Target Description

Type Detail
Target ID T39YUJ
Protein Name Tyrosine-protein phosphatase non-receptor type 6
Uniprot ID P29350
Protein Name Alias EC 3.1.3.48;  Hematopoietic cell protein-tyrosine phosphatase;  Protein-tyrosine phosphatase 1C;  PTP-1C;  Protein-tyrosine phosphatase SHP-1;  SH-PTP1
Gene ID 5777
Gene Symbol PTPN6
Gene Alias HCP;  PTP1C
TTD T98264: Patented target
Pfam PF00102 ; PF00017
GO
0005634:nucleus

0019221:cytokine-mediated signaling pathway

0005829:cytosol

1905867:epididymis development

0016020:membrane

0032991:protein-containing complex

0018108:peptidyl-tyrosine phosphorylation

0033630:positive regulation of cell adhesion mediated by integrin

0031295:T cell costimulation

0004725:protein tyrosine phosphatase activity

0071345:cellular response to cytokine stimulus

0042105:alpha-beta T cell receptor complex

0032720:negative regulation of tumor necrosis factor production

0002244:hematopoietic progenitor cell differentiation

0050732:negative regulation of peptidyl-tyrosine phosphorylation

0050860:negative regulation of T cell receptor signaling pathway

0070372:regulation of ERK1 and ERK2 cascade

0005654:nucleoplasm

0030154:cell differentiation

0001784:phosphotyrosine residue binding

0050900:leukocyte migration

0042130:negative regulation of T cell proliferation

0070527:platelet aggregation

0043407:negative regulation of MAP kinase activity

0030220:platelet formation

0070062:extracellular exosome

0035556:intracellular signal transduction

0008285:negative regulation of cell population proliferation

0002924:negative regulation of humoral immune response mediated by circulating immunoglobulin

0035335:peptidyl-tyrosine dephosphorylation

0005730:nucleolus

0050839:cell adhesion molecule binding

0032715:negative regulation of interleukin-6 production

0043312:neutrophil degranulation

0030168:platelet activation

0035855:megakaryocyte development

0005576:extracellular region

0050853:B cell receptor signaling pathway

0006470:protein dephosphorylation

0035580:specific granule lumen

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0042169:SH2 domain binding

0140031:phosphorylation-dependent protein binding

0007186:G protein-coupled receptor signaling pathway

0042981:regulation of apoptotic process

0051279:regulation of release of sequestered calcium ion into cytosol

1904724:tertiary granule lumen

0019901:protein kinase binding

2000045:regulation of G1/S transition of mitotic cell cycle

0008284:positive regulation of cell population proliferation

0045577:regulation of B cell differentiation

0005911:cell-cell junction

0017124:SH3 domain binding

0005737:cytoplasm

0060338:regulation of type I interferon-mediated signaling pathway

0033277:abortive mitotic cell cycle

0042267:natural killer cell mediated cytotoxicity

0005001:transmembrane receptor protein tyrosine phosphatase activity

PDB 2B3O ; 4HJP ; 4HJQ ; 1FPR ; 1X6C ; 3PS5 ; 1GWZ ; 6SM5 ; 2RMX ; 4GS0 ; 4GRZ ; 2YU7 ; 4GRY
Drugbank DB01133
KEGG hsa:5777

Related Compounds  (Total: 2)

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C0476
Name: Ursolic Acid
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C0490
Name: Zerumbone


Related Herbs  (Total: 102)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0854 Zi Wei Gen Pi紫葳根皮 NACampsis grandiflora
H1109 Bai Hua She She Cao白花蛇舌草 Spreading hedyitisOldenlandia diffusa
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H1049 Feng Xiang Zhi Chou Gao枫香脂稠膏 NALiquidambar formosana
H0177 Lu Lu Tong路路通 Beautiful sweetgumLiquidambar formosana
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0063 Jin Ye Zi金叶子 Yunnan craibiodendronCraibiodendron yunnanese
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H1047 Feng Xiang Ye枫香叶 NALiquidambar formosana
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0902 Chun Pi椿皮 Ailanthus bark, tree of heaven barkAilanthi cortex
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0591 Wei Ling Cai委陵菜 Chinese cinquefoilPotentilla chinensis
H0470 Shi Ye柿叶 Persimmon leafDiospyros kaki
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0646 Xiang Qing Lan香青兰 DragonheadDracocephalum moldavica
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0493 Shui Yang Mei水杨梅 Japanese avensGeum japonicum
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0701 Yan Bai岩柏 NAJuniperus formosana
H0963 Dao Kou Cao倒扣草 NAAchyranthes aspera
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H0728 Ye Jiang野姜 NAZingiber cassumunar
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0503 Song Jie松节 Knotty pine wood, pine nodular branchLignum pini nodi
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0453 Shi Di柿蒂 Persimmon persistent calyxDiospyros kaki
H0494 Shui Yang Mei Gen水杨梅根 Japanese avens rootGeum japonicum
H0801 Chong Bai La虫白蜡 Cera chinensis waxEricerus pela
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0169 Lou Lu漏芦 Uniflower swisscentauryRhaponticum uniflorum
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0577 Tu Niu Xi土牛膝 Common achyranthesAchyranthes aspera
H0894 Chuan Xu Duan川续断 Himalayan teaselDipsacus asperoides
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H1004 Bai Cha白茶 White teaCamellia sinensis
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0622 Xi He Liu西河柳 Chinese tamarisk twigCacumen tamaricis
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0158 Liu Ling Ju六棱菊 NALaggera alata
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum