Target Description

Type Detail
Target ID T48K08
Protein Name Procathepsin L
Uniprot ID P07711
Protein Name Alias EC 3.4.22.15;  Cathepsin L1;  Major excreted protein;  MEP
Gene ID 1514
Gene Symbol CTSL
Gene Alias CTSL1
TTD T41141: Clinical Trial target
Pfam PF08246 ; PF00112
GO
0070062:extracellular exosome

0019065:receptor-mediated endocytosis of virus by host cell

0019886:antigen processing and presentation of exogenous peptide antigen via MHC class II

0071888:macrophage apoptotic process

0016540:protein autoprocessing

0005615:extracellular space

0001968:fibronectin binding

0042393:histone binding

0039654:fusion of virus membrane with host endosome membrane

0046718:viral entry into host cell

0031638:zymogen activation

0005764:lysosome

0097655:serpin family protein binding

0048002:antigen processing and presentation of peptide antigen

0030574:collagen catabolic process

0008234:cysteine-type peptidase activity

0005576:extracellular region

0062023:collagen-containing extracellular matrix

0002250:adaptive immune response

0005794:Golgi apparatus

0005886:plasma membrane

0071682:endocytic vesicle lumen

0006508:proteolysis

0004197:cysteine-type endopeptidase activity

0043394:proteoglycan binding

0022617:extracellular matrix disassembly

0034230:enkephalin processing

0043202:lysosomal lumen

0043373:CD4-positive, alpha-beta T cell lineage commitment

0005518:collagen binding

0051603:proteolysis involved in cellular protein catabolic process

0005771:multivesicular body

0005634:nucleus

0019064:fusion of virus membrane with host plasma membrane

0006955:immune response

0002224:toll-like receptor signaling pathway

0019882:antigen processing and presentation

0060309:elastin catabolic process

0042583:chromaffin granule

0045616:regulation of keratinocyte differentiation

0043231:intracellular membrane-bounded organelle

0097067:cellular response to thyroid hormone stimulus

0016324:apical plasma membrane

0036021:endolysosome lumen

PDB 2XU5 ; 2XU3 ; 4AXM ; 2NQD ; 5MAE ; 2YJ2 ; 2YJ9 ; 3HHA ; 6EZP ; 3OF9 ; 1CS8 ; 5F02 ; 1MHW ; 3H8B ; 3IV2 ; 3HWN ; 3H8C ; 5MQY ; 1CJL ; 3OF8 ; 3BC3 ; 5MAJ ; 6EZX ; 2YJ8 ; 2YJC ; 6JD8 ; 2VHS ; 2XU4 ; 6JD0 ; 4AXL ; 6F06 ; 1ICF ; 2YJB ; 2XU1 ; 3K24 ; 3KSE ; 5I4H ; 3H89
Drugbank DB12010 ; DB14962 ; DB07477 ; DB03661
KEGG hsa:1514

Related Compounds  (Total: 2)

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C0653
Name: 20-Hydroxyecdysone
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C0846
Name: Acetaldehyde


Related Herbs  (Total: 31)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0077 Jiu EthanolVinum
H0793 Zhao Shan Bai照山白 Manchurian rhododendronRhododendron micranthum
H0260 Mo Xiang没香 MyrrhCommiphora myrrha
H0051 Jin Guo Lan金果榄 Hairystalk tinosporaTinospora capillipes
H0261 Mo Yao没药 MyrrhCommiphora myrrha
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0696 Ya Jiao Ai鸭脚艾 Ghostplant wormwoodArtemisia lactiflora
H0254 Mian Ma Guan Zhong绵马贯众 Male fern rhizomeRhizoma dryopteris crassirhizomae
H0336 Qin Jiao秦艽 large-leaved gentianGentiana macrophylla
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0337 Qin Jiao Hua秦艽花 large-leaved gentian flowerGentiana straminea
H0297 Niu Xi牛膝 Twotooth achyranthesAchyranthes bidentata
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0938 Da Suan大蒜 GarlicAllium sativum
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0782 Zao Xiu蚤休 NAParis polyphylla
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0169 Lou Lu漏芦 Uniflower swisscentauryRhaponticum uniflorum
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0322 Qi Ye Yi Zhi Hua七叶一枝花 rhizome of verticillate parisParis polyphylla
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0820 Chong Lou重楼 Paris rootRhizoma paridis
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0476 Can E蚕蛾 SilkwormBombyx mori
H0296 Niu Teng牛藤 twotooth achyranthes rootAchyranthes bidentata
H0498 Si Ji Cai四季菜 Ghostplant wormwoodArtemisia lactiflora