HIT-result

Type	Detail
Target ID	T13WH4
Protein Name	Interferon-induced, double-stranded RNA-activated protein kinase
Uniprot ID	P19525
Protein Name Alias	EC 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated; PKR; Protein kinase R; Tyrosine-protein kinase EIF2AK2; EC 2.7.10.2; p68 kinase
Gene ID	5610
Gene Symbol	EIF2AK2
Gene Alias	PKR; PRKR
TTD	T04831: Patented target
Pfam	PF00035 ; PF00069
GO	0042802:identical protein binding 0005634:nucleus 0046777:protein autophosphorylation 0051607:defense response to virus 0004672:protein kinase activity 0032874:positive regulation of stress-activated MAPK cascade 0106310:protein serine kinase activity 0033689:negative regulation of osteoblast proliferation 0017148:negative regulation of translation 0005829:cytosol 0004674:protein serine/threonine kinase activity 1901224:positive regulation of NIK/NF-kappaB signaling 0106311:protein threonine kinase activity 1901532:regulation of hematopoietic progenitor cell differentiation 0004694:eukaryotic translation initiation factor 2alpha kinase activity 0008285:negative regulation of cell population proliferation 0051092:positive regulation of NF-kappaB transcription factor activity 0003725:double-stranded RNA binding 0032722:positive regulation of chemokine production 0005524:ATP binding 1902033:regulation of hematopoietic stem cell proliferation 0048471:perinuclear region of cytoplasm 0019888:protein phosphatase regulator activity 0034198:cellular response to amino acid starvation 0005840:ribosome 0016020:membrane 0003723:RNA binding 0009615:response to virus 0004715:non-membrane spanning protein tyrosine kinase activity 0001819:positive regulation of cytokine production 0006468:protein phosphorylation 0035455:response to interferon-alpha 0004714:transmembrane receptor protein tyrosine kinase activity 0005737:cytoplasm 0045071:negative regulation of viral genome replication 0000186:activation of MAPKK activity 0030683:mitigation of host immune response by virus 1900225:regulation of NLRP3 inflammasome complex assembly 0045087:innate immune response 1902036:regulation of hematopoietic stem cell differentiation
PDB	3UIU ; 6D3L ; 2A19 ; 2A1A ; 1QU6 ; 6D3K
Drugbank	DB12010
KEGG	hsa:5610

