Target Description

Type Detail
Target ID T74QOR
Protein Name Tyrosine-protein kinase JAK3
Uniprot ID P52333
Protein Name Alias EC 2.7.10.2;  Janus kinase 3;  JAK-3;  Leukocyte janus kinase;  L-JAK
Gene ID 3718
Gene Symbol JAK3
Gene Alias NA
TTD T23172: Successful target
Pfam PF07714 ; PF18379 ; PF18377 ; PF17887
GO
0071104:response to interleukin-9

0005768:endosome

0019221:cytokine-mediated signaling pathway

0005829:cytosol

0002250:adaptive immune response

0007167:enzyme linked receptor protein signaling pathway

0018108:peptidyl-tyrosine phosphorylation

0038110:interleukin-2-mediated signaling pathway

0045626:negative regulation of T-helper 1 cell differentiation

0050868:negative regulation of T cell activation

0045221:negative regulation of FasL production

0035723:interleukin-15-mediated signaling pathway

0004713:protein tyrosine kinase activity

0042102:positive regulation of T cell proliferation

0004715:non-membrane spanning protein tyrosine kinase activity

0006468:protein phosphorylation

0035556:intracellular signal transduction

0004714:transmembrane receptor protein tyrosine kinase activity

0032695:negative regulation of interleukin-12 production

0005524:ATP binding

0070232:regulation of T cell apoptotic process

0000165:MAPK cascade

0019903:protein phosphatase binding

0005856:cytoskeleton

0002731:negative regulation of dendritic cell cytokine production

0070670:response to interleukin-4

0038113:interleukin-9-mediated signaling pathway

0007260:tyrosine phosphorylation of STAT protein

0032693:negative regulation of interleukin-10 production

0038111:interleukin-7-mediated signaling pathway

0045087:innate immune response

0060397:growth hormone receptor signaling pathway via JAK-STAT

0043029:T cell homeostasis

0005886:plasma membrane

0070244:negative regulation of thymocyte apoptotic process

0042981:regulation of apoptotic process

0030183:B cell differentiation

0038114:interleukin-21-mediated signaling pathway

0035771:interleukin-4-mediated signaling pathway

0070672:response to interleukin-15

0030218:erythrocyte differentiation

0046425:regulation of receptor signaling pathway via JAK-STAT

0070669:response to interleukin-2

PDB 1YVJ ; 7APG ; 4V0G ; 6DUD ; 4I6Q ; 6DB3 ; 6DB4 ; 3ZEP ; 5LWN ; 4Z16 ; 4HVD ; 7C3N ; 5VO6 ; 4HVI ; 5TTU ; 4HVG ; 5W86 ; 6DA4 ; 6NY4 ; 3ZC6 ; 4RIO ; 5TTS ; 5TTV ; 3LXK ; 6GL9 ; 3LXL ; 6HZV ; 6AAK ; 5WFJ ; 4QPS ; 6GLB ; 5TOZ ; 7APF ; 3PJC ; 4HVH ; 6GLA ; 4QT1 ; 5LWM
Drugbank DB06321 ; DB04716 ; DB11817 ; DB15035 ; DB08895 ; DB12010
KEGG hsa:3718

Related Compounds  (Total: 4)

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C0476
Name: Ursolic Acid
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C0850
Name: Curcumol
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C1084
Name: cucurbitacin i
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C1172
Name: Berberine Chloride


Related Herbs  (Total: 114)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0494 Shui Yang Mei Gen水杨梅根 Japanese avens rootGeum japonicum
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1109 Bai Hua She She Cao白花蛇舌草 Spreading hedyitisOldenlandia diffusa
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0063 Jin Ye Zi金叶子 Yunnan craibiodendronCraibiodendron yunnanese
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1049 Feng Xiang Zhi Chou Gao枫香脂稠膏 NALiquidambar formosana
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0701 Yan Bai岩柏 NAJuniperus formosana
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0493 Shui Yang Mei水杨梅 Japanese avensGeum japonicum
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H1047 Feng Xiang Ye枫香叶 NALiquidambar formosana
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H1004 Bai Cha白茶 White teaCamellia sinensis
H0470 Shi Ye柿叶 Persimmon leafDiospyros kaki
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H0902 Chun Pi椿皮 Ailanthus bark, tree of heaven barkAilanthi cortex
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0854 Zi Wei Gen Pi紫葳根皮 NACampsis grandiflora
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0591 Wei Ling Cai委陵菜 Chinese cinquefoilPotentilla chinensis
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0169 Lou Lu漏芦 Uniflower swisscentauryRhaponticum uniflorum
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0577 Tu Niu Xi土牛膝 Common achyranthesAchyranthes aspera
H0801 Chong Bai La虫白蜡 Cera chinensis waxEricerus pela
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0177 Lu Lu Tong路路通 Beautiful sweetgumLiquidambar formosana
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0320 Qi Shu Gen漆树根 true lacquertree rootToxicodendron succedaneum
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0646 Xiang Qing Lan香青兰 DragonheadDracocephalum moldavica
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0715 Che Qian Zi车前子 seed of asiatic pantainPlantago asiatica
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0963 Dao Kou Cao倒扣草 NAAchyranthes aspera
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0158 Liu Ling Ju六棱菊 NALaggera alata
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H0622 Xi He Liu西河柳 Chinese tamarisk twigCacumen tamaricis
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0503 Song Jie松节 Knotty pine wood, pine nodular branchLignum pini nodi
H0894 Chuan Xu Duan川续断 Himalayan teaselDipsacus asperoides
H0453 Shi Di柿蒂 Persimmon persistent calyxDiospyros kaki
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0464 Shi Liu Zi石榴子 NAPunica granatum