HIT-result

Type	Detail
Target ID	T19BO9
Protein Name	Bone morphogenetic protein 4
Uniprot ID	P12644
Protein Name Alias	BMP-4; Bone morphogenetic protein 2B; BMP-2B
Gene ID	652
Gene Symbol	BMP4
Gene Alias	BMP2B; DVR4
TTD	T77410: Research target
Pfam	PF00019 ; PF00688
GO	2000007:negative regulation of metanephric comma-shaped body morphogenesis 0001934:positive regulation of protein phosphorylation 2000005:negative regulation of metanephric S-shaped body morphogenesis 0071773:cellular response to BMP stimulus 0010628:positive regulation of gene expression 0043401:steroid hormone mediated signaling pathway 0021904:dorsal/ventral neural tube patterning 0060976:coronary vasculature development 0007281:germ cell development 0030224:monocyte differentiation 0001958:endochondral ossification 0061047:positive regulation of branching involved in lung morphogenesis 0060433:bronchus development 0042306:regulation of protein import into nucleus 0042487:regulation of odontogenesis of dentin-containing tooth 0035993:deltoid tuberosity development 0003197:endocardial cushion development 0072125:negative regulation of glomerular mesangial cell proliferation 0001843:neural tube closure 0055020:positive regulation of cardiac muscle fiber development 0042056:chemoattractant activity 0003337:mesenchymal to epithelial transition involved in metanephros morphogenesis 0060235:lens induction in camera-type eye 0005576:extracellular region 0060272:embryonic skeletal joint morphogenesis 0045839:negative regulation of mitotic nuclear division 0060449:bud elongation involved in lung branching 0000186:activation of MAPKK activity 0060391:positive regulation of SMAD protein signal transduction 0060442:branching involved in prostate gland morphogenesis 0010942:positive regulation of cell death 0003323:type B pancreatic cell development 0003148:outflow tract septum morphogenesis 0008284:positive regulation of cell population proliferation 0048754:branching morphogenesis of an epithelial tube 0030218:erythrocyte differentiation 0072198:mesenchymal cell proliferation involved in ureter development 0001822:kidney development 1905312:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis 0003180:aortic valve morphogenesis 0045603:positive regulation of endothelial cell differentiation 0060440:trachea formation 0051150:regulation of smooth muscle cell differentiation 0007492:endoderm development 0021983:pituitary gland development 0003014:renal system process 0050679:positive regulation of epithelial cell proliferation 0060687:regulation of branching involved in prostate gland morphogenesis 0048392:intermediate mesodermal cell differentiation 0060393:regulation of pathway-restricted SMAD protein phosphorylation 0005788:endoplasmic reticulum lumen 0005125:cytokine activity 0045944:positive regulation of transcription by RNA polymerase II 0003279:cardiac septum development 0060502:epithelial cell proliferation involved in lung morphogenesis 0009948:anterior/posterior axis specification 0010159:specification of animal organ position 0008285:negative regulation of cell population proliferation 0050680:negative regulation of epithelial cell proliferation 0072192:ureter epithelial cell differentiation 0032331:negative regulation of chondrocyte differentiation 0042475:odontogenesis of dentin-containing tooth 0043065:positive regulation of apoptotic process 0070374:positive regulation of ERK1 and ERK2 cascade 0055007:cardiac muscle cell differentiation 0035990:tendon cell differentiation 0003184:pulmonary valve morphogenesis 0070700:BMP receptor binding 0072200:negative regulation of mesenchymal cell proliferation involved in ureter development 0042476:odontogenesis 0032092:positive regulation of protein binding 0010862:positive regulation of pathway-restricted SMAD protein phosphorylation 0048286:lung alveolus development 0021978:telencephalon regionalization 0060425:lung morphogenesis 0007182:common-partner SMAD protein phosphorylation 1901964:positive regulation of cell proliferation involved in outflow tract morphogenesis 0008201:heparin binding 0035116:embryonic hindlimb morphogenesis 0048745:smooth muscle tissue development 0060113:inner ear receptor cell differentiation 0039706:co-receptor binding 0072138:mesenchymal cell proliferation involved in ureteric bud development 0048661:positive regulation of smooth muscle cell proliferation 0060548:negative regulation of cell death 0010453:regulation of cell fate commitment 0090194:negative regulation of glomerulus development 0061036:positive regulation of cartilage development 0045892:negative regulation of transcription, DNA-templated 0008083:growth factor activity 0072104:glomerular capillary formation 0002244:hematopoietic progenitor cell differentiation 0043066:negative regulation of apoptotic process 0033088:negative regulation of immature T cell proliferation in thymus 0060395:SMAD protein signal transduction 0061149:BMP signaling pathway involved in ureter morphogenesis 0045606:positive regulation of epidermal cell differentiation 0010629:negative regulation of gene expression 0090184:positive regulation of kidney development 0021537:telencephalon development 0060503:bud dilation involved in lung branching 0003130:BMP signaling pathway involved in heart induction 0045666:positive regulation of neuron differentiation 0043407:negative regulation of MAP kinase activity 0045778:positive regulation of ossification 0042733:embryonic digit morphogenesis 0000122:negative regulation of transcription by RNA polymerase II 0061155:pulmonary artery endothelial tube morphogenesis 0034504:protein localization to nucleus 0010595:positive regulation of endothelial cell migration 0030225:macrophage differentiation 0045662:negative regulation of myoblast differentiation 0048663:neuron fate commitment 0045843:negative regulation of striated muscle tissue development 0002062:chondrocyte differentiation 0061151:BMP signaling pathway involved in renal system segmentation 0072193:ureter smooth muscle cell differentiation 0042326:negative regulation of phosphorylation 0060684:epithelial-mesenchymal cell signaling 0060592:mammary gland formation 0032967:positive regulation of collagen biosynthetic process 0060441:epithelial tube branching involved in lung morphogenesis 0033085:negative regulation of T cell differentiation in thymus 0009791:post-embryonic development 0072205:metanephric collecting duct development 1903800:positive regulation of production of miRNAs involved in gene silencing by miRNA 0072161:mesenchymal cell differentiation involved in kidney development 0044267:cellular protein metabolic process 0003139:secondary heart field specification 0003149:membranous septum morphogenesis 2001237:negative regulation of extrinsic apoptotic signaling pathway 2000137:negative regulation of cell proliferation involved in heart morphogenesis 0060438:trachea development 0010718:positive regulation of epithelial to mesenchymal transition 0048701:embryonic cranial skeleton morphogenesis 0002320:lymphoid progenitor cell differentiation 0005615:extracellular space 0045893:positive regulation of transcription, DNA-templated 0045786:negative regulation of cell cycle 0060363:cranial suture morphogenesis 0001938:positive regulation of endothelial cell proliferation 0061626:pharyngeal arch artery morphogenesis 0045669:positive regulation of osteoblast differentiation 0001658:branching involved in ureteric bud morphogenesis 0001649:osteoblast differentiation 0071893:BMP signaling pathway involved in nephric duct formation 0061312:BMP signaling pathway involved in heart development 0072097:negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway 0007500:mesodermal cell fate determination 0060686:negative regulation of prostatic bud formation 0002043:blood vessel endothelial cell proliferation involved in sprouting angiogenesis 0072015:glomerular visceral epithelial cell development 1902894:negative regulation of pri-miRNA transcription by RNA polymerase II 0030513:positive regulation of BMP signaling pathway 0070244:negative regulation of thymocyte apoptotic process 0001657:ureteric bud development 0030509:BMP signaling pathway 0072101:specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway 0001823:mesonephros development 0043687:post-translational protein modification 0030501:positive regulation of bone mineralization 0060197:cloacal septation 0090191:negative regulation of branching involved in ureteric bud morphogenesis
PDB	NA
Drugbank	DB01373
KEGG	hsa:652

