Compound Description
| ID: C0476 | Common name: Ursolic Acid |
| IUPAC: (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid | CAS: CAS:77-52-1 |
| Chembl ID: CHEMBL169 | Pubchem ID: CID:64945 |
| Formula: C30H48O3 | TCM-ID: TCMC2216 |
| Smiles: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O | |
| Alias:
Urs-12-en-28-oic acid, 3β-hydroxy-;
(3β)-3-Hydroxyurs-12-en-28-oic acid; (+)-Ursolic acid; 3β-Hydroxyurs-12-en-28-oic acid; Bungeolic acid; Malol; Merotaine; NSC 167406; NSC 4060; Neoage UR; Prunol; Ursolic acid; Ursolisome; Urson; β-Ursolic acid |
Structure:
|
Related Targets (Total: 78)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
A | 1 Reference(s) |
| T90ZKN | Cathepsin B | CTSB |
P07858 |
A | 1 Reference(s) |
| T70OGQ | Sodium/potassium-transporting ATPase subunit alpha-1 | ATP1A1 |
P05023 |
A | 1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
A | 1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
A | 1 Reference(s) |
| T73EVE | Cyclic AMP-dependent transcription factor ATF-2 | ATF2 |
P15336 |
A | 1 Reference(s) |
| T75B9S | Cyclic AMP-responsive element-binding protein 1 | CREB1 |
P16220 |
A | 1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
A | 1 Reference(s) |
| T34FQX | Protein kinase C zeta type | PRKCZ |
Q05513 |
A | 1 Reference(s) |
| T74QOR | Tyrosine-protein kinase JAK3 | JAK3 |
P52333 |
A | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
A | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
A | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
A | 1 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
A | 1 Reference(s) |
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
A | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
A | 1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
A | 1 Reference(s) |
| T32KN9 | Alpha-amylase 1A | AMY1A |
P0DUB6 |
A | 1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
A | 3 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 2 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
A | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
B | 4 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
B | 7 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
B | 3 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
B | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 3 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
B | 1 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
B | 1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
B | 1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
B | 2 Reference(s) |
| T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
B | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 6 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
B | 4 Reference(s) |
| T39YUJ | Tyrosine-protein phosphatase non-receptor type 6 | PTPN6 |
P29350 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 5 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
B | 1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
B | 2 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
B | 1 Reference(s) |
| T95H9O | Stromelysin-2 | MMP10 |
P09238 |
B | 1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
B | 3 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
B | 2 Reference(s) |
| T38OH4 | Caspase-1 | CASP1 |
P29466 |
B | 1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
B | 2 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
B | 2 Reference(s) |
| T77FOL | Neuromodulin | GAP43 |
P17677 |
C | 1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
C | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
C | 1 Reference(s) |
| T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
C | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
C | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
C | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
C | 1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
C | 1 Reference(s) |
| T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
C | 1 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
C | 1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
C | 1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
C | 1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
C | 1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
C | 1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
C | 1 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
C | 1 Reference(s) |
| T04UTZ | G1/S-specific cyclin-E1 | CCNE1 |
P24864 |
C | 1 Reference(s) |
| T80OPZ | NADPH oxidase 4 | NOX4 |
Q9NPH5 |
C | 1 Reference(s) |
| T53ES3 | Protein S100-A1 | S100A1 |
P23297 |
C | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
C | 1 Reference(s) |
| T04A6O | UDP-glucuronosyltransferase 1A3 | UGT1A3 |
P35503 |
C | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
C | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
C | 1 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
C | 1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
C | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
C | 1 Reference(s) |
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
C | 1 Reference(s) |
| T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
C | 1 Reference(s) |
| T37WQE | Kallikrein-5 | KLK5 |
Q9Y337 |
C | 1 Reference(s) |
| T16DCZ | Twist-related protein 1 | TWIST1 |
Q15672 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 99)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0494 | Shui Yang Mei Gen | 水杨梅根 | Japanese avens root | Geum japonicum |
| H0289 | Niu Bang Zi | 牛蒡子 | Great burdock fruit | Arctium lappa |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H1109 | Bai Hua She She Cao | 白花蛇舌草 | Spreading hedyitis | Oldenlandia diffusa |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0193 | Ma Bian Cao | 马鞭草 | European verbena | Verbena officinalis |
