regulation of endocytosis

0032026:response to magnesium ion

0007249:I-kappaB kinase/NF-kappaB signaling

0043312:neutrophil degranulation

0071222:cellular response to lipopolysaccharide

0010008:endosome membrane

0002224:toll-like receptor signaling pathway

0031362:anchored component of external side of plasma membrane

0045121:membrane raft

0038124:toll-like receptor TLR6:TLR2 signaling pathway

0070891:lipoteichoic acid binding

0006954:inflammatory response

0045471:response to ethanol

0071223:cellular response to lipoteichoic acid

0051602:response to electrical stimulus

0006909:phagocytosis

0002756:MyD88-independent toll-like receptor signaling pathway

PDB

4GLP

Drugbank

KEGG

hsa:929

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0590	Wei Ling	威灵	Chinese clematis	Clematis chinensis
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum
H0832	Zhu Sha Gen	朱砂根	Coral ardisia	Ardisia crenata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0848	Zi Jin Niu	紫金牛	Japanese ardisia	Ardisia japonica
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0592	Wei Ling Xian	威灵仙	Chinese clematis	Clematis chinensis
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H0329	Qian Niu Zi	牵牛子	Lobedleaf pharbitis seed	Pharbitis nil
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 23)