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Name: Fraxetin

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Name: Icariin

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Name: Uridine Triphosphate

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Name: Butylated Hydroxytoluene

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0631	Xi Yang Shen	西洋参	American ginseng	Panax quinquefolium
H0085	Jiu Yu Rou	酒萸肉	Asiatic cornelian cherry	Cornus officinalis
H0752	Yin Yang Huo Gan Gao Fen	淫羊藿干膏粉	Epimedium sagittatum	Epimedium brevicornum
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0104	Bai Zhu	白术	Largehead atractylodes	Atractylodes macrocephala
H0561	Tong Ji Li	潼蒺藜	Flatstem milkvetch seed	Semen astragali complanati
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0524	Tan Xiang	檀香	Sandalwood	Santalum album
H0218	Man Jiu Jie	蔓九节	Creeping ninenode	Psychotria serpens
H0901	Chun Gen Teng	春根藤	Twig and leaf of creeping psychotria	Psychotria serpens
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0083	Jiu Jie Cha	九节茶	Glabrous sarcandra	Sarcandra glabra
H0335	Qin Pi	秦皮	bark of largeleaf chinese ash	Cortex fraxini
H0188	Lv Cao	葎草	Japanese hop	Humulus japonicus
H0924	Da Fu Pi	大腹皮	pericarp of betelnutpalm	Pericarpium arecae
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0134	Li Zhi He	荔枝核	Lychee seed	Litchi chinensis
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0169	Lou Lu	漏芦	Uniflower swisscentaury	Rhaponticum uniflorum
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0612	Cao Shan Hu Jin Gao	草珊瑚浸膏	NA	Sarcandra glabra
H0427	Shan Zhu Yu	山茱萸	Asiatic cornelian cherry	Cornus officinalis
H1236	Huang Hua	黄花	NA	Hemerocallis citrina
H0751	Yin Yang Huo	淫羊藿	NA	Epimedium brevicornum
H0401	Sha Yuan Ji Li	沙苑蒺藜	Seed of flaststem milkvetch	Semen astragali complanati
H0613	Wu Yue Ai	五月艾	Artemisia	Artemisia princeps
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0416	Shan Shen	山参	NA	Panax ginseng
H0753	Yin Yang Huo Jin Gao	淫羊藿浸膏	Epimedium sagittatum	Epimedium brevicornum
H0402	Sha Yuan Zi	沙苑子	Flatstem milkvetch seed	Semen astragali complanati
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 45)