| H1203 | Hu Ji Sheng | 槲寄生 | Colored mistletoe | Viscum coloratum |
| H0063 | Jin Ye Zi | 金叶子 | Yunnan craibiodendron | Craibiodendron yunnanese |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H1049 | Feng Xiang Zhi Chou Gao | 枫香脂稠膏 | NA | Liquidambar formosana |
| H0365 | Rou Dou Kou | 肉豆蔻 | Common nutmeg | Myristica fragrans |
| H1127 | Guang Shan Zha | 广山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0308 | Pi Ba Ren | 枇杷仁 | NA | Eriobotrya japonica |
| H0844 | Zi Cao | 紫草 | Redroot gromwell | Lithospermum erythrorhizon |
| H0693 | Xue Xie | 血蝎 | Dragon's blood | Daemonorops draco |
| H0701 | Yan Bai | 岩柏 | NA | Juniperus formosana |
| H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
| H0747 | An Xi Xiang | 安息香 | Sumatra snowbel | Styrax benzoin |
| H0493 | Shui Yang Mei | 水杨梅 | Japanese avens | Geum japonicum |
| H0300 | Nv Zhen Zi | 女贞子 | Glossy privet fruit | Ligustrum lucidum |
| H1047 | Feng Xiang Ye | 枫香叶 | NA | Liquidambar formosana |
| H0632 | Xia Ku Cao | 夏枯草 | Common selfheal | Prunella vulgaris |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H0470 | Shi Ye | 柿叶 | Persimmon leaf | Diospyros kaki |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1138 | Bai Jiang Cao | 败酱草 | All - grass of dahurian patrinia | Thlaspi arvense |
| H0422 | Shan Zha Tan | 山楂炭 | Chinese hawthorn | Crataegus pinnatifida |
| H0419 | Shan Zha | 山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0020 | Ji Yan Cao | 鸡眼草 | Striate kummerowia | Kummerowia striata |
| H0902 | Chun Pi | 椿皮 | Ailanthus bark, tree of heaven bark | Ailanthi cortex |
| H0229 | Mao Da Ding Cao | 毛大丁草 | Pilose gerbera | Gerbera piloselloides |
| H1099 | Gou Teng | 钩藤 | Sharpleaf gambirplant | Uncaria rhynchophylla |
| H1097 | Gong Ding Xiang | 公丁香 | NA | Syzygium aromaticum |
| H0854 | Zi Wei Gen Pi | 紫葳根皮 | NA | Campsis grandiflora |
| H0855 | Chuan Bei Mu | 川贝母 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H0565 | Tu Bie Chong | 土鳖虫 | Cockroach | Eupolyphaga sinensis |
| H0591 | Wei Ling Cai | 委陵菜 | Chinese cinquefoil | Potentilla chinensis |
| H0085 | Jiu Yu Rou | 酒萸肉 | Asiatic cornelian cherry | Cornus officinalis |
| H0420 | Shan Zha Chou Gao | 山楂稠膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0519 | Suo Yang | 锁阳 | Songaria cynomorium | Cynomorium songaricum |
| H0169 | Lou Lu | 漏芦 | Uniflower swisscentaury | Rhaponticum uniflorum |
| H0427 | Shan Zhu Yu | 山茱萸 | Asiatic cornelian cherry | Cornus officinalis |
| H1186 | Hong Gen Cao | 红根草 | Hispid sage | Salvia prionitis |
| H0072 | Jing Jie | 荆芥 | Fineleaf schizonepeta | Schizonepeta tenuifolia |
| H0577 | Tu Niu Xi | 土牛膝 | Common achyranthes | Achyranthes aspera |
| H0801 | Chong Bai La | 虫白蜡 | Cera chinensis wax | Ericerus pela |
| H0496 | Shui Ze Lan | 水泽兰 | NA | Lycopus lucidus |
| H1128 | Bai Jiang | 败酱 | Whiteflower patrinia | Patrinia villosa |
| H0990 | Ding Xiang | 丁香 | Clove tree | Syzygium aromaticum |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H0074 | Jing Jie Tan | 荆芥炭 | NA | Schizonepetae herba |
| H0656 | Xiao Bo Gen | 小檗根 | Barberry root | Berberis julianae |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0989 | Ding Kui Cao | 丁葵草 | Herb of twinleaf zornia | Kummerowia striata |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0177 | Lu Lu Tong | 路路通 | Beautiful sweetgum | Liquidambar formosana |
| H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
| H0638 | Xiang Bei | 象贝 | Fritillaria | Fritillaria thunbergii |
| H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
| H0216 | Man Jing Ye | 蔓荆叶 | Threeleaf chastetree leaf | Vitex trifolia |
| H0361 | Ren Zi Cao | 人字草 | Herb of twinleaf zornia | Kummerowia striata |
| H0871 | Chuan Duan | 川断 | Teasels | Dipsacus asper |
| H0320 | Qi Shu Gen | 漆树根 | true lacquertree root | Toxicodendron succedaneum |
| H0068 | Jin Ying Zi Rou | 金樱子肉 | Cherokee rose seed | Rosa laevigata |
| H0967 | Di Er Cao | 地耳草 | Japanese stJohn’swort | Hypericum japonicum |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0859 | Chuan Bei Mu Liu Jin Gao | 川贝母流浸膏 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0733 | Ye Shan Zha | 野山楂 | nippon bawthorn | Crataegus pinnatifida |
| H0073 | Jing Jie Sui | 荆芥穗 | NA | Schizonepetae spica |
| H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
| H0217 | Man Jing Zi | 蔓荆子 | Threeleaf chastetree fruit | Vitex trifolia |
| H0646 | Xiang Qing Lan | 香青兰 | Dragonhead | Dracocephalum moldavica |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0715 | Che Qian Zi | 车前子 | seed of asiatic pantain | Plantago asiatica |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H0963 | Dao Kou Cao | 倒扣草 | NA | Achyranthes aspera |
| H0226 | Man Yue Mei | 蔓越莓 | Cranberry | Vaccinium oxycoccos |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H0158 | Liu Ling Ju | 六棱菊 | NA | Laggera alata |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
| H0067 | Jin Ying Zi | 金樱子 | Cherokee rose seed | Rosa laevigata |
| H1211 | Bai Mei | 白眉 | pilose gerbera herb | Gerbera piloselloides |
| H0421 | Shan Zha Qing Gao | 山楂清膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0423 | Shan Zha Ye | 山楂叶 | NA | Crataegi folium |
| H0087 | Ju Gu Ye | 枸骨叶 | FOLIUM iLICIS cORNUTAE | Ilex cornuta |
| H0622 | Xi He Liu | 西河柳 | Chinese tamarisk twig | Cacumen tamaricis |
| H0069 | Jin Ying Zi Ti Qu Ye | 金樱子提取液 | Cherokee rose seed | Rosa laevigata |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0503 | Song Jie | 松节 | Knotty pine wood, pine nodular branch | Lignum pini nodi |
| H0894 | Chuan Xu Duan | 川续断 | Himalayan teasel | Dipsacus asperoides |
| H0453 | Shi Di | 柿蒂 | Persimmon persistent calyx | Diospyros kaki |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
Ckey description of the interaction between compound and target