Herb Description
| Herb ID: H0169 | Chinese Character: 漏芦 |
| English Name: Uniflower swisscentaury | Latin Name: Rhaponticum uniflorum |
| Chinese Pin Yin : Lou Lu | TCM-ID: TCMH1331 |
| Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
| Herb Function: Remove toxic heat for treating subcutaneous infections, promote lactation, and relieve muscular contracture | |
Related Targets (Total: 91)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
1 Reference(s) |
| T90ZKN | Cathepsin B | CTSB |
P07858 |
1 Reference(s) |
| T70OGQ | Sodium/potassium-transporting ATPase subunit alpha-1 | ATP1A1 |
P05023 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T73EVE | Cyclic AMP-dependent transcription factor ATF-2 | ATF2 |
P15336 |
1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
1 Reference(s) |
| T34FQX | Protein kinase C zeta type | PRKCZ |
Q05513 |
1 Reference(s) |
| T74QOR | Tyrosine-protein kinase JAK3 | JAK3 |
P52333 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
1 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
| T32KN9 | Alpha-amylase 1A | AMY1A |
P0DUB6 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
3 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
2 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
1 Reference(s) |
| T15I0F | Proteasome activator complex subunit 1 | PSME1 |
Q06323 |
1 Reference(s) |
| T44BWE | Adiponectin receptor protein 2 | ADIPOR2 |
Q86V24 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
4 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
7 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
3 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
3 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
1 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
2 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
2 Reference(s) |
| T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
6 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
4 Reference(s) |
| T39YUJ | Tyrosine-protein phosphatase non-receptor type 6 | PTPN6 |
P29350 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
5 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
2 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T95H9O | Stromelysin-2 | MMP10 |
P09238 |
1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
3 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
2 Reference(s) |
| T38OH4 | Caspase-1 | CASP1 |
P29466 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
2 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
2 Reference(s) |
| T08U92 | Mitochondrial brown fat uncoupling protein 1 | UCP1 |
P25874 |
1 Reference(s) |
| T13WH4 | Interferon-induced, double-stranded RNA-activated protein kinase | EIF2AK2 |
P19525 |
1 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
1 Reference(s) |
| T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
1 Reference(s) |
| T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
1 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
1 Reference(s) |
| T04UTZ | G1/S-specific cyclin-E1 | CCNE1 |
P24864 |
1 Reference(s) |
| T80OPZ | NADPH oxidase 4 | NOX4 |
Q9NPH5 |
1 Reference(s) |
| T53ES3 | Protein S100-A1 | S100A1 |
P23297 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
1 Reference(s) |
| T04A6O | UDP-glucuronosyltransferase 1A3 | UGT1A3 |
P35503 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
1 Reference(s) |
| T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
1 Reference(s) |
| T37WQE | Kallikrein-5 | KLK5 |
Q9Y337 |
1 Reference(s) |
| T16DCZ | Twist-related protein 1 | TWIST1 |
Q15672 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
1 Reference(s) |
| T94AGC | [F-actin]-monooxygenase MICAL1 | MICAL1 |
Q8TDZ2 |
1 Reference(s) |
| T48K08 | Procathepsin L | CTSL |
P07711 |
1 Reference(s) |
| T27S6H | Pulmonary surfactant-associated protein B | SFTPB |
P07988 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
1 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
1 Reference(s) |
| T19BO9 | Bone morphogenetic protein 4 | BMP4 |
P12644 |
1 Reference(s) |
| T34AW3 | Lipopolysaccharide-binding protein | LBP |
P18428 |
1 Reference(s) |
Related Compounds (Total: 3)
key description of the interaction between compound and target