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0743	Yi Zhi Ren	益智仁	Sharpleaf galangal	Alpinia oxyphylla
H0613	Wu Yue Ai	五月艾	Artemisia	Artemisia princeps
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0188	Lv Cao	葎草	Japanese hop	Humulus japonicus
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0924	Da Fu Pi	大腹皮	pericarp of betelnutpalm	Pericarpium arecae
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H0126	Lai Fu Zi	莱菔子	Garden radish seed	Raphanus sativus
H0897	Chuan Lian	川楝	Chinaberry	Melia azedarach
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H1107	Gua Lou Ren Shuang	瓜蒌仁霜	NA	Trichosanthes kirilowii
H0631	Xi Yang Shen	西洋参	American ginseng	Panax quinquefolium
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0998	Dong Gua Pi	冬瓜皮	Chinese waxgourd peel	Benincasa hispida
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H1130	Guang Zao	广枣	fruit of axillary choerospondias	Fructus choerospondiatis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0972	Di Huang	地黄	Rehmanniae	Rehmannia glutinosa
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0466	Cai Fu Zi	菜菔子	Semen raphani	Raphanus sativus
H0216	Man Jing Ye	蔓荆叶	Threeleaf chastetree leaf	Vitex trifolia
H1105	Gua Lou Pi	瓜蒌皮	NA	Trichosanthes kirilowii
H0887	Chuan Xin Lian Gan Jin Gao	穿心莲干浸膏	Common andrographis	Andrographis paniculata
H0109	Ku Lian Zi	苦楝子	NA	Melia azedarach
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H0327	Qian Li Guang	千里光	Climbing groundsel	Senecio scandens
H1188	Hong Hua	红花	Safflower	Carthamus tinctorius
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0519	Suo Yang	锁阳	Songaria cynomorium	Cynomorium songaricum
H0688	Xuan Shen	玄参	Ningpo figwort	Scrophularia ningpoensis
H0427	Shan Zhu Yu	山茱萸	Asiatic cornelian cherry	Cornus officinalis
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0889	Chuan Xin Lian Jin Gao	穿心莲浸膏	Common andrographis	Andrographis paniculata
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H1203	Hu Ji Sheng	槲寄生	Colored mistletoe	Viscum coloratum
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0402	Sha Yuan Zi	沙苑子	Flatstem milkvetch seed	Semen astragali complanati
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0085	Jiu Yu Rou	酒萸肉	Asiatic cornelian cherry	Cornus officinalis
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H1079	Gan Di Huang	干地黄	Adhesive rehmannia dried root	Rehmannia glutinosa
H0093	Ju Pi	橘皮	Tangerine pericarp	Citrus reticulata
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0108	Ku Lian Pi	苦楝皮	Chinaberry-tree bark	Melia azedarach
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0409	Shan Jiang	山姜	shell ginger	Alpinia zerumbet
H1229	Bai Mu Xiang	白木香	Chinese eaglewood	Aquilaria sinensis
H1106	Gua Lou Ren	瓜蒌仁	NA	Trichosanthes kirilowii
H0768	Yuan Shen	元参	Figwort root	Scrophularia ningpoensis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0886	Chuan Xin Lian	穿心莲	Common andrographis	Andrographis paniculata
H0134	Li Zhi He	荔枝核	Lychee seed	Litchi chinensis
H0524	Tan Xiang	檀香	Sandalwood	Santalum album
H1156	Ai Di Huang	矮地黄	Rehmanniae	Rehmannia glutinosa
H1232	Huang Cao Wu	黄草乌	NA	Aconitum vilmorinianum
H1000	Dong Gua Zi	冬瓜子	Chinese waxgourd seed	Benincasa hispida
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0973	Di Huang Tan	地黄炭	Rehmanniae	Rehmannia glutinosa
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0104	Bai Zhu	白术	Largehead atractylodes	Atractylodes macrocephala
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0169	Lou Lu	漏芦	Uniflower swisscentaury	Rhaponticum uniflorum
H0217	Man Jing Zi	蔓荆子	Threeleaf chastetree fruit	Vitex trifolia
H0401	Sha Yuan Ji Li	沙苑蒺藜	Seed of flaststem milkvetch	Semen astragali complanati
H0088	Ju He	橘核	Tangerine seed	Citrus reticulata
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0740	Yi Zhi	益智	Fructus alpinae oxyphyllae	Alpinia oxyphylla
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0890	Chuan Xin Lian Nong Suo Ye	穿心莲浓缩液	Common andrographis	Andrographis paniculata
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0561	Tong Ji Li	潼蒺藜	Flatstem milkvetch seed	Semen astragali complanati
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1110	Gua Lou Zi	瓜蒌子	mongolian snakegourd seed	Trichosanthes kirilowii maxim
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H1112	Gua Lou Ren(1)	栝楼仁	NA	Trichosanthes kirilowii
H1104	Gua Lou	瓜蒌	NA	Trichosanthes kirilowii
H0125	Lai Fu	莱菔	Garden radish	Raphanus sativus
H0679	Xing Ren	杏仁	Apricot seed	Prunus armeniaca
H1111	Gua Lou Gen	栝楼根	NA	Trichosanthes kirilowii
H1108	Gua Lou Shi	栝蒌实	NA	Trichosanthes kirilowii
H0416	Shan Shen	山参	NA	Panax ginseng
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0473	Shu Di Huang	熟地黄	Adhesive rehmannia cocked root	Rehmannia glutinosa
H0539	Tian Hua Fen	天花粉	Mongolian snakegourd root	Trichosanthes kirilowii
H0204	Ma Ren	麻仁	NA	Cannabis sativa

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